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Values and ethics: a collection of curricular reforms for a new generation of physicians. Twenty-six variables of 37 were efficiently selected according to their ability to summarize major biomechanical constraints in a working population, with an approach combining statistical analyses and existing knowledge. The mechanism of regulation remains to be determined but may be transcriptional. This may explain, in part, unresponsiveness of glucagon to hypoglycemia often observed in insulin-dependent diabetes mellitus (IDDM) with intensive insulin therapy.

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The DnaK chaperone of Escherichia coli assists protein folding by an ATP-dependent interaction with short peptide stretches within substrate polypeptides. As 1,25 dihydroxy-vitamin D synthesis is substrate-dependent in end-stage renal disease, this could be a contributing factor to low 1,25 dihydroxy-vitamin D levels in patients undergoing conventional hemodialysis. Bilateral partial rupture of triceps tendon: case report and quantitative assessment of recovery.

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We present a case of sudden death due to spontaneous acute coronary artery dissection. The heavy- and light-chain variable-region genes were connected by a 45-base linker DNA to allow folding of the fusion protein into a functional tertiary structure.

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To investigate the hypotensive and angiotensin-converting enzyme (ACE) inhibitory activities of a partially purified fraction (FA-I) of the leaves of Gynura procumbens and to qualitatively analyse the putative compounds present in the fraction. PCNA2 can form a trimeric structure by itself, and it also forms heterotrimeric structures with PCNA1 and PCNA3. Comparative investigations on cytochemical and cytohormonal exponents of estrogens- progesteron activity in vaginal epithelium in women with complicated pregnancy.

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Nucleotide sequence and intergeminiviral homologies of the DNA-A of papaya leaf curl geminivirus from India. Application of fluidized bed combustion to industrial waste treatment.

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Paroxysmal cervicobrachial cough-induced pain in a patient with syringomyelia extending into spinal cord posterior gray horns. Fortunately, with intensive medical surveillance and appropriate interventions, most women with types 1 and 2 diabetes mellitus can be offered an optimistic prognosis for child bearing.

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Age of 75 years or older was associated with increase in cupping at a given level of IOP, but the age association was attenuated when including refraction in multivariable models. The quality of life was evaluated with QUALIN questionnaire, specifically designed for infants.

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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. In C1 and C3, where basal NPY mRNA expression was close to or below our detection threshold, the hybridization signal was also significantly increased by 2DG. Administrators believe their nursing homes need to improve in all of these areas. This is the first time that the first order term in the semiclassical initial value representation series has been converged for systems with the order of 50 degrees of freedom. The incidence of AIDS-defining illnesses in 4883 patients with human immunodeficiency virus infection.

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The research methods used in the trial, as well as the results, will be of interest to practising nurses. Ovalbumin variants were engineered using chemical methylation or succinylation to obtain a range of protein net charge from -1 to -26. The infant was successfully treated with ceftriaxone over a 14-day period. The power of confession: the role of the criminal law and courtpractices in the production of knowledge concerning sexuality between women: Finland, in the 1950s. Delayed maculopapular, urticarial rash due to infliximab in two children with systemic onset juvenile idiopathic arthritis.

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A logit model for each sex, the vaccination probabilities, contrasts related with a reference category and the odds ratios (OR) were estimated. Liver glycogen storage diseases are metabolic disorders which result in abnormal storage amounts and/or forms of glycogen, and often (but not always) have hepatomegaly and hypoglycaemia as presenting features. Histological and histochemical studies of the stickleback Gasterosteus aculeatus L. In this chapter some of those practical applications are detailed, combined with a discussion of the implications of environmental sound research for auditory perception in general, and finally some outstanding issues and possible directions for future research are outlined.

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Epidermal enzymes: their role in homeostasis and their relationships with dermatoses. Our results indicate that exposure to PD fluids during dialysis triggers a shock response in peritoneal cells, which is manifested by significantly increased HSP-72 expression at both protein and mRNA levels.

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Pomegranate extract improves a depressive state and bone properties in menopausal syndrome model ovariectomized mice. All subjects were examined by a battery of neuropsychological tests during admission and 3 months after stroke. Echocardiography may prove most useful in a small group of patients who have a low risk of stroke according to clinical factors. Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. CYA was administered orally for 4 days prior to surgery in two doses (10 or 20 mg/kg) while controls received only the control vehicle.

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Coreceptor usage of two primary, blood-derived SIVsm isolates, SIVsmSL92b and SIVsmFNS from naturally infected sooty mangabeys, was determined. This diagnosis should be considered when child presents with upper airway obstruction emergency after ruling out other important causes of stridor and laryngoscopic examination is warranted in such cases for diagnosis.

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Furthermore, the efflux rate of oligomer initially introduced within liposomes is 2-fold lower than that observed in cells which have been incubated with free oligonucleotides. Neuroendocrine carcinoma of the breast: a case report of pure type. The aim of this investigation was to compare magnetic resonance imaging and radiography in detecting subcapital growth plate changes due to avascular necrosis after treatment for congenital dislocation of the hip. To assess cardiovascular safety profile of high dose Venlafaxine XL in patients with major depression.

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These changes were most prominent in putamen, internal capsule, thalamus and dentate nucleus. In addition, the effect of the loading concentration of analytes on the dynamic binding capacity, namely adsorption isotherm, was also investigated.

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Subjects performed forced-choice, identification tests during which allowed response directions were indicated visually. Depression in later life is often thought to differ from that at other times of adulthood. Choledocholithotomy and papillosphincterotomy in surgery of the bile ducts

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The disposition of both enantiomers appeared dose-dependent, since the AUC increased disproportionately faster than the dose. Free D-Ala-D-Ala residues at the end of muropeptides in the pre-existing cell wall generated by decreased cross-linkage seems to account for increased vancomycin binding.

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1-hour blood-xylose levels were low in 6 patients found to harbour rotavirus in the small intestinal aspirate. Review: regular inhaled short acting beta2 agonists improve lung function in stable chronic obstructive pulmonary disease.

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The effects of glucose deprivation on cerebral blood flow (CBF) have been extensively investigated during insulin-induced hypoglycemia in laboratory animals. The hypothesized processes were estimated with LISREL VIII using data from a large cross-sectional survey with a sample of 679 adults aged 65 and older who were representative of older adults living in the Detroit area. Initial findings of the Italian Randomized Tamoxifen Prevention Trial found no reduction in risk of breast cancer with tamoxifen use, whereas the National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial showed that tamoxifen treatment reduces risk of estrogen receptor-positive breast cancer. The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis. However, the actual figure of merit is very sensitive to the details of the dynamics, with decoupling performance which may deteriorate for non-Gaussian noise and/or high frequency working points.

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An atom counting strategy towards analyzing the biological activity of sex hormones. Part IV: survival of familial breast cancer in Bulgarian patients. Adrenomedullin can protect against pulmonary vascular remodeling induced by hypoxia. Decreased skeletal muscle oxygen consumption with 4 Hz exercise in early SIRS may be related to depletion of physiologic reserves, especially microcirculatory reserves, as suggested by decreased myoglobin saturation and decreased energy charge. Measuring these leaf movements provides a simple and reliable assay of the plant circadian clock and, unlike systems based on the firefly luciferase reporter gene, requires no prior genetic manipulation of the plant.

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Shoot apical meristems (SAMs) of seed plants are small groups of pluripotent cells responsible for making leaves, stems and flowers. The indentation stiffness increased or remained constant when the site of indentation approached an integrated interface in which the distal tissue was relatively stiff or similar in stiffness to the tissue being tested. A population-based genetic survey was performed on 17 BBS families from the island portion of the province of Newfoundland, a comparatively isolated region of Canada. Pulse rate increased significantly during anesthesia and surgery in the GOE group.

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As many phenotypes studied in animals are quantitative, we focus on mapping, fine mapping, and cloning of quantitative trait loci. Immunomodulation of chickens with the nonionic block polymer T150R1. Prostaglandin E2 (PGE2), a highly suppressive monokine that decreases alloreactivity, did not seem to be involved in the suppression caused by the TBH M phi/GM-CSF interaction.

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The advancing symptoms of CSM were apparently halted by the surgery in this case, until complication from a fall resulted in quadriplegia. Although exogenous supplementation of antioxidants prevents UVR-induced photooxidative damage, their effects on components of cell signalling pathways leading to gene expression has not been clearly established. The integration of the physical mapping data with previous genetic mapping data and the use of STSs and non-chimeric YAC clones reported here should facilitate the construction of a transcript map of this region and the positional cloning of disease genes in this portion of Xp22.1. This new cross-link exhibits a UV absorbance maximum at 305 nm and a molecular mass of 451 Da.

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The observations extend and complement previous studies that have implicated heat-induced chromatin damage acting in cis as a cause for the observed inhibition of DNA synthesis in cells exposed to hyperthermia. Morphology of pig uterine subepithelial capillaries after topical and systemic oestrogen treatment.

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To demonstrate the general applicability of this approach to drug discovery, we generated targeted promoter insertion cell lines for two key drug target classes -- the G protein-coupled receptor melanocortin-receptor 4 and the nuclear receptor peroxisome proliferator-activated receptor-gamma. Muscle crush injury is often complicated by hemodynamic shock, electrolyte disorders, and myoglobinuric renal failure. Surprisingly, in the water-finding test, the nociceptin receptor-knockout mice showed an enhanced retention of spatial attention (latent learning) compared to wild-type mice. Adult skin consists of epidermis, dermis and appendages such as hairs and glands which are linked to the epidermis but project deep into the dermal layer.

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Furthermore, these two classes of IL-12 inhibitors synergistically decreased hulL-12-stimulated proliferation and IFN-gamma production. Applications of gene therapy and adult stem cells in bone bioengineering.

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Following infection of Spodoptera frugiperda cells, the recombinant N-glycosylated protein is secreted into the cell culture medium from which it can be purified to homogeneity as a fully enzymatically active enzyme. Multifactorial nature of hepatocellular carcinoma drug resistance: could plant polyphenols be helpful?

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(A) Three endometrioma cell lines from patients were treated with 25 or 50 nmol/L gossypol for up to 12 days. And it had negative reaction to monocolone antibodies to VIII factor. ZAP-70 expression remains stable in chronic lymphocytic leukaemia. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein.

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Models representing type I and type II human endometrial cancers: Ishikawa H and Hec50co cells. The cultured bladder cancer cell line KU-1 was used to study the molecular mechanisms by which EGF affects urothelial tumor growth and invasion activity.

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The blood levels of TNF alpha and IL-1 alpha did not rise at this time, suggesting that the most important cytokine promoting inflammation one week after LPS stimulation was neither TNF alpha nor IL-1 alpha. In clinical practice, there is an unavoidable lag between the hypoxic-ischemic (HI) insult and the opportunity to initiate cooling. It was also found that women using family practitioners were less likely to delay than women using other types of physicians. Combined CEE plus MPA for more than 5 years are no more risk related to breast cancer and cardiovascular events versus shorter treatments. Alcohol attenuated the amplitude of N100 to both Finnish and English words, this attenuation being significantly stronger for English than for Finnish words.

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A young patient receiving ovulation induction therapy was admitted to our department with sudden chest pain and dyspnea. The growth-inhibitory effects of pRB are exerted, at least in part, through the E2F family of transcription factors. In vivo antegrade fenestration of aortic endografts is technically feasible. Angiography is useful in following selected patients with chemodectoma of the head and neck treated by radiotherapy.

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The protein cystic fibrosis transmembrane conductance regulator (CFTR), the gene product defective in cystic fibrosis, functions as a cAMP-activated chloride channel in the plasma membrane. This prosthesis engages teeth on both dental arches for retention and stability. Phospholipase A2 doses ranging from 100 to 400 U were applied on the mechanically sensitive segments of the dorsal root ganglia, and responses to varying doses were evaluated in relation to elapsed time. The distance from implant shoulder and bone crest was measured for each implant at four sites (mesial, buccal, distal, and palatal/lingual). This is the first observation of seasonal changes in glomerular filtration rate that are unrelated to dietary and water stresses.

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Ossifying renal tumor of infancy presenting as a palpable abdominal mass. The presence of anti-CCP Ab is the most accurate biomarker for RA in both selected and unselected cohorts, while the COMP assay is not very useful in RA diagnosis. A 45-year-old house-wife, who had undergone surgical treatment for lung adenocarcinoma 2 years previously, presented with a left renal mass detected by follow-up CT. In addition, tyrosine phosphorylation of Jak2 was undetected in CML-CP platelets before TPO treatment.

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Compatible biomass estimation models of natural forests in Changbai Mountains based on forest inventory We show that the altered morphology of Atofp1-1D mutant is caused by reduced cell length resulting from reduced cell elongation, and demonstrate that a mutant harboring a transposon insertion that disrupts the OVATE domain of AtOFP1 is indistinguishable from wild-type plants. ATPase) or for physiological and biochemical properties (such as effects on uterine tone or the protection of mitochondrial membranes). Presentations included food science behind fatty acid technology, the health science of dietary fatty acids, alternatives to trans fatty acids, and the use of alternatives in food manufacturing and food service.

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The role of structural changes in the matrix-spacer-ligand system for different types of adsorbents is studied as well as a dependence of sorption on pH and salt environment. Phenanthroline treatment of growing cultures of the free-living nematode Panagrellus silusiae was used to lower the degree of hydroxylation of nascent collagen chains at the polysomal level.

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Objective criteria have been identified that are valid for distinguishing between these two clinical problems. The goals of the present study were to characterize pre- and postsynaptic dopamine function in recently detoxified cocaine-dependent subjects. The bacterial pathogen Listeria monocytogenes propels itself in the cytoplasm of the infected cells by forming a filamentous comet tail assembled by the polymerization of the cytoskeletal protein actin. The number of beds was stepwise reduced from 133 to 44 and the average length of stay declined from 48 to 16 days.

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Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes. This is an observational study based on the biochemical analysis of proteoglycans. Schools were randomly selected from each education sector in each state. Dilated cardiomyopathy in the practice of a therapist and cardiologist (lecture)

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Indicators of the kallikrein-kinin system in children with active phase of rheumatism Overall, use of the LQ formalism to predict dose-time relationships is a notably robust procedure, depending less than previously thought on knowledge of detailed biophysical mechanisms, since various conceptually different biophysical models lead, in a reasonable approximation, to the LQ relationship including the standard form of the generalized time factor, G. CD4-independent infection of HIV and SIV: implications for envelope conformation and cell tropism in vivo. One is the high output state that results from chronic tissue hypoxia and from hypoxia-induced compensatory reactions.

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According to gel chromatographic, two-hybrid, and chemical cross-linking analyses, Sys3p forms dimers and larger protein complexes. Evidence is provided that sepsis-induced myocardial dysfunction produces indications (signs) of early stages of heart failure.