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Pretreatment with either Amlodipine or manidipine decreased the overexpression of VCAM-1, ICAM-1, and MCP-1. In the present manuscript the authors provide an overview of the evidence supporting the use of triple combination therapy with different classes of antihypertensive drugs, with a particular focus on those based on olmesartan medoxomil, a thiazide diuretic (hydrochlorothiazide) and a calcium channel blocker (Amlodipine besylate).

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Amlodipine is used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily. Amlodipine is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.

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The basaloid cells showed scant-to-absent cytoplasm, round-to-oval to tear-shaped nuclei, rare longitudinal nuclear grooves, single or multiple nucleoli, and smooth-to-clefted nuclear contours. The result showed that the level of membrane cholesterol in 3T3-L1 cells increases during adipose differentiation. Demographic factors affecting knowledge and knowledge of Down syndrome and newborn screening test uptake.

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Disease Reporting in Alberta : Public Relations Committe, Alberta Veterinary Medical Association. Retrospective survey of the 5600 abortion requests to the Canton Health Authority for resident women between 1990 and 1993.

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When needed, soft tissue coverage and patellar tendon augmentation would better be performed with gastrocnemius plasty. Curiously, the double mutant did not exhibit any synergistic effect in regard to fidelity of DNA synthesis as might be expected since both the single mutations (Y183F, M184V) exhibited enhanced fidelity compared to the wild-type enzyme. Under the present conditions, administration of erythromycin and neostigmine as prokinetic agents failed to alter the kinetics of an ingested dose of sustained-release acetaminophen. We present a case of hemoglobin Bassett, a possible cause of low pulse oximeter and co-oximeter readings in a 63-year-old woman. In uraemic undialysed and dialysed patients, we observed an increase in K/Cl co-transport activity and in shrinkage-induced amiloride-sensitive (HMA-sensitive) Na efflux (Na/H exchange) and a decrease in Na/K pump and Na/K/Cl co-transport activity, while Na/Li exchange was increased only in dialysed patients.

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The URA3 reporter allows self-activating sequences to be removed from the library through counter-selection. Cytotoxicity testing of poly(anhydride-co-imides) for orthopedic applications. First, we examined the effects of the mutation on haploid yeast cells.

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We show herein that when evaluated in an assay (AL cell assay), in which both intragenic and multilocus mutations are detectable, that arsenite is in fact a strong dose-dependent mutagen and that it induces mostly large deletion mutations. The eight-step synthesis described in this protocol can be completed within 4-5 weeks.

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This was more pronounced in longer-lasting urticaria lesions of acute, chronic recurrent and delayed pressure urticaria, with HLA-DR and, to a lesser degree, HLA-DP and HLA-DQ being noted on cell infiltrates, on vascular endothelia and around nerves and sweat glands. Pre-interventional intravascular ultrasound demonstrated an ultrasound attenuated coronary plaque, as a long eccentric bulky plaque with a marked decrease of the back echo without calcification. Inhibition of Rho kinase (fasudil, Y27632 or H-1152) did not affect constriction of isolated mouse tail arteries to the alpha2-AR agonist UK 14 304 at 37 degrees C but dramatically reduced the augmented responses to the agonist at 28 degrees C. Eight type 1 diabetes patients (two with autonomic neuropathy) and nine controls were studied during euglycaemia. To obtain a high level of gene expression, we tested whether a baculovirus-derived enhancer, hr3, and a trans-regulator, IE1, are capable of stimulating the transcriptional activity of the ser1 promoter, using a transient gene expression system.

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Management of recurrent anastomotic stricture and iatrogenic stenosis by circular stapler. CNS perivascular macrophages in both MA and motor neuron disease were found to closely resemble free macrophages elsewhere in the body except that they often contained unusually large primary lysosomes.

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A number of antibiotics active against gram-positive bacteria are relatively ineffective against gram-negative bacteria presumably because of the implied barrier function of the outer membrane. In most cases infection with hepatitis C results in chronic infection as a consequence of viral subversion and failed anti-viral immune responses. Local administration of CP 93,129 (10 microM) to the dorsal surface of the medulla had no significant inhibitory effect on the release. Combined operations as a method for increasing the capacity of a surgical clinic

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COX-2 expression has been shown to increase in many cancers and cancer cell lines, including human prostate adenocarcinoma. In the AKR strain of mice a high incidence of spontaneous lymphoid leukemia develops before 12 months of age. DNA sequencing with pulsed-field capillary electrophoresis in poly(ethylene oxide) matrix. Results obtained by numerical simulation are in good agreement with experimental values and that allows us to validate the computer model. The results from this study using inexperienced listeners were not basically different from those reported in the literature based on experienced listeners, suggesting a possible difference does exist between inferences drawn from fTMRI data and human psychophysical results.

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Here we use a genetic approach to determine the direct role of JAK2 in SCF-mediated growth and differentiation of primary hematopoietic cells. Measurements of gaseous hydrogen peroxide in southern England during a photochemical episode. Three clinical screening algorithms were constructed that detailed the diagnostic evaluation of the target population by using first-trimester or second-trimester ultrasound and appropriate serologies or first-trimester and second-trimester screening in combination. Epithelial to mesenchymal transition (EMT) is implicated in the progression of primary tumours towards metastasis and is likely caused by a pathological activation of transcription factors regulating EMT in embryonic development. In contrast, anisomycin induces T1 gene expression at concentrations which block translation completely.

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Due to rapid progression of the disease, intraarterial perfusion of liver was repeated three months later with the same results. Quantification of F2-isoprostanes as a biomarker of oxidative stress. Stimulation of cyclic AMP and progesterone synthesis by LH, PGE2 and isoproterenol in the bovine CL in vitro.

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The purpose of this study was to investigate potential differences in PET/CT caused by attenuation differences in bowel due to motion. In this study, we used IIF and WB techniques to evaluate the reactivity of six different immunoglobulin G monoclonal antibodies (MAbs) raised against Encephalitozoon hellem with six isolates of E hellem that originated from patients with acquired immunodeficiency syndrome.

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To determine which factors predict length of stay at a rehabilitation hospital for total hip and knee arthroplasty patients. To obtain genomic sequence for the targeted region on chromosome V, two local BAC (bacterial artificial chromosome) contigs were constructed and sequenced, which corresponded to parts of the homologous chromosomes of the diploid, heterozygous genotype P6/210. Persistent hyperinsulinemic hypoglycaemia of infancy (PHHI) is the most frequent cause of hypoglycaemia in infancy. Many studies have shown an increased expression of various proteases in the ectopic endometrium of women with endometriosis. To provide an overview and up-to-date information on the presentation and treatment of central nervous system (CNS) metastases, including brain metastases, spinal cord compression, and leptomeningeal metastases.

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Sinus node dysfunction with conduction disorders and lithium poisoning The influence of single doses of propylthiouracil on the kinetics of iodine accumulation by the thyroid glands of normal and hyperthyroid subjects. Reconstruction of these dominant frequencies is effected to isolate the climatic components. Most publications concerning RCC are based on retrospective analyses, including some larger multicentre validation studies and well-designed controlled studies. Hyaluronan production in human rheumatoid fibroblastic synovial lining cells is increased by interleukin 1 beta but inhibited by transforming growth factor beta 1.

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Food-processing approaches to altering allergenic potential of milk-based formula. The comparative effectivity of the five media has been discussed. Radiographic and radiochromic films were placed at the upper (and lower) surface of circular metal discs (diameter x thickness: 15 x 3.2, 48 x 3.2, 48 x 3.8 mm2) in a solid water phantom and were exposed perpendicular to radiation beams. In foals, iIGF-I gradually increased over the first 2 months of life.

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Determination of cerebral oxygen consumption and blood flow by magnetic resonance imaging. The melanin-concentrating hormone (MCH) precursor encodes MCH and a second peptide named neuropeptide EI (NEI) in mammals, neuropeptide EV (NEV) in salmonids and MCH gene-related peptide (Mgrp) in other fish. Tissues were obtained from patients undergoing tumour resection for various rare pancreatic or ampullary neoplasms (number of cases in brackets): ampullary adenoma (1), neuro-endocrine tumour (3), malignant fibrous histiocytoma of the pancreas (1), pancreatic cystadenocarcinoma (1), serous cystadenoma (1), and primary and metastatic adenocarcinoma of the ampulla (5) and pancreas (3). However, the capacity of diverse isocortical areas to differentiate connectional characteristics belonging to other isocortical areas has recently been questioned in several experiments using heterotopic transplantation paradigms.

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This calcium flux also appears to control a slow potassium current that is responsible for post-tetanic hyperpolarization. The pathology of necrotic enteritis of chickens following infusion of crude toxins of Clostridium perfringens into the duodenum. The roles of preliminary decompressive surgery and urgent resuscitation by vasopressors are discussed. Here, the ability of systemic (i.p.), intracerebroventricular (i.c.v.) and intrathecal ( morphine to inhibit mechanical allodynia were studied in a nerve ligation (L5, L6 nerve roots) model of neuropathic pain in rats.

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As early as 10 min after calcium addition to cultured primary mouse keratinocytes, GAP associates with tyrosine-phosphorylated proteins and translocates to the membrane. Specific patterns of change in cognitive biases over the course of depression as a function of major life stress support the etiological relevance of cognition in major depression. Those systems that are operational, have been implemented in narrow domains for particular applications. A common feature occurring in all these diseases is oxidative stress.

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Within the CMT1A xenografts, the nude mice axons in the proximal part of the graft showed a significant increase in axonal area with an increase in the neurofilament and membranous organelle (mitochondria) density, compared with distal graft and distal host segments. These results indicate that BGD treatment prevents the accumulation of platinum in the kidney after repeated administrations of DDP, resulting in protection against the DDP-induced renal toxicity. Treatment modalities for developmental dysplasia of the hip are variable.

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An elective-titration study of the comparative effectiveness of two angiotensin II-receptor blockers, irbesartan and losartan. The NO donor sodium nitroprusside (SNP) prevented the deterioration of RBC deformability in a dose-dependent manner with 10(-4) M being the most effective concentration. These differences may be linked to an upregulation of the TGFbeta and the Jun/Fos pathways in mutant keratinocytes. Our results indicate (226)Ra equilibrium is achieved in a natural population of lake herring (Coregonus artedii), contrary to predictions of the power function model. This new covered needle catheter reduces contaminating bacteria in patients who require endoscopic injection and may prevent bacteremia without antibiotic prophylaxis.

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Adverse food reactions in childhood: concept, importance, and present problems. Kasabach-Merritt syndrome secondary to diffuse angiomatosis of the colon. Mouse interleukin-1beta (mIL-1beta, 100 ng, i.p.) induced changes resembling those to LPS, a short-lived decrease in Tc, followed by a small increase.

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A reduced EOG light rise, previously suggested as a characteristic sign for ADVIRC, is not a typical sign for all affected patients. In patients with PAR to ASA, C5a-induced generation of sLT was significantly increased as compared to normal controls. After four weeks, the control cylinders (non-treated allogeneic bone) had been invaded by cellular tissue composed of lymphocytes and plasmocytes surrounding remnants of the donor bone marrow tissue. Finally, the interactions of HilA with the SPI-2 secretion system gene ssaH and the flagellar gene flhD imply a repressor function for HilA under invasion-inducing conditions.

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In the latter two cases, antibodies against synthetic peptides were also used. The relative rates of hydrolysis of cCMP, poly(U), poly(A), poly(C), and tRNA(Phe) by hepatitis Abs were compared with those of RNase A and other RNases from human blood. By creating a logical algorithm to follow in working up a neck mass, the primary care practitioner can both more rapidly arrive at the correct diagnosis and, if indicated, refer the patient to the appropriate specialist for any further care. Planosporicin selectively blocks peptidoglycan biosynthesis and causes accumulation of UDP-linked peptidoglycan precursors in growing bacterial cells. The involvement of the insulin-like growth factor (IGF) system in lung growth and repair following injury is sustained by a number of studies.

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The impregnated zone splits off entirely, leaving an area covered by pseudoblastema cells on the leech surface, which is progressively reepithelialized. In enamel prisms of developing teeth the Ca and P content increased linearly from the surface towards the enamel-dentin junction. This strain difference was not due to variation in maternal care, the phenotypic characteristics of stimulus mice or sensitivity to the length of isolation prior to testing, nor was it attributable to a general difference in appetitive motivation. Cerebromeningeal hemorrhages and their sequelae in congenital deficiencies of plasma hemostasis factors.

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Practical tools such as the Johari Window are presented to assist the reader in this process. Prognostic features in patients with stage T1 breast carcinoma and a 0.5-cm or less lymph node metastasis. Embolotherapy is an accepted form of therapy in adults with high-flow priapism. Adult Tfm males, wild-type male and female littermates were gonadectomized and given subcutaneous estradiol implants. During the review period, twenty-seven patients were identified.

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We have successfully developed a method for the immunohistochemical detection of interleukin 2 (IL-2), IL-4, IL-6, IL-10O, IFNgamma and TNFalpha using monoclonal antibodies (MAb), in sections of mouse tissue embedded in paraffin wax. Dissimilarity in the reductive unfolding pathways of two ribonuclease homologues. Objective criteria for reporting language dominance by intracarotid amobarbital procedure. Simple analytic bounds for the electronic energy from level set boundaries of nuclear charge space.

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Interval exercise alters feed intake as well as leptin and ghrelin concentrations in standardbred mares. Clinical findings at presentation, development of complications, interval between symptoms and treatment, recurrence of inflammation, use of intravenous corticosteroids, and method of tapering of systemic corticosteroids were significant prognostic factors. Furthermore, the inactivation of the population at temperatures above the maximum temperature for growth has been incorporated. Expression of the MCH gene predominates in hypothalamic neurons.

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The use of conceptual knowledge collections or structures within the biomedical domain is pervasive, spanning a variety of applications including controlled terminologies, semantic networks, ontologies, and database schemas. Indeed, tyrosine kinase-dependent phosphorylation of c-Cbl regulated the ubiquitin ligase activity of that protein, whereas PKC-dependent phosphorylation of c-Cbl had no such effect. Mutation 35delG is the most common mutation for sensorineural deafness.

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FSH receptors were found in this tumour, and on the basis of this finding, gonadotrophins were given to athymic nude mice in an attempt to support the growth of the granulosa cell tumour implanted in these animals. All three analogs are competitive inhibitors of NADH in reaction with chicken muscle lactate dehydrogenase, and the Ki values show little dependence on the nature of the amino substitution.

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Analysis of our series of kidney transplants: urologic complications and survival 636 women attending check up appointment for repeat prescription of the combined contraceptive pill. Informative criteria for a classification of laryngeal and hypopharyngeal tumors During the aerosol process, a silica shell was first formed due to the preferred silicate condensation on the gas-liquid interface of the aerosol droplet. Although deficiencies of iron, vitamin B12, and folate commonly result in anemia, bone marrow suppression of red blood cell production related to the direct toxic effects of alcohol can cause a form called sideroblastic anemia.

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Final assessment of the validity, reliability and sensitivity of this index is now underway. In this report, the effect of free and Elastin-like polypeptide (ELP) bound doxorubicin (Dox) on the viability of sensitive (MES-SA and MCF-7) and multidrug resistant (MES-SA/Dx5 and NCI/ADR-RES) human carcinoma cells was studied in vitro. Although the three known mammalian RAMPs differ in their sequences and tissue expression, results from in vitro biochemical and pharmacological studies suggest that they have overlapping effects on the GPCRs with which they interact.

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the lumen and exterior) as well as on cross-sections of the ePTFE to permit analysis of the pore surfaces. Association of vitamin D and estrogen receptor gene polymorphism with the effects of longterm hormone replacement therapy on bone mineral density. We did not observe an increase in the MN frequency with culture duration or proliferation rate of the tumor cells.

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In this study, urinary zinc and copper were measured in 27 healthy controls and 30 calcium oxalate stone formers. A promising alternative is the pantropic retroviral vector, which is packaged with the envelope glycoprotein from vesicular stomatitis virus and is replication-defective. Biological food contamination by allergic organisms occurring in the human environment

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pylori and has the advantage of a low incidence of side effects and quick pain relief for patients with active ulcers. The completion of the Saccharomyces cerevisiae genome sequencing project and the continued development of improved technology for large-scale genome analysis have led to tremendous growth in the amount of new yeast genetics and molecular biology data. Intracellular recordings in dark-adapted mudpuppy retinas have revealed a type of infrequently encountered cell with unusual response properties.

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The pregnant uterus showed strong expression of neuropsin mRNA, whereas the nonpregnant uterus did not express this mRNA. Selectin-mediated rolling is a prerequisite for firm adhesion and subsequent transendothelial migration of leukocytes into tissues. Neuroleptic drug therapy is a major component of the acute and maintenance treatment of schizophrenia. In this open-label study, patients demonstrating a clinical response to infliximab were switched to treatment with adalimumab and followed for 16 weeks. The study, thus, suggests that during a starvation-refeeding ciprapine tablets 2016 cycle the level of cAMP in the liver is regulated predominantly by the insulin/glucagon ratio in the blood.

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Using the yeast two-hybrid protein-protein interaction assay, we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1). Since bioactive F2-isoprostanes are continuously formed in various tissues and large amounts of these potent compounds are found unmetabolised in their kullandiniz dostinex uses free acid form in the urine in normal basal conditions with a wide inter-individual variation, their role in the regulation of normal physiological functions could be of further biological interest, but has yet to be disclosed.

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In the SC, components P(27), N(48), and N(53) were reduced in amplitude, while P(37) and N(57) were unaffected by nicotine. Classic transgenic and knockout murine models in which beta-catenin is activated in large fields of cells have provided experimental support in favor of a role for this kepinol forte wirkungsquantum molecule in tumorigenesis.

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Effect of transatlantic transport on reproduction of agouti and nonagouti deer mice, Peromyscus maniculatus. This is the first empirical study of adherence in this population. Structure, mode of action and biological role of ecto-nucleotide pyrophosphatase/phosphodiesterase enzyme family Pharmacokinetic study of omeprazole in elderly healthy volunteers. Our results show that contralateral tumors usually have major mammographic findings different from those of the first cancer, and the mammographic signs of the first cancer do not indicate the cyclophosphamide dosing hemodialysis training most likely appearance of cancer in the contralateral breast.

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Heparan sulfate proteoglycans have been implicated in the presentation of a number of secreted signaling molecules to their signal-transducing receptors. These mature DC might generate in vivo effective immune responses after injection, because they retain the ability to secrete bioactive indomethacin for gout flare symptoms IL-12 after CD40 ligation. Intracellular recordings were used to compare the electrophysiological properties of Purkinje cells in granuloprival cultures to those of Purkinje cells in standard cultures. It has been found that the state of experimentally produced insulin deficiency directly influences metabolism of the heart muscle and the changes observed in the histochemical reactions prove this.

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The relationship between obligatory cortical auditory evoked potentials (CAEPs) and functional measures in young infants. Removal of nitrogenous compounds by terazosin hcl side effects catalytic wet air oxidation.

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Spongiform transmissible encephalopathies are neurodegenerative diseases characterized by the accumulation, in infected brains, of a pathological form of a normal host-encoded protein called PrP. The most significant factor in the poorer prognosis is physician delay in diagnosis and therapy. To investigate the molecular inhibitron 40 mg capsulas de ajo basis for this altered expression we developed a comprehensive PCR/SSCP mutation screen for the human E-cadherin gene. The indications and results of elective partial splenectomy in children remain uncertain.

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When human fibroblast, TIG-1, was nausetil 5mg prochlorperazine maleate brand growth-stimulated with fetal bovine serum, the induction level of cell cycle-dependent genes was generally much lower in senescent cells than in young counterparts. Data were collected in a group of 66 breast cancer patients by self-report questionnaires. Activity of the transcription factors interacting with regulatory elements SRE, DSE, TRE did not correlate with the c-fos expression level in all the cells. Protein A-peroxidase: a valluable tool for the localization of antigens.

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Guidelines for the safe handling of excreta contaminated by cytotoxic agents. During infections, impairment of intestinal calcium but not of phosphorus absorption results in an increased phosphorus and renal net atorvastatina tevagen 40 mg acid excretion. Myocardial bridging of coronary arteries: A risk factor for myocardial fibrosis?

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