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In patients with low-grade, completely resected sarcoma, there is a significant survival benefit with treatment in a high-volume tertiary center of excellence. The cells were rendered apoptotic or necrotic by incubation with etoposide or by heat shocking, respectively. In utero stem cell transplantation and gene therapy: second international meeting, Nottingham, UK, 1-2 September 1997. Anderson et al criteria were used to assess functional and radiological outcome.

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Strength prediction of the distal radius by bone densitometry--evaluation using biomechanical tests. Conditions for maximal synthesis of cyclic AMP by mouse macrophages in response to beta-adrenergic stimulation. Several aspects of the medicosocial problems in hiring of workers The absorption of troglitazone is enhanced significantly by food with little effect on the main metabolic pathway.

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Effect of chloromycetin on the hemopoietic system in typhoid fever and paratyphoid fevers A and B In conclusion, a decrease in peripheral platelet count may be a sign of an increase in the degree of fibrosis during the course of chronic viral hepatitis B and C and factors other than hypersplenism may play a role in this decrease in the peripheral platelet count.

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Tropomyosin, a relatively late marker, is first expressed at 4 dpf. Thermodilution cardiac output measurements via a pulmonary artery catheter should not be done during the inflation cycle of lower limb SCDs because they produce a falsely low cardiac output. Alternatively, the same heavy and light chains were linked together, using PCR, with an in-frame sequence coding for a furin cleavage site.

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Histologically, the tumors were diagnosed as cavernous lymphangiomas. The enzyme preferentially cleaved X-Leu, X-Phe, X-Val, and X-His bonds. Paclitaxel (PAC) is one of the major anti-cancer drugs, effective in different tumors. This study compared patterns of feeding in infants with unrepaired cleft lip and palate with healthy noncleft infants of a similar age.

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Hyperpolarizing responses generated by focal ACh application near the somata of CA1 pyramidal neurons were blocked by atropine or the M1-like mAChR antagonist pirenzepine, but not by the M2-like mAChR antagonist methoctramine. A SIMPLE METHOD FOR THE PREPARATION OF MANOMETRIC FLUID FOR THE USE WITH THE WARBURG MANOMETER When BSO was given concurrently with NAC in normal or hyperoxic conditions, these effects were not observed, and oxidant stress was evident. A total of 632 unrelated Japanese subjects were studied: 342 type 2 diabetic patients (among them, 158 patients complicated with hypertension), 156 hypertensive patients without diabetes mellitus and 134 control subjects. Evidence is presented that Hairy-mediated repression depends on the Groucho interaction sequence (WRPW) but not the weak dCtBP motif (PLSLV) present in the native protein.

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The number of N-glycans (n) is a distinct feature of each glycoprotein sequence and cooperates with the physical properties of the Golgi N-glycan-branching pathway to regulate surface glycoprotein levels. The role of gestagens in prevention and therapy of endometrial hyperplasia

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Most programs have in place the basic elements conducive to resident research. Reduced raft-association of NF155 in active MS-lesions is accompanied by the disruption of the paranodal junction. These antigens co-partitioned with the nuclear lamina during in situ isolation of nuclear matrices from lamin A/C-positive and -negative mammalian cells. Therefore, we propose that cell-cell interaction leads to an efficient mode of stimulation, which may be mediated by or initiated by surface-associated proteases of adherent cells. Application of hepatic tolerance tests to the functional reserve assessment in rat models of fatty liver.

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Extracorporeal life support (ECLS) has been used for cardiopulmonary failure in our institution since 1988, and we reviewed our experience with its use in the management of massive pulmonary emboli. The use of locally delivered doxycycline may constitute an important adjunct for the treatment of severe periodontal disease in smokers. According to its effect on IL-5 and IFN-gamma mRNA expression, UR-1505 specifically inhibited NF-AT DNA binding without effect on nuclear factor-kappaB and activator protein-1 activities.

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The expression, regulation and activity of GLUTs play an essential role in neuronal homeostasis, since glucose represents the primary energy source for the brain. The clinical relevance of posterior laryngeal clefts (PLCs) of type 1 has only recently been highlighted in the medical literature. Interestingly, knockdown of either MPHOSPH1 or PRC1 expression with specific small interfering RNAs caused a significant increase of multinuclear cells and subsequent cell death of bladder cancer cells. Baseline data were compared with 6-month follow-up data within and between the groups. Thus these effects on gastric motility are not directly attributable to LPS nor are they due to direct effects on the gastric smooth muscle.

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Serum albumin levels remained very low and severe lymphedema occurred. The patients who relapsed within six months after discharge exhibited significantly lower growth hormone (GH) responses to GHRH at the time of discharge than those who did not relapse. Cows diagnosed pregnant at a first pregnancy examination 41 days or less after insemination were significantly less likely to subsequently have a calf than were cows diagnosed later. Glucose and visceral and subcutaneous fat presented a significant reduction after treatment in patients with NAFLD.

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In this study it is shown that stable transfection of A1 into an interleukin-3 (IL-3)-dependent myeloid precursor cell line, 32D c13, leads to a retardation of IL-3 withdrawal-induced cell death similar to that observed with transfection of bcl-2. As a result, the assay had a detection range of 5 x 10(3) to 5 x 10(8) genome equivalents (GE)/ml and good quantitative accuracy on a logarithmic scale.

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The threshold values for burst load and cyclic load prescribed by the FDA are achieved or bettered. When cultures of tsCl.B59 cells are transferred to 39 degrees C, incorporation of 3H-thymidine decreases markedly. All enzyme activities were higher in infiltrating ductal carcinomas than in fibroadenomas. The models could be sterilized and taken to the operating room for orientation during the corrective surgical procedure. Pharmacologically improving cardiac energy metabolism with drugs such as trimetazidine could be a new promising approach to the treatment of cardiovascular diseases.

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The operation has five steps: (1) midline vaginal incision and mucosal dissection, (2) Obturator foramen identification, design and performance of 2 superior mini incisions in both the genitofemoral folds, and another two 3 cm below and 1-2 cm lateral to them, (3) Needle introduction and passage through the upper portion of the obturator foramen, parallel to the ischiopubic ramus, and once past needle charging with the arm of the implant, (4) Needle introduction and passage from the inferior incisions vertically through the inferior portion of the obturator foramen, directing the needle with bimanual control to the theoretical localization of the uterine.cervix, with connection and charging of the inferior arm of the mesh. We have examined the binding specificity of Syk-derived SH2 domains in vitro and found that the tandem SH2 domains have two major ligands in activated Ramos B cells as well as in activated Jurkat T cells. Gentamicin pharmacokinetics in term newborn infants receiving high-frequency oscillatory ventilation or conventional mechanical ventilation: a case-controlled study.

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The objective of this study was to evaluate the efficacy, tolerability, and safety of mibefradil, a new selective T-type calcium channel blocker, in patients with chronic stable angina pectoris receiving concomitant beta-blocker therapy. Bcl-2 overexpression also inhibited GC-induced apoptotic events, including caspase activation and mitochondrial dysfunction. This paper concentrates on focal nodular hyperplasia, with two cases added to the four previously described cases.

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Professional antigen-presenting cells are critical components of both the innate and adaptive immune responses. A novel method for analyzing oligonucleotides of the same length, but bearing a single base substitution, is reported, based on free zone capillary electrophoresis (CZE) under rather acidic pH values. The stress-induced increase in hypothalamic dopamine was prevented by CPZ and, partially, by PHB. However, some complications were encountered, such as the turning over of the valve in the subcutaneous pocket and the twisting of the shunt tube.

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In this study, we investigated endocrine factors and behaviour in free-living Common hamsters (Cricetus cricetus) during reproductive and non-reproductive periods of the annual cycle. Potentiometric electrodes for determining choline, butyrylcholine and cholinesterase inhibitors Distribution of linear antigenic epitopes on GP120 encoded in sibling clones of novel New York HIV-1 subtype B isolates. The objective of this review is to discuss the MRI staging of the uterine cervical carcinoma, to propose a comprehensive, clinically relevant MRI examination for the assessment of uterine cervical carcinoma, and to present the correlation between MRI and pathologic imaging in comparison to the FIGO staging system. These findings suggest that somatic cell mutations in the cAMP-dependent signal transduction pathway occurring during myocardial development may be responsible for some forms of idiopathic ventricular tachycardia.

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Ito is of larger amplitude in human atrial than in ventricular myocytes. STUDIES ON IMMUNOBIOCHEMICAL SERA OF WHITE RATS WITH EXPERIMENTAL TOXOPLASMA GONDII INFECTION As a result of the success of our program, we believe that physician assistants can have an important role in radiology practice. Injuries of the upper extremity were dealt with in Part I in a previous article. Information about disability pensions was obtained from Statistics Denmark.

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The ratio IL-6:TNF-alpha, determined from IL-6- and TNF-alpha values in samples of NPS, was related to the severity of the disease. The receptors for TR1 were detected on a monocytic cell line (THP-1) and in human fibroblasts.

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The NMR proton assignments of JMV635 were achieved, and the conformations of JMV635 in aqueous solution and in trifluoroethanol at 297 K were determined using two-dimensional COSY, HOHAHA, NOESY and ROESY experiments. Brains from 17 histopathologically confirmed cases of scrapie, five of which had congophilic vascular amyloid, were stained immunohistochemically for prion protein (PrP) using a polyclonal antibody.

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The results also suggest a possibility that SP and an excitotoxin, glutamate, in the dorsal part of the spinal cord greatly contribute to the pain transmission induced by noxious heat stimulation. In situ hybridization with sense and antisense riboprobes showed that both strands are distributed throughout the embryo. In addition to these exogenous agents there are also metabolic abnormalities that can contribute, caused by genetic or epigenetic influence.

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Modifications of air composition have a proven harmful effect on health and provoke predominantly respiratory symptoms. We found that lesions involving sensorimotor areas in dorsolateral cortex affect RT for responding to visuospatial stimuli without affecting other measures of response speed or producing signs of attentional or sensory impairment. Experience accumulated with 17 pediatric patients with insulin-dependent diabetes mellitus treated with an insulin pump is reported.

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Establishment of the Australasian paediatric Charcot-Marie-Tooth disease registry. A curvilinear increase was modeled for all species, and the rate of increase correlated inversely with maximum life-span. However, areal BMD (BMDareal) is dependent on bone size and this can lead to erroneous interpretations of BMD values. After 26 months, the function of the elbow was satisfactory, and the range of motion of the wrist was from 50 degrees of flexion to 40 degrees of extension.

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Safety of inferior vena cava filters as primary treatment for proximal deep vein thrombosis. Heart rate, oxygen consumption, and peripheral arterial blood pressure were measured at regular intervals.

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Dermabacter species are commonly isolated from the skin and other body sites but rarely show pathogenicity in humans. High fear but not low fear subjects showed potentiated short-latency cardiac acceleration and blink magnitude, and reduced blink latency, during aversive compared to neutral slides. High-spatial-resolution PET appears promising for a more accurate detection of neurobiologic modifications and also for the exploration of subtle modifications in small and complex brain structures largely affected by the partial-volume effect.

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The influence of specific amino acid substitutions on the activity of the M2 protein in influenza A virus-infected cells is assessed in this report by their effects upon haemagglutinin (HA) stability and virus growth. PAMI (Primary Angioplasty in Myocardial Infarction) Stent Pilot Trial. In mice inoculated intravenously with vaccinia, a significant decrease in the number of specific tail lesions was observed if the animals were exposed to microwave hyperthermia within the first three days after infection, while irradiation prior to infection or delayed until several days after infection did not exhibit an appreciable effect. Antitumor effect of combined use of purified human natural tumor necrosis factor (N-TNF) and cis-diamminedichoroplatinum (II) (cisplatin) on the implanted bladder carcinoma (MBT-2) in mice Statistical analysis was done with analysis of variance, Spearman rank correlation, and linear regression.

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Cytofluorometry of lymphocytes infected with Epstein-Barr virus: effect of phosphonoacetic acid on nucleic acid. nov.), primarily composed of magnesian calcite ((Ca,Mg)CO3) as precursors. A study of three hospitals reveals common areas where nurse managers can change the use of physical restraints. We have identified a mutation in nanos1 using a reverse genetics method and show that young female nanos mutants contain oocytes, but fail to maintain oocyte production.

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Whether they have the same significance in these patients as in the general population is not known. Use of bioelectrical impedance analysis in the evaluation, treatment, and prevention of overweight and obesity.

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Postoperatively, she reported anterior knee pain and a revision of the joint with lateral release was carried out. Further studies are needed to clarify the precise role of azithromycin in the treatment of CF lung disease. Diagnosis is based in particular on the clinical presentation and history of exposure, and, as a rule, is confirmed by serological methods. During lactation the suckling stimulus increases the activity of two populations of neuropeptide Y (NPY) neurons in the hypothalamus, the caudal portion of the arcuate nucleus (ARH) and the dorsomedial hypothalamus (DMH), and suppresses the activity of TIDA neurons in the ARH.

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Evaluation of the effects and mechanisms of action of mercuric chloride on striatal dopamine release by using in vivo microdialysis in freely moving rats. An 8-year-old boy presented with bilateral uveitis 24 months after a bilateral lung transplant. The training consisted of four procedures (visual-spatial scanning, reading and copying training, copying of line drawings on a dot matrix, and figure description) which lasted 40 sessions. The role of viruses as primary invaders of the intestinal epithelium is stressed.

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Analysis of the reaction mechanisms of cysteine-specific ADP-ribosyltransferases revealed that free ADP-ribose combined nonenzymatically with cysteine. Questions for planning and carrying out individual care of hospitalized children Exoglycosidases modify carbohydrate epitopes on glycoproteins and glycolipids.