This medication is a nonsteroidal anti-inflammatory drug (NSAID), specifically a COX-2 inhibitor, which relieves pain and swelling (inflammation). It is used to treat arthritis, acute pain, and menstrual pain and discomfort. The pain and swelling relief provided by this medication helps you perform more of your normal daily activities. If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section. This drug works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used to treat gout attacks.

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The characteristics of human plasma lipoprotein metabolism: influence of low caloric diet on hyperlipidemia. Protein kinase-mediated phosphorylation of a purified sterol ester hydrolase from bovine adrenal cortex. RN lesions additionally abolished the arpeggio movement by which the paw is oriented for searching and grasping.

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The optimal management of clinically localized (T1, T2) prostate cancer remains controversial. These functional analyses prove that oct-TKRPs, but not oct-TK-I, serve as endogenous functional ligands through oct-TKRPR, although both of the family peptides were identified in a single species, and the importance of C-terminal Arg-NH2 in the specific recognition of TKRPs by TKRPR is conserved through evolutionary lineages of Octopus. In each stem, mutations that would interfere with Watson-Crick base-pairing also reduced the first-order rate constants by 10-10(4)-fold relative to the unmodified version.

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Upstream sequencing and functional characterization of the human cholinergic gene locus. The importance of so-called oncological standards is stressed every time an innovation is introduced in surgical practice. Diurnal rhythms in cyclic nucleotide metabolism in Helix nervous system. Observation of the heliumlike Ti XXI emission lines from Doublet-III tokamak plasmas. To report the 6-month anatomic and best-corrected visual acuity (BCVA) response after primary intravitreal bevacizumab (Avastin) in patients with diabetic macular edema (DME).

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Analogy between lymphotropic human retroviruses and large animal retroviruses. Risk as analysis and risk as feelings: some thoughts about affect, reason, risk, and rationality.

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To study this relationship, three groups of age-matched rats were used: normotensive Wistar-Kyoto rats 6, 15, and 20 weeks, of age, and spontaneously hypertensive rats (stroke-resistant spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats) 6, 15, and 20 weeks of age. However, when diets were changed to the standard diet, compensatory growth was observed. Temperature propagation in near-critical fluids prior to and during phase separation.

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Epithelial cell adhesion molecule (KSA) expression: pathobiology and its role as an independent predictor of survival in renal cell carcinoma. Neonatal lupus erythematosus: an unusual congenital presentation with cutaneous atrophy, erosions, alopecia, and pancytopenia. Computerized patient model and simulated clinical experiences: evaluation with baccalaureate nursing students. From 1976 to 1996, 221 patients were treated with external radiotherapy (XRT) and/or low-dose-rate brachytherapy (BT) followed by surgery (S). The differences between two databases describing the polypeptide main chain in terms of charge-density parameters, directly usable in protein structure refinements, are discussed.

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Male and female rats received nimesulide or its vehicle twice daily, for 5 days, and were killed on the seventh day for the isolation of liver mitochondria. This ORF was believed to be encoded a trans-acting replication factor. These 38 mutations have been localized onto a factor VIII A domain molecular model. Finally, experimental infection of rodents, horses and primates with West Nile virus has been integral to developing and evaluating the efficacy of West Nile virus vaccines. Fourteen of these fractions were subjected to amino acid sequencing.

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In this study, we demonstrated that LAT is present in platelets and is tyrosine phosphorylated in response to ADP- and thrombin-stimulated aggregation. In the five soils, soluble Cd was found to be very labile, soluble Ni and Pb were mostly non-labile, Mn and Zn lability depended on the soil, while Cu had a fraction of moderately labile forms in four of the five soils.

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Existing reports have not documented the risk factors of sepsis during TPN. To evaluate the efficacy of transcatheter arterial embolization for pulmonary arteriovenous fistula (PAVF).

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Baseline currents in these cells were generally small and increased up to 30-fold within 10 min following the onset of swelling. By contrast, in 3 cases, rabbit sperm pretreated with antisperm Fab were able to fertilize in vivo with successful pregnancy in a control and isoimmune doe resulting in normal offspring. We developed and have clinically used an applicator that enables simultaneous intraluminal irradiation and hyperthermia delivery for the treatment of locally invasive esophageal carcinoma. The opportunities offered by some known and validated targets are, however, by far not exhausted. Influence of phlebotomy on iron-related gene expression levels in the livers of patients with chronic hepatitis C.

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At the end of the treatment the Extensor digitorum longus muscles were dissected from treated and control rats and their passive and active electrical parameters were analyzed in vitro by standard microelectrodes technique. Mitral and tricuspid valve repair with artificial chordae in children demonstrated acceptable results. avium-intracellulare infection in individuals without predisposing lung disease. With previous therapies (diuretics, beta-blockers, etc.), good BP control in the elderly was associated with clear and statistically significant reductions in stroke-related morbidity and mortality, but the overall effects on cardiovascular and renal complications of hypertension was either more variable or less obvious.

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Patients with malignant, unresectable biliary strictures and endoprosthesis or stents for drainage often develop liver abscess. The enzyme-linked immunoassay has the ability to distinguish anticancer drugs from toxic chemicals, to predict selective toxicity to cancer cells, and to detect drug synergism.

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Matrix metalloproteinase-2 expression and activity increase significantly at days 3 and 8. Increased Notch1 signaling induced a downmodulation of human papillomavirus transcription through suppression of activator protein (AP)-1 activity by upregulation of c-Jun and the decreased expression of c-Fos. A series of 27 patients with 37 trigger digits were observed over a period of 18 years: the average follow-up on these patients was 46.9 months.

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Fourteen day postinfection IgG antibody-positive sera obtained from individuals infected with DEN-1 virus who had been vaccinated with other flaviviruses were more strongly reactive with the cell culture antigen than with the recombinant antigen, but by day 21 postinfection, a strong antibody response to the trpE-DEN antigens was present. The cantilever oscillates at its mechanical resonant frequency, 70.36 kHz, which is much faster than its thermal time constant of 300 micros, and so the cantilever operates in thermal steady state. The efficacy of the worked out springs and rings were successfully proved in several clinical applications. In the low transmission area, lower infection levels are reflected in lower parasite-specific antibody levels (of all isotypes) in the community as a whole. Tamoxifen inhibits colorectal cancer metastases in the liver: a study in a murine model.

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So close is this relatedness that the hybrid peptide pairs LtnA1:C55beta and C55alpha:LtnA2 were found to have activities in the single nanomolar range, comparing well with the native pairings. Tuberculosis is an important cause of mortality due to its high prevalence, considering that one third of the worlds population is infected with the tuberculosis bacillus. Feline leukemia virus infection: age-related variation in response of cats to experimental infection. Comparison of immunodeficiency and AIDS defining conditions in HIV negative and HIV positive men with haemophilia A. To determine whether lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, and bestatin, an aminopeptidase inhibitor with broad specificity, could affect collagen production in control and transforming growth factor (TGF)-beta1-treated cardiac fibroblasts.

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A positive correlation was found between high Fe levels and vascular involvement. Results in the present study for the first time suggest that DHMC induces apoptosis in human lung A549 cells through partial inhibition of ERK/MAPK signaling. To evaluate the effects of these population movements on the current genetic landscape of the Iranian plateau, the Indus Valley, and Central Asia, we have analyzed 910 mitochondrial DNAs (mtDNAs) from 23 populations of the region.

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This relatively simple approach should be used for the treatment of obstruction before radical surgery is performed. To test the hypothesis that in a healthy pediatric population body mass index (BMI) (kilograms per meter square) is a valid measure of fatness that is independent of age for both sexes. The gene for myotonic dystrophy (DM) has recently been isolated and amplification of an unstable CTG trinucleotide repeat, located within the DM gene, has been identified in virtually all patients studied to date.

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This review critically evaluates current knowledge of alpha-linolenic acid metabolism in adult humans based on the findings of studies using stable isotope tracers and on increased dietary alpha-linolenic acid intake. Studies on the 14.5 nm meridional X-ray diffraction reflection during length changes of intact frog muscle fibres.

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In the series B, the effect of vagotomy on the ulcer healing and accompanying changes in GBF were determined at day 8 and 16 after ulcer induction. Combination of a nonanalgesic dose of nefopam (10 mg/kg) with a nonanalgesic dose of morphine (0.3 or 1.0 mg/kg) completely inhibited carrageenan- or incision-induced thermal hyperalgesia, respectively. Unrestrained 30-ns molecular dynamics simulations of the ATP-bound, ADP-bound, and apo states of the MJ0796 monomer support the idea that interaction of a conserved glutamine residue with the catalytic metal mediates the rotation of the helical subdomain in response to nucleotide binding and hydrolysis. As yeast lacks this enzyme, we have introduced the rat GnT-I cDNA into yeast cells.

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Rapid detection of Pfcrt and Pfmdr1 mutations in Plasmodium falciparum isolates by FRET and in vivo response to chloroquine among children from Osogbo, Nigeria. The patients in group I were all treated by full sheet skin grafts using a two-component fibrin glue. Coincidence of lower antiperoxidation ability and higher peroxidation of membrane phospholipid indicate myocardial cell vulnerability in SHR hypertrophied myocardium. Lastly, they tend to have a relatively high risk for some cancers which are likely to have a viral etiology: e.g., nasopharynx (Italians and Near Easterners), liver (Near Eastern males), and possibly cervix (Moroccans).

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Auditory speech processing in the left temporal lobe: an electrical interference study. International Diabetes Federation: a consensus on Type 2 diabetes prevention. Stomata and plant water relations: does air pollution create problems?

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Upon transfection, wild-type T beta R-I restored the TGF-beta signals for growth inhibition and production of plasminogen activator inhibitor-1 (PAI-1) and fibronectin. Can antibiotic residues modify the human gut flora, and select drug resistant bacteria? These findings suggest that stimulus processing at the level of primary representations in area SI is modulated by attention. Evidence that a Gq-protein mediates excitatory odor transduction in lobster olfactory receptor neurons.

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The status of apoptosis was evaluated by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) technique. Human T-cell leukemia virus type 1 Tax protein induces the expression of lymphocyte chemoattractant SDF-1/PBSF. Results in the present paper indicate that gallic acid is considerably more active than tannic acid. Tools should be rigorously developed, evidence-based, valid, reliable and easy to use. The flagella connector represents a novel form of cellular junction that is both dynamic and mobile.

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A 68-year-old female was diagnosed with a renocolic fistula, associated with left chronic pyelonephritis due to a ureter stone. Effects of high glucose concentration and a thromboxane synthase inhibitor on the production of thromboxane A2 and prostaglandin I2 and E2 by retinal endothelial cells. Critical currents at the bragg glass to vortex glass transition.

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Neurological changes due to lesions of the central and peripheral nervous systems were revealed. A rational approach to benign prostatic hyperplasia evaluation: recent advances. Tumor necrosis factor alpha (TNF-alpha) converting enzyme (TACE) is a zinc metalloprotease that has emerged as a general sheddase, which is responsible for ectodomain release of numerous membrane proteins, including the proinflammatory cytokine TNF-alpha, the leukocyte adhesin L-selectin and epidermal growth factor receptor ligand-transforming growth factor alpha (TGF-alpha), and related family members. Here we present evidence that the first intron of the hGH-N coding region contains a novel eukaryotic promoter which is able to direct the expression of hGH-N and luciferase reporter genes.

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One hundred ten consecutive patients at a vascular laboratory had brachial and ankle Psys measured with the two methods. Protective effects of lycopene against ultraviolet B-induced photodamage. The challenges of staffing urban schools with effective teachers. Analysis of the activities of the Kanev Stomatologic Center in 1996