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Geranylgeranyl reductase expressed in Escherichia coli sequentially catalyzes the reduction of geranylgeranyl-chlorophyll a into phytyl-chlorophyll a as well as the reduction of free geranylgeranyl diphosphate into phytyl diphosphate. At a high temperature of 80 degrees C, prophenol oxidase was partially denatured. Women with FIGO stage III or IV epithelial ovarian cancer were primarily treated with escalating doses of doxorubicin in combination with paclitaxel (135 mg/m2 over 24 h) and cisplatin (75 mg/m2) every 3 weeks. We report a case of extrafoveal choroidal neovascularization (CNV) secondary to neovascular age-related macular degeneration treated with photodynamic therapy (PDT) and intravitreal triamcinolone.

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Natural pollen extracts from nine different monocot species were characterized regarding their allergen contents by using specific antibodies and by IgE immunoblot inhibition with recombinant allergens. Subjects performed both a visually guided ramp tracking task using wrist flexion/extension and a whole arm circle tracking task using shoulder movement.

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The concentration-response curve for 5-HT was not affected by tetrodotoxin (0.3 microM), guanethidine (5 microM) or indomethacin (2 microM), suggesting that the relaxation is non-neuronal in origin and is independent of the release of catecholamines or prostanoids. HPE is genetically heterogeneous with at least 6 different chromosome regions containing genes involved in the expression of the phenotype. Identification of differentially expressed proteins and its applications of isolated proteins Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis.

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Radiographs obtained at follow-up were rated for deformity and signs of arthrosis, using a score described by Reswick and Niwayama. The 15 patients who received clindamycin had the most rapid response to therapy and a change of therapy and surgical drainage was required in one case. Blindness reduces the life expectancy of those affected and has an enormous socioeconomic impact on these communities. The positive influence of Aloe vera, a tropical cactus, on the healing of full-thickness wounds in diabetic rats is reported.

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This study indicates that in vivo 31P MR spectroscopy provides valuable information for assessment of testicular function. However, in neither experiment was easy preexposure more effective than hard preexposure in enhancing learning of the hard discrimination. Physical therapy of any individual shall be administered only by a licensed physical therapist. Two cases of isolated glycerol kinase deficiency with heterogeneous neurological symptoms.

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iap genes function to protect cells from undergoing apoptotic death in response to a variety of stimuli. The type of GBS was determined according to Asbury and Ropper criteria, and its correlation with pathological findings was studied. Human SDF-1alpha and SDF-1beta bound with a high affinity (K(D)s of 12.0 and 10.4 nM, respectively) to human cells stably expressing feline CXCR4, and treatment of CrFK cells with human SDF-1alpha resulted in a dose-dependent inhibition of infection by FIV(PET). Considering the present health policy, health service and health care systems, health condition and health demands of the people, proclaimed priorities in biomedical scientific research in the Republic of Croatia, and expected health and disease status in the first decades of the 21st century, the author raises the question of sensitization of the Croatian physicians and the public to new ethical challenges. It has been previously shown that lesions of the dorsal striatum can disrupt performance on a variety of cognitive tasks related to frontal cortex function.

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Even within a species like Escherichia coli, stress resistance is not constant between strains, suggesting that selection for stress resistance is under counterselection in some environments. Identification of novel substrates for human checkpoint kinase Chk1 and Chk2 through genome-wide screening using a consensus Chk phosphorylation motif. DNA stimulates Mec1-mediated phosphorylation of replication protein A.

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Coadministration of atropine did not affect basal levels in the presence of 10 nM neostigmine, but increased acetylcholine levels approximately four and 11-fold in the presence of 100 nM and 1000 nM neostigmine, respectively. Delayed-interval delivery in a quadruplet pregnancy after intrauterine death of a partial molar pregnancy and preterm delivery.

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When a smoker stops smoking, the level of serum thiocyanate decreases and falls to the level observed in non-smokers after about one month. The survey instrument included the Conflict Tactics Scale to measure aggressive and violent behavior. Reporting two cases of true herpetic encephalitis, the authors insist on the great diagnostic value of some nearly constant, but transitory, aspects of localised periodic waves in the E.E.G. Sensory ERPs predict differences in working memory span and fluid intelligence.

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Treatment of cells on fibulin-5 with a beta1 integrin-activating antibody induced stress fibres, increased attachment, migration and proliferation, and stimulated signalling of epidermal growth factor receptor and platelet-derived growth factor receptors alpha and beta. After a comprehensive evaluation 44 patients with recent onset (less than 3 years) of erectile dysfunction and a high likelihood of organogenic etiology underwent a prospective, double-blind and placebo controlled trial with oral phentolamine after placebo.

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Germ-line sequences were also found in six in vivo and five in vitro passaged MPCs and in four in vivo transplanted RICs. This effect was mimicked under the same conditions by 5-carboxamidotryptamine but not by alpha-methyl-5-hydroxytryptamine or 2-methyl-5-hydroxytryptamine. The raising of the intracellular pH of ciliates by this antibiotic may be linked to its toxic action and its iontransport mechanism in Tetrahymena.

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Since the debate still exists whether cisplatin-based and carboplatin-based chemotherapy are equally effective for advanced non-small-cell lung cancer (NSCLC), a meta-analysis of trials was performed to compare the cisplatin-based with carboplatin-based regimens in first line chemotherapy of advanced NSCLC. Six VP2-specific monoclonal antibodies recognized determinants common to both the empty capsids and native parvovirus.

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Prevalence of the burnout syndrome among Brazilian medical oncologists. Almost two thirds of the women who had had a live birth reported breast feeding.

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18F-fluordeoxyglucose scan with a conventional dual-head gamma-camera is a highly sensitive and specific method in the differential diagnosis of benign and malign pancreatic masses. A robust method for determining the magnitude of the fully asymmetric alignment tensor of oriented macromolecules in the absence of structural information.

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MUC1 is a transmembrane mucin that plays an important role in tumor progression. Expert Workshop of the Curatorium on Immune Deficiency, Munich, 15-17 October 1998, Weimar In these cases, applying the within-sire family transformation improved the detection when the number of progeny per sire was greater than 100. Pulmonary complications following cardiopulmonary bypass--a retrospective study.

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A preliminary treatment with N-alpha-RNPs resulted in decreasing K562 cell sensitivity to splenocyte cytotoxicity, whereas pretreatment of the splenocytes themselves exerted no cytotoxic effect. Sequence diversity patterns and phylogenetic analyses reveal the existence of a relict lineage (Clade A) of late Miocene origin, comprising populations from south-eastern Serbia.

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The visual field appeared to be reduced compared with that of the 4-mm lens. Analysis of mutation frequency following continuous and fractionated application of ethyleneimine and ethyl methanesulfonate to male sex cells of Drosophila melanogaster Biotinidase deficiency (late-onset multiple carboxylase deficiency) The new anti-cancer drug imatinib mesylate inhibits the tyrosine kinase growth factor receptor, c-KIT, and has shown spectacular activity in patients with gastrointestinal stromal tumours (GISTs). Extra-pulmonary findings included hepatocellular necrosis and steatosis, widespread severe fibrinoid necrosis in lymphoid organs, marked lymphocyte loss and karyorrhexis, and neuronal degeneration in brain.

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Acute neurobehavioural effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Han/Wistar rats. Anthropogenic subsidies alter stream consumer-resource stoichiometry, biodiversity, and food chains. The TTV 2 group was separated into four main branches, two of which included sequences previously provisionally attributed as TTV types 2 and 3. Arsenic trioxide (As2O3) therapy at a daily dose of 0.15 mg/kg was given to a 60-yr-old Japanese male with refractory acute promyelocytic leukemia. Cleavage furrows regress after completion of mitosis in cyk-1 mutants, leaving multiple nuclei in a single cell.

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