Broflex is used along with other medications to treat the symptoms of Parkinson's disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and to control extrapyramidal symptoms (tremor, slurred speech) caused by certain medications. Broflex is in a class of medications called antimuscarinics. It works by relaxing muscles and nerve impulses that control the function of muscles.

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Nicorandil may suppress premature ventricular contractions when they occur mainly at a low heart rate. Flow cytometric analysis of nuclei from frozen tissue revealed that the lesion was DNA aneuploid, with a DNA index of 1.28. The minimal C-terminal truncation required for the acquisition of catalytic competence has yet to be defined, however, and it remains unclear as to why truncation is needed. To elucidate the function of AM secreted from EC, the effects of 43 substances on secretion of AM from cultured rat EC were examined in this study.

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A Sarcocystis-like organism was associated with encephalitis and myocarditis in an ataxic, emaciated adult male turkey (Meleagris gallopavo) from Gilmer County, West Virginia. Changes in the conformationally-sensitive amide I band upon phosphorylation indicated an increase of the alpha-helical content with a concomitant decrease of less ordered structures such as turns and random coils, and without changes in beta-sheet content.

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An unusually large motif of approximately 60 nucleotides is responsible for binding in one RNA (SRB-2). The continuously growing knowledge about criteria important for biology, pathogenesis, prognosis and treatment of acute myeloid leukemia (AML) necessitates a broad spectrum of diagnostic methods for first diagnosis and for the further course of the disease. Midcervical flexion myelopathy is a rare but well-known complication of posterior fossa surgery. Here, we analyze different putative roles of the VirE2 protein in the plant cell.

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The spoIIE locus is involved in the Spo0A-dependent switch in the location of FtsZ rings in Bacillus subtilis. The apical surfaces of the cells lining the intra- and interlobular ducts were also stained by all the lectins. The decreased relapse rate after cure of the infection is the most compelling argument in favour of the infectious etiology of peptic ulcer disease. Management of severe anaphylactic reactions should include administration of alpha adrenergic agonists. These results support the concept that preeclampsia is associated with metabolic aberrations found in insulin resistance syndrome.

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Consonant-recognition scores were compared to scores predicted by a modified articulation index. Food intake is controlled by the arcuate nucleus through integration of peripheral hormonal signals such as leptin, ghrelin, peptide YY (PYY), and glucagon-like peptide 1 (GLP-1). To investigate and compare the prevalence of pharyngeal reflux (PR) events in normal controls and patients with clinically diagnosed reflux laryngitis. Recent studies of the cloned sodium bile acid cotransporters have provided new insights into their tissue expression, regulation, and their relationship to cholesterol homeostasis and human diseases such as primary bile acid malabsorption. Expression constructs were also generated for each amino terminal isoform to investigate the patterns of localization of individual isoforms and the effects on cells of ectopic expression.

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The biotransformation of gentiopicroside by asexual mycelia of Cordyceps sinensis yielded two products, one of which was proved to be a new pyridine monoterpene alkaloid. As the waiting time for donor hearts grows, new generations of left ventricular assist systems are being developed for patients awaiting transplantation.

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Discrimination of cell-wall mutants from wild-type was independent of variability in starch content or additional unrelated mutations that might be present in a heavily mutagenised population. Twenty-seven patients underwent 1.25 mg intravitreal injections of bevacizumab at baseline. A 39-year-old woman sustained an irreversible hearing loss in the left ear, followed 6 months later by a left facial paresis.

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The net result of this effort should be a great improvement in the power and availability of bioinformatics resources to the general biology community. Additionally, following immunostaining, a particular subcellular localization (present in organelles) is proposed for this antigen. N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. Cardiology was consulted to evaluate for a cardioembolic source.

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Differential packaging in CCVs in the TGN, mediated by tyrosine- and dileucine-based sorting signals, could be a mechanism for functional segregation of DM from DR-I chain until their intended rendezvous in late endocytic compartments. The employer did not classify those workplaces as workplaces with special working conditions. From determined external pelvic measurements only the hip breadth provides usefull informations of the pelvic shape. MLH1 and MSH2 constitutional mutations in colorectal cancer families not meeting the standard criteria for hereditary nonpolyposis colorectal cancer.

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Our experiments establish that small peptides containing the consensus DECD sequence of sperm fertilinbeta bind specifically to an alpha6beta1 integrin receptor on the egg membrane. In the advent of acquired immune deficiency syndrome (AIDS), high risk behaviours are investigated with the view to applying the results towards the formulation of policies on prevention of intraprison transmission of human immunodeficiency virus (HIV). HA production in the synovial lining cells of inflamed joints (for example, rheumatoid arthritis) might be regulated by the balance of these cytokines. Enterococcal bacteremia in children: a review of seventy-five episodes in a pediatric hospital.

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Changes were significantly attenuated after the second exercise bout. Apoptosis in microencapsulated juvenile rabbit chondrocytes induced by ofloxacin: role played by beta(1)-integrin receptor.

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The most frequent spontaneous bleeding symptoms were epistaxis and haemarthrosis, and the most frequent traumatic bleeding symptoms were bleeding after dental extraction and bleeding after cutting any part of the body. They are particularly useful in those refractory to medical management and in those who are unable or unwilling to undergo neurosurgical treatment.

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Together, the data reveal a new role for a class II RNase III in the cell cycle and suggest that at least some members of the RNase III family possess catalysis-independent functions. Tryptophan fluorescence quenching by vesicles containing brominated phospholipids indicated that the EBO(GE) peptide penetrated to the acyl chain level only when the membranes contained phosphatidylinositol. Limited in its direct application to binary mixtures, isobolographic analysis provides a conceptual framework and an unambiguous terminology, as well as an algebraic paradigm for the analysis of the interaction of ternary and higher order mixtures. The prediction of mortality in severe head injury is of interest for the evaluation of patient prognosis and to also permit therapeutic measures to be considered and improve knowledge of this problem.

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Strategies for eliminating PrP(c) as substrate for prion conversion and for enhancing PrP(Sc) degradation. Interactions with SH3 domains play a crucial role in regulation of many cellular processes (some are related to cancer and AIDS) and have thus been interesting targets in drug design. (18)F-FDG PET has proven invaluable in the staging of patients with metastatic colorectal cancer. To investigate how long fetal germ cells retain pluripotency, which may be linked to their ability to transform into histologically variable tumours, we examined the expression of OCT-3/4 (POU5F1), a transcription factor essential for the maintenance of totipotency in embryonic stem cells.

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This drug decreased left ventricular developed pressure and maximum rates of contraction and relaxation, but had no effect on heart rate and end-diastolic pressure. Physical examination revealed an elastic hard mass, with marked tenderness in the right abdominal region.

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Binding sites for the cellular p53 protein located within the NRE appeared to contribute to NRE function, and NRE function could be recapitulated in cotransfection assays by concomitant expression of p53 and HCMV IE2-86 protein. Clarification of concept, clinical application and current state of empirical research

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The severity of TRUS abnormalities was graded on a scale developed by the authors. A rare cervical spine abnormality associated with neurofibromatosis. The effects of several treatment parameters, including dose, number of exposures, interval between exposures and duration of exposure, on the development, magnitude and duration of desensitization following local treatment with capsaicin and related compounds are described. The reason for this could in part be explained by an inhibition of activity occurring in the original water sample.

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To reduce the symptoms low-fat diet should be tried, as well as administration of HMG-CoA-reductase inhibitors or, if necessary, surgical liposuction. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. Lymphocyte reconstitution after allogeneic blood stem cell transplantation for hematologic malignancies. Salmon testis is a good source of DNA nicking--closing (N--C) enzyme, as expected for rapidly proliferating cells.

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pgaE encodes a fourth member of the endopolygalacturonase gene family from Aspergillus niger. AMPA-type glutamate receptors mediate the majority of fast excitatory transmission in the central nervous system. The force in the SDFT trotting or cantering uphill is unchanged or lower than that loaded at the same speed on a flat surface.

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Left ventricular function after mitral valve replacement with or without chordal preservation. We used an anonymous written survey at three family medicine clinics. However, immunohistochemical staining of the murine brain vasculature in aldehyde fixed tissue has proven elusive and inconsistent using current protocols. Results from logistic regression analyses indicated that the predictors of not reporting also varied across crime types. Simian adenoviral pneumonia can be a spontaneous disease problem in laboratory-reared primates and offers excellent potential as an animal model of human adenoviral pneumonia.

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Productive maturation of these proteins relies on an ER-resident protein called mesoderm development candidate 2 (MESD) in mammals and Boca in Drosophila. On the experimental distinction between ssbs and dsbs in circular DNA.

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Human cytomegalovirus: a review of developments between 1970 and 1976. During platelet activation, as revealed by electron microscopy, the secretory organelles become centralized and enveloped by circular microtubules and a filamentous network. Within all subgroups examined, subjects in the Web-based tailored intervention were more likely to report 10-week continuous abstinence at 12-week follow-up.

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To further investigate this possibility, wild-type and vitamin-C-deficient Arabidopsis thaliana (L.) Heynh (vtc) plants were transformed with a 35S: GLOase construct, homozygous lines were developed, and vitamin C levels were compared to those in untransformed controls. In vitro evaluation of the accuracy of five different electronic apex locators for determining the working length of endodontically retreated teeth. The conversion of D-ribose into D-ribose 5-phosphate by extracts of Escherichia coli.

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Endogenous DC and copper-induced MDA levels were also measured in the LDL fraction isolated by precipitation with buffered heparin from plasma in 80 healthy subjects with different serum LDL-C levels. Nkx2-5 is also expressed in the developing foregut, thyroid, spleen, stomach and tongue. Emotionally negative stimuli are resistant to repetition priming.

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Is laparoscopic radical nephrectomy with specimen morcellation acceptable cancer surgery? Laparoscopic surgery of benign small and large intestinal diseases The objective of this study was to determine the effect of either carbohydrate content or osmolarity on gastric emptying rate in normal healthy subjects.

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Phytotoxicity of washing wastewaters from a cutlery production line. On the other hand, NOS activity was detected in uterine strips and could be stimulated by PAF. The use of glass-ionomer cement rather than composite cement as the luting material resulted in more microleakage.

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The selectivity to ionic species is attained by adding metal-free top layers of polymer electrolytes to an LbL SERS enhancing substrate. Antimalarial activity of some plants traditionally used in Meru district of Kenya. Inelastic transitions in vibrationally excited Na2 induced by intermediate-energy-electron impact. Activity of pyruvate dehydrogenase (PDG), isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase was found in the extracts of the cells of Bac.

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New technological advances can be expected to help to determine the clinical usefulness of ambulatory testing during sleep and thus to establish the indications for polysomnographic investigations in the laboratory. A larger conductance was accompanied by a smaller value for gating and vice versa. Diabetes problem-solving scale development in an adult, African American sample.

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42 patients (34 men, 8 females) with invasive bladder carcinoma (clinical stages T1-4) were treated after transurethral biopsy with chemotherapy and concomitant external radiotherapy. Bystander CPR in first minutes after cardiac arrest appears to be a crucial component of the chain of survival. The molecular structures of the alpha-CD-OEI star polymers, which contained linear or branched OEI arms with different chain lengths ranging from 1 to 14 ethylenimine units, were characterized by using size exclusion chromatography, 13C and 1H NMR, and elemental analysis.

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The objective of this study was to assess the relationship between Epstein-Barr virus (EBV) infection and posttransplantation lymphoproliferative disease (PTLD) in pediatric heart transplant recipients. Cerebrospinal fluid norepinephrine alterations during electrical stimulation of cerebellar, cerebral surfaces in epileptic patients. The high incidence of melanoma antigen-encoding gene expression in lung cancer indicates the possibility of a future specific immunotherapy for this disease. Radiation safety, various laboratory policies, frequency of short stay, and outpatient procedures were tabulated. During combat activities in the territory of former Yugoslavia, in the period of 1991-92, they were exposed to intensive stress and psychotraumatic events which could have detrimental influence on personality and psychological functions, most frequently causing posttraumatic stress disorder.

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PROTEGE-II is a methodology and a suite of tools that allow developers to build and maintain knowledge-based systems in a principled manner. In recent decades we have been given insight into the process that transforms a normal cell into a malignant cancer cell. Lung reduction operation and resection of pulmonary nodules in patients with severe emphysema.

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In this paper, we will describe the results of our preliminary investigation and discuss its clinical significance. The immune response to soluble D10 TCR: analysis of antibody and T cell responses. The decline in the serum-antibody titre during the first year of vaccination could be eliminated by the use of the antigen in water-in-oil emulsion. To evaluate the test-retest repeatability of axial length (AL) measurements made with the IOLMaster in children with a wide range of myopic refractive errors, and to clarify the relationship between the AL and other refractive components. Older people also have a greater need for the use of health and social care (Department of Health (DH) 2001).

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Clinical presentation, surgical treatment, and pathological evidence are discussed. The purpose of this study was to detect differences in thoracic spine range of motion due to the placement of spinal staples manufactured from a common shape memory alloy. Preincubation of thymulin with an antithymulin serum completely quenched the secretagogue activity of the hormone. Infections with more than 100 human rhinovirus types are an important economic factor.

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In one of 28 instances, virus was recovered from blind-passaged, experimental, embryonic fibroblasts. We, therefore, randomized 49 chronic alcoholics, moderate to heavy drinkers for at least 10 years to receive oral magnesium or placebo treatment for 6 weeks according to a double-blind protocol. The molecular mechanistic and immunological properties of amine oxidases. Aseptic loosening of the acetabular component is the major long-term complication of cemented total hip replacement.

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Dose-response of ketorolac as an adjunct to patient-controlled analgesia morphine in patients after spinal fusion surgery. We have evaluated the patterns of diagnostic and treatment practices for benign prostatic hyperplasia (BPH) in a country that does not have country-specific clinical practice guidelines. The key properties of the glass-ionomer cements--fluoride release over a prolonged period and specific adhesion to enamel and dentine coupled with aesthetic qualities are related to their characteristics as aqueous polyelectrolyte systems. Both the mean albumin and mean total globulin of each group of subjects were significantly different from the respective means of the other three groups.

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Also, Val-hemizygotes had significantly increased grey matter density in cerebellum, brainstem, and parahippocampal gyrus, and decreased white matter density in the cerebellum. It was revealed that concordance of tissue array core biopsies in quadruplicate compared with full-section analysis for the expression and intensity of expression of MCAM. Hepatocyte growth factor (HGF) is known to have beneficial effects against damage in various organs, including liver, kidney and lung, in disease models. Impact of prior antiplatelet therapy on risk of embolism in infective endocarditis. It therefore constitutes an original and novel target for the development of anti-Brucella agents.

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Finally, we witness long-term adaptation to fluctuating environments not anticipated in previous theoretical work. Basal dendrites are transiently present on developing newly generated granule cells in adult rats. These advancements in the understanding of the activity of FGF-10 present an opportunity to engineer the growth factor as a therapeutic agent for the healing of damaged urothelial tissue. Our data show that select nuclear divisions of the amygdala project to the entorhinal cortex, hippocampus, subiculum, and parasubiculum in segregated rather than overlapping terminal fields. The data showed that applications of both EDTA and DNP resulted in reduced total Cd accumulation in the plants, but relatively enhanced Cd transport into the above-ground plant parts.

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The postlingually deaf adults are able to use the telephone and may be integrated in their original job. Such changes most likely occur in the constituents of bone, namely, the mineral and organic phases, and in their spatial arrangement manifested as orientation and microstructure. Four decades of systematic research shows that a rigid, bureaucratic command and control approach to emergency management generally leads to an ineffective emergency response.

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To evaluate the safety and efficacy of MMF in the treatment of severe childhood AD. Two statistical models were used to analyze preoperative, demographic, surgical, and postoperative variables and determine potential correlations. We first analyzed global gene expression in the lumbar spinal cord of uninjured male and female rats using the Affymetrix RAE230A GeneChip platform in order to identify genes that are selectively expressed in male and female rats at a basal level. Neither central AII nor cholinergic blockade alone affected drinking. Clearly, there is a need to identify and implement effective HIV prevention strategies among at-risk teens.

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We found that the initial burst of the chemiluminescence signal depended on the UVA fluence rate, whereas the decay of the signal following exposure can be related to the UVA dose involved. We use rigid cylinders to create a two-dimensional periodic lattice, in which liquid surface waves propagate. Regulation of the specific DNA binding activity of Xenopus laevis p53: evidence for conserved regulation through the carboxy-terminus of the protein. The data suggest that smoking and cardiorespiratory fitness are important mediating or modifying factors between structural and functional aspects of social network ties and plasma fibrinogen.