Ezetimibe and Avas combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Avas is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Avas/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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The vast majority of abdominal incisions used in gynecologic surgery are either transverse or vertical midline. Comparison between fine needle aspiration (FNAB) and automated coaxial core biopsy (ACCB) of CT-guided thoracal and abdominal biopsies. The spectrum of podocytopathies: a unifying view of glomerular diseases. Structured analysis of intracellular calcium oscillations in electrically non-excitable cells

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In contrast to prevailing assumptions, the study findings reveal that most patients undergoing elective major intracranial surgery will experience moderate to severe pain for the first 2 days after surgery and that this pain is often inadequately treated. The tri-exponential drug concentration decay complicates the definition of therapeutic dosage regiments and prevents straightforward prediction of recovery from drug effects.

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Pfcrt haplotypes and in-vivo chloroquine response in Sundergarh district, Orissa, India. Photoelastic analysis of stress distribution on the tibiofemoral joint after meniscectomy. These events were unaffected by inhibition of prostaglandin synthesis, whereas bradykinin (BK(2)) receptor blockade was associated with abolished vasodilation and inhibition of mucosal mast cell degranulation. Randomised controlled trials of two different doses of the same ICS in adults and children with asthma with no concomitant ICS or OCS.

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We now report studies of intermolecular reactions with ribozyme and target sequences expressed in yeast as separate chimeric U3 snoRNAs. jejuni genotyping methods and emphasizes the potential of HRM for genotyping short sequence repeats in other species. Determinants of abnormal maximum oxygen uptake after lung transplantation for chronic obstructive pulmonary disease. The reduction potential of cytochrome b5 is modulated by its exposed heme edge. These systems represent different host responses to viral infection, i.e., one in which both cellular transformation and viral replication occur (B-77-infected duck cells), one in which viral replication, but not transformation, occurs (Rous-associated virus-61-infected duck cells), and one in which transformation, but not viral replication, occurs (B-77-infected 3T3 cells).

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CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Giant cell myocarditis is a rare cause of cardiac failure and should be considered in the differential diagnosis in view of its clinical features and risk of progression. In the bowel proximal to the obstruction, the lymphatic space area was increased in the diatrizoate group and the size of the epithelial cells was higher in the diatrizoate and iohexol groups compared to the barium and saline groups.

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Physical examination revealed long-standing plaques on the face and upper limbs, papular lesions of the oral cavity and tongue firmness. The affected child presented a mild disturbance of the extrapancreatic secretory function followed by a marked decrease in the number of peripheral blood neutrophils and contracted respiratory infections repeatedly. Genetic and functional analysis of a set of HIV-1 envelope genes obtained from biological clones with varying syncytium-inducing capacities. However, the groups were matched on the naming speed measures when differences in reading ability were controlled. Adenoid cystic carcinoma was the most commonly seen tumor in this series of patients.

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The properties of human pancreatic lipase are described, especially as regards the influence of the kind and the presentation of the substrate, as well as the effects of bile pigments and colipase. The purpose of this study was (1) to determine whether preservation of diaphragm integrity has a significant effect on postoperative ventilator duration and (2) to elucidate other pulmonary risk factors related to thoracoabdominal aortic surgery and to study the relationship of these factors to the intact diaphragm technique.

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Normal controls only modestly improved their performance on repeat testing. DIABETES MELLITUS AS A SIDE EFFECT OF TREATMENT WITH TRICYCLIC NEUROLEPTICS. Recently, it has been discovered that the motor cortex perceives motor actions. Multiple isoforms of thyroid hormone receptor: an analysis of their relative contribution in mediating thyroid hormone action. On the other hand, l-AMP is used by T4 DNA ligase to catalyse the reverse reaction, even though a high level of intermediate circular nicked DNA molecules accumulates.

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Two subjects had significant cerebral perfusion abnormalities prior to the expedition, which had improved immediately following their return from the expedition. In view of the fact that, simultaneous administration of both drugs may alter the antihypertensive effect of captopril, present paper deals with the in vitro availability studies of captopril in presence of commonly used H2-receptor antagonists like cimetidine, ranitidine and famotidine. Plasmid pIPO2 mobilized IncQ plasmid pIE723 from Pseudomonas fluorescence to diverse indigenous proteobacteria in the rhizosphere of field-grown wheat. PLA2-IIC mRNA was expressed in all brain regions but not in any of the peripheral tissues studied.

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Alkaline phosphatase in Drosophila melanogaster strains differing in male mating activity and their F1 hybrids Generic instruments will continue to be important for economic evaluations, but transplant-specific instruments may be more useful for patient management purposes, as they are generally more sensitive to small but clinically relevant changes in outcomes in transplant populations.

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Unique peroxidase reaction mechanism in prostaglandin endoperoxide H synthase-2: compound I in prostaglandin endoperoxide H synthase-2 can be formed without assistance by distal glutamine residue. In one instance, the gus sequence was fused, in inverse orientation, to the nos promoter sequence of a truncated tandem T-DNA copy and translated from a spurious ATG in this sequence. Twenty hips corresponding to strictly Ficat stage II underwent magnetic resonance imaging and the volume of necrotic bone was expressed as a percentage of the volume of the entire head measured on each slice.

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Neonatal handling reduces the stress-induced blood pressure rise in adult NISAG rats and modulates the structure of the adrenal cortex and medulla. Replication terminator protein-based replication fork-arrest systems in various Bacillus species. MSCs have similar drug resistance mechanism to the tumor stem cells. The first dose of a Haemophilus influenzae type b conjugate vaccine reactivates memory B cells: evidence for extensive clonal selection, intraclonal affinity maturation, and multiple isotype switches to IgA2. (ii) Does labelling with PKH26 alter cellular proliferation characteristics?

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To our knowledge, the present patient is the 6th case in the Japanese literature and the first case with incidentally detected renal hemangiopericytoma. Solvation of uranium hexachloro complexes in room-temperature ionic liquids. A suction instrument was utilized in 24 ears and was not used in 27 ears. Detection of adenine in paper chromatograms of nucleoprotein hydrolysates

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Comparison of prevalence, service use and excess costs in South Australia: 1998 and 2004. These results demonstrate that orf14 of HVS is not required for replication but is required for transformation and for high-level persistence in vivo. While deep venous thrombosis and pulmonary embolism are the most common thrombotic conditions in patients with malignant disease, tumor thrombus may be seen in inferior vena cava, mainly in patients with renal cell carcinoma, hepatocellular carcinoma, testicular tumors or adrenal carcinoma. Relation of mycophenolic acid trough levels and adverse events in kidney allograft recipients. For example, in one series of three calves, one ventricle exhibited significantly greater thrombogenesis than did the other ventricles, as indicated by both the LSMD and CPF results.

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Influence of combined, hypolipemic therapy on lipids and non-lipid atherosclerosis risk factors Structural study of the DNA duplex containing a site-specific photoproduct is an essential step toward understanding the molecular mechanism of the mutagenesis and the repair activity of UV-irradiated DNA. The clinicoradiologic findings were noted, and the fine-needle aspiration (FNA) slides were available for review in 8 patients.

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It is suggested, that sex steroids on the late stages of PFC formation, when the processes of isotype antibody synthesis switch take place, appear to be synergists of CG immunodepressive effect. Regulation of de novo purine biosynthesis in normal and 8-azaguanine-resistant Chinese hamster cells. The preoperative diagnosis was lateral cervical, or branchial, sinuses.

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Noninvasive quantification of the cerebral metabolic rate for glucose using positron emission tomography, 18F-fluoro-2-deoxyglucose, the Patlak method, and an image-derived input function. Appropriate dietary manipulation may be beneficial in the prevention of recurrent urolithiasis in only a select group of patients.

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One outcome of T-cell receptor (TCR) signaling is increased affinity and avidity of integrins for their ligands. How homologous recombination is initiated: unexpected evidence for single-strand nicks from v(d)j site-specific recombination. Current status and issues in hematopoietic stem cell transplantation Although many advances in antineoplastic therapy have taken place, a clinical breakthrough in the therapy of malignant gliomas is still required.

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In addition, it may be difficult to persuade the patient that a specific drug is responsible for their skin problem. Layer IV was composed of proteoglycans, and layer V consisted of protein alone. Trans-sphenoidal pituitary exploration is a technique which can be performed with low operative morbidity and mortality, and when instituted early can prevent subsequent visual and endocrine impairment from an expanding lesion. Because this is a malignant type of meningioma, early diagnosis and surgical intervention are important in the management of patients. When either the hand or target was not visible, the aperture closure distance systematically increased compared to its value for the same amplitude of peak aperture, hand velocity, and acceleration under full visibility.

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The performance of the columns was evaluated in both mu-HPLC and capillary electrochromatography (CEC) of small aromatic compounds and polycyclic aromatic hydrocarbons with 10 mM borate, pH 8.0, in acetonitrile-water mixtures as the mobile phase. These characteristics, if operative in vivo, would contribute towards the optimal function of trans-cellular metabolism of eicosanoids already demonstrated.

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Both antibiosis and nonpreference (antixenosis) are important mechanisms of resistance in sweetpotato genotypes. The veterans reported a high level of social anxiety and agoraphobia-like symptoms. For this purpose, we combined the acetylation method, providing an excellent distinction between the various nucleolar components, with the in situ terminal deoxynucleotidyl transferase-immunogold technique, a highly sensitive method for detecting DNA at the ultrastructural level. Our conjugation strategy is based on non-covalent self-assembly between DHLA-capped QDs and protein appended with either an electrostatic attachment domain (namely, the basic leucine zipper) or a polyhistidine tag.

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Esophagectomy is a very invasive operation, therefore, it is important to improve the postoperative quality of life (QOL) of the patients. We also examined whether extracellular signal-regulated protein kinase (ERK) and p38 MAPK, which are known to regulate activation of NF-kappaB, can also modulate CREB DNA binding.

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Cognitive, perceptual, and motor abilities in skilled basketball performance. We test it on 97 representative proteins with the similarity measure based on the SCOP classification. Synthesis of the exopolysaccharide ethapolan on a mixture of energy-deficient growth substrates A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes. To evaluate the impact of punctal occlusion on ocular tear clearance and occurrence of epiphora in patients with conjunctivochalasis (CCh).

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A 22 year old male with infectious mononucleosis, who stated a history of trauma to his left thoracic wall, developed an acute abdomen with symptoms of shock. A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells. Generation of carboxy-terminally deleted forms of STAT5 during preparation of cell extracts. The deduced amino acid sequence of oapB has similarity to a consensus sequence for bacterial lipoproteins. We investigated three groups of hospitalized patients considered at risk for ongoing brain injury resulting from a prior cerebral insult: successful resuscitation from out-of-hospital cardiac arrest (CA), subarachnoid hemorrhage (SAH), or traumatic closed-head injury (CHI).

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The relationship between granule-NAD(P)H oxidase and myeloperoxidase. Report of another family with Simpson-Golabi-Behmel syndrome and a review of the literature. Our findings indicate that the acid secretory response of the canine stomach to histamine does not require prior accumulation of cyclic AMP in the mucosal tissue.

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Although there is much to learn about the production, function, and mechanism of action of connective tissue growth factor, some progress has been made in understanding the molecular basis of its relationship with transforming growth factor-beta. However, the process is more complicated than its principle suggests due to different transport phenomena interfering with electrophoretic migration, with the resultant separation depending both on separation effects and dispersive phenomena. These were based on a Transtheoretical Model and incorporated into the Adherence Model.

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The corporal bodies and glans remained hypoplastic whereas the urethral spongiosa was more developed than the wild type female counterpart. Cells were cultured for 6 and 10 days and examined for total DNA, alkaline phosphatase activity, and osteocalcin and total protein production. The cellular prion protein PrP(C) is the normal counterpart of the scrapie prion protein PrP(Sc), the main component of the infectious agent of transmissible spongiform encephalopathies (TSEs).

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The article summarizes the results of epidemiological observation which was performed in one of the training units. A significant difference between sexes was found in the linear skeletal measurements but not in the angular measurements for both ethnic groups.

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Inducible alpha-galactosidase activity and melibiose transport activity were detected in the mutant cells but not in the wild-type cells. Five tissue blocks were scanned with a synchrotron radiation-based microtomography (microCT) scanner and sample-specific finite element models were generated. This report summarizes the clinical features of her illness and the subsequent investigation by CDC in response to a technical assistance request from the Occupational Safety and Health Administration (OSHA) and presents interim recommendations to prevent ocular splash exposures. Calculating the maximum clique for a graph is a highly relevant issue not only on purely computational grounds, but also because of its relationship to fundamental problems in genomics. All patients examined with EBUS and real-time NA to measure and sample mediastinal and lobar nodes for lung cancer staging during one year were included, independently of the size of the mediastinal nodes at computed tomography (CT).

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Randomised clinical trials of all types of conservative treatments for patients with the lumbosacral radicular syndrome selected by two reviewers. Many cytokines and all known matrix proteinases are glycoproteins and thus occur as sets of glycoforms.

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Diets rich in carbohydrate may be associated with slightly higher blood pressure than diets rich in cis-monounsaturated fat. Revisions were performed in 27 patients (due partially to cholesteatoma, and/or poor visualization of radical mastoidectomy cavities). Structural and energetic studies of the wild-type and K12M mutant show that the 1.9 kcal mol(-1) increase in stability is not due to native state effects, but rather is caused by modulation of specific non-native electrostatic interactions in the denatured state. Production of LTP at perforant path-granule cell synapses was significantly larger in NELL2-deficient mice than in wild-type controls.

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Our purpose was to determine whether human trophoblast has a cell surface CD4 antigen that will bind to gp120, the envelope protein of human immunodeficiency virus. Toxocara eggs in the soil of public places and schools in Basrah, Iraq. Thus, there does not remain any doubt that intracytoplasmic A particles in murine mammary tumors are MTV-related. The increased concentration of nonpancreatic synovial-type phospholipase A2 in serum was associated with pulmonary and renal complications. The p53 gene of the parental PGE cells was found to be overexpressed, perhaps thereby conferring the basal potential for long-term survival in vitro.

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In both the USA and UK, we recommend exploration of regionalised care, akin to US state trauma systems, and greater use of physician-extenders, such as nurse practitioners, to provide enhanced access to specialist care for critical illness. Their differences reside in the way the physical correlations between the amino acids and the conformational states are extracted from the bulk interactions due to the presence of many residues in a protein. This study was designed to characterize the mechanisms regulating the expression of the human carcinoembryonic antigen promoter (pCEA), in terms of tissue-specific targeting for gene therapy. This is the first report representing that augmented proliferation of donor AM in situ may contribute to the reconstitution of AM population after BMT.

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The effect of the drug was due to its spasmolytic and antiaggregatory activities. Our aim was to find out if this product is material-specific as stated by its manufacturers or whether its effects are similar when the promoter is used with other adhesive systems. A PCCC significantly reduced PCO formation within the central 3.0 mm eccentricity as well as the need for Nd:YAG laser capsulotomy in eyes with a single-piece hydrophilic acrylic IOL with angulated haptics. Phosphorothioated antisense c-myc oligonucleotide inhibits the growth of human colon carcinoma cells. The highest prevalence of childhood overweight was found in Eastern Europe and the Middle East, whereas India and Sri Lanka had the lowest prevalence.

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Swainsonine caused a great distortion to the vasculature at 18 weeks. A significant increase of urinary polyamines was also observed in tumor-bearing rats. The p19s of two other RAV-60 isolates had electrophoretic properties that were different than those of p19s from either RAV-0 or the exogenous viruses.

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The West Point nomenclature was developed to clearly describe the various forms of humeral avulsion of the gleno-humeral ligament lesions encountered as well as their associated injuries. These interactions initiate a fusion of the viral and cellular membranes. In crushed nerves, in which axons regenerate and are remyelinated, periaxin is first detected in the adoxonal membrane as Schwann cells ensheathe regenerating axons, but again prior to the appearance of other myelin proteins.

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We hypothesized that compliance in pediatrics would be poor because of the intrinsic difficulties in performing invasive procedures in small subjects. Additional follow-up data were obtained using outpatient examinations, questionnaires, and telephone calls. There were highly significant correlations between plasma androstenedione and ACTH both in baseline and post-DST conditions.

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Double contrast barium studies are a valuable tool in the demonstration of this spread, showing good correlation with CT staging findings. To examine the influence of photodynamic therapy (PDT) with verteporfin on the indication and frequency of conventional thermal krypton laser photocoagulation in choroidal neovascularization. An Al-Qaeda terror plot to use cyanide gas in the London Underground was foiled in 2002.