Caduet is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Caduet is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. Caduet may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Caduet is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Caduet has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

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Differences in the decrease in regenerative capacity of various brain regions of Xenopus laevis are related to differences in the undifferentiated cell populations. Even though the pancreatic secretion cannot be judged from these results they show that the enzymes respond differently to weaning. Environmental constraints upon locomotion and predator-prey interactions in aquatic organisms: an introduction. The wall of the germ tube arose from the innermost layer of the wall of the germinant. Characterization of neutralizing monoclonal antibody escape mutants of Hantaan virus 76118.

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Human eosinophils produce biologically active IL-12: implications for control of T cell responses. Of three doses under test (0.0025, 0.25 and 25 mg/kg), the preparation used in the first two doses exhibited immunostimulating action and in the third dose, immunosuppressing action.

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The study aimed to investigate the time-course of electromagnetic field (EMF)-induced effects on human cognitive and behavioral performance and on tympanic temperature. The difference in these imaging predictors in terms of overall survival and progression-free survival was tested for statistical significance by the log-rank test.

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Model parameter/calibration uncertainty for the chemical models and population sampling uncertainty were explicitly quantified. Starting from the commercially available D-mannosamine hydrochloride (5), gram quantities of both 1 and 2 can be prepared over five steps in about 2-3 weeks. Two groups are identified: core functions and supportive functions. Phorbol-12-myristate-13-acetate (PMA) induces megakaryocytopoeisis in human erythroleukemia (HEL) cells which is characterized by the increase in cell size, increase in nuclear polyploidization and expression of megakaryocyte marker, CD41.

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Our goals were to determine whether relapse is associated with disease progression and whether treatment end points can be refined. Crystal structure of the H256A mutant of rat testis fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase. Surgeons reported subjective improvements in operative bleeding, efficiency, and operative time in six of six patients after the administration of rVIIa intraoperatively. Pseudomonas stutzeri should be considered in the treatment of delayed-onset endophthalmitis.

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Using immunofluorescence and confocal microscopy, we show that the internalized receptors localize at a juxtanuclear compartment identified as the Golgi apparatus. Pediatric duodenal biopsies: mucosal morphology and glycohydrolase expression do not change along the duodenum. Isolation, sequence analysis, and biological activity of atrolysin E/D, the non-RGD disintegrin domain from Crotalus atrox venom. A highly ossified teratoma was diagnosed and surgically treated in a 2-year old girl. A 4-year-old boy with congenital pseudarthrosis of the tibia had two unsuccessful operative attempts for union.

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This latter outcome is consistent with the possibility that stimuli from a female become directly associated with sexual reinforcement during the course of sexual experience. Antibodies against platelet glycoproteins and antiphospholipid antibodies in autoimmune thrombocytopenia. Taking advantage of the 1C11 neuroectodermal cell line, endowed with the capacity to convert into 1C11(5-HT) serotonergic or 1C11(NE) noradrenergic neuronal cells, allowed us to ascribe a signaling function to PrP(C).

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A remarkably microheterogeneous pattern of increased fluorescence resulted from a critical level of incomplete cerebral ischemia. No group differences were found in rate of forgetting or susceptibility to proactive or retroactive interference.

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Conditional expression of an activated ras mutant in Balb/c-3T3 fibroblasts failed to stimulate S phase entry in the absence of plasma-derived progression factors, but did shorten the G1 interval from 12 to 6 h and abrogate the normal proliferative requirement for platelet-derived growth factor. The revision chart comprised 12 clinical and radiological items as proposed by Seringe. Coenzyme Q is reduced by diverse dehydrogenase enzymes mainly NADH-cytochrome b(5) reductase and NAD(P)H:quinone reductase 1. The beneficial impact of glutamine supplementation seems to be through effects on gastrointestinal mucosa rather than the host immune response.

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To understand the role of opioids and their receptors in chronic pain following peripheral nerve injury, we have studied the mu-opioid receptor in rat and monkey lumbar 4 and 5 dorsal root ganglion neurons and the superficial dorsal horn of the spinal cord under normal circumstances and after peripheral axotomy. All of these innovations will hopefully increase cure rates for lung cancer patients by maximizing the efficacy of adjuvant therapy.

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The differences between kappa statistic values within the expert panel group compared to the comparisons of performer versus expert panel were not significant. However, the perspectives of older persons on nursing home admission have been seriously neglected and under-reported.

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In ERI, male professionals/technicians, transport/communication workers, clerical workers and protective service workers showed a significantly higher prevalence OR, compared to managers, the two models giving different results. In affinity electrokinetic chromatography the retention factor, as in liquid chromatography, is useful for describing the migration behavior of the analytes, and is instrumental for assessing the affinity of an analyte for the pseudo-stationary phase. Evidence was obtained using the intestinal smooth muscle of the rabbit in support of the hypothesis linking mediation of the beta adrenergic system to papaverine effects. The importance of multidisciplinary collaboration on the professional and societal levels and, finally, government- and private sector-sponsored research are also presented. Lipopolysaccharide and pneumococcal cell wall components activate the mitogen activated protein kinases (MAPK) erk-1, erk-2, and p38 in astrocytes.

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One of insulin-dependent diabetes mellitus (IDDM) complications are bone mineral disorders called diabetic osteopathy. The stereochemical activity of the Bi lone-pairs was found to have a major origination from the primary interaction for the Bi 6s-O 2p antibonding orbital. The proliferation and differentiation of Msx-expressing cells in the dorsal precartilaginous domain of the vertebra are stimulated by BMP4, which acts upstream of Msx genes. Data were obtained on 13 families at Cherbourg Aboriginal Community in Queensland.

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The aim of the study was to evaluate the therapeutic effect of electro-acupuncture (EA) and hydrotherapy, both in combination with patient education or with patient education alone, in the treatment of osteoarthritis in the hip. The oral mucosa is not designed to provide a foundation for denture base and is called upon to function in a new environment. This may reflect differences in functional properties and the embryonic origin between skeletal and esophageal striated muscle fibers.

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The Milan Automated Neurobehavioral System (MANS) has been used in field studies to measure effects of toxicants on the central nervous system. In the control condition of the shape task, same letter pairs were identified faster than different pairs when they were presented to the right visual field. Activation of caspase-8 was required to induce apoptosis, which was amplified by alpha-TOS via cytochrome c release following Bid cleavage, with ensuing activation of caspase-9. The significantly lower bone volume and appearance of chondrocytes in the high dose nicotine group indicated that the bone regeneration of distraction osteogenesis was compromised by high dose nicotine exposure. The data suggest that children with IBD often have small bones for age because they have growth retardation.

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Previous reviews have discussed its production by preimplantation embryos and the evidence implicating it as an autocrine mediator in aspects of gamete and embryo physiology. Specimens of the resins were subjected to a regimen of mechanical brushing using measured amounts of paste on standard toothbrushes driven by a reciprocating device. Postpartum cerebral angiopathy is a rare condition that affects otherwise healthy women who have undergone a normal pregnancy followed by an uncomplicated delivery. These drugs were administered 105 min before the estimated time of induction of anesthesia and followed by treatment with oral atropine 0.03 mg/kg 60 min before anesthesia.

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These studies generally lack the necessary statistical characterizations to be useful in quantitative risk assessment procedures. Giant-cell arteritis of the female genital tract associated with occult temporal arteritis and FDG-PET evidence of large-vessel vasculitis. High resolution laser excitation spectroscopy of the B2E-X2A1 transitions of calcium and strontium monoborohydride.

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They were not detectable at the initial dilution (1:50) of the ELISA test. The investigation proves that the most severe progressive forms of community-acquired pneumonia also occur both in patients who have previously appeared to be healthy and in younger patients. N-Arachidonylethanolamine (AEA), a putative endogenous agonist of neuronal (CB1) cannabinoid receptors, is a substrate for N-arachidonylethanolamine amidohydrolase (AEA amidohydrolase), a serine amidase present in cell membranes. Progressive atrophy of cerebellum and brainstem as a function of age and the size of the expanded CAG repeats in the MJD1 gene in Machado-Joseph disease.

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Taking into consideration that hepatic PI 3-kinase activation is severely impaired in obese diabetic models such as Zucker fatty rats, it is possible that the mechanism by which a high-fat diet causes insulin resistance is quite different from that associated with obesity and overeating due to abnormality in the leptin system. Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. On the intercorrelation of some frequency and amplitude parameters of the human EEG and its functional significance.

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In case 2, we were pathology consultants and unable to evaluate the clinical appearance of the lesion. Epidemiologic and laboratory investigations of the hemorrhagic fevers and their etiologic agents provide lessons that may be used collectively as a paradigm of the nature of emerging and re-emerging infectious diseases. The reaction of lateral geniculate units to this input was studied in fast and slow relay cells as well as in interneurons.

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The successful application of fludarabine plus alemtuzumab, or fludarabine in combination with other cytotoxic agents, as preparative regimens for stem cell transplantation techniques is also covered. Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin.

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IDUS diagnosis was confirmed by surgery as the tumours were resected. The present study was designed to test the hypothesis that smoking is associated with epicardial coronary endothelial dysfunction and inflammation.

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Evaluation of tumor response through of morphometric measurements. Direct comparison of antigen production and induction of apoptosis by canarypox virus- and modified vaccinia virus ankara-human immunodeficiency virus vaccine vectors.

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The inherent difficulty in studying the in vivo effect of CsA in humans was circumvented by investigating stable end-stage renal disease patients who were preconditioned with CsA before their living donor renal transplantation. Mycotoxins and antifungal drug interactions: implications in the treatment of illnesses due to indoor chronic toxigenic mold exposures. Heat stress causes beneficial changes in high-energy phosphate metabolism in the rat heart subjected to cardioplegic arrest and ischemia.

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Treating homosexuality as a sickness: enlightenment is worrying. We carried out an observational study and prospectively determined anthropometrical parameters in 127 children aged 1 month to 4 years with invasive meningococcal infection seen in our inpatient facilities from August 1999 to May 2004. In particular, this article addresses the fundamentals of the Medicare fee-for-service reimbursement process as well as the factors considered in arriving at the valuation of radiologic services by Medicare. It is seen from both simulations and the rat data that our method has lower false discovery rates than those from the significance analysis of microarray (SAM) method of Tusher et al. Gram-negative anaerobic bacteria, particularly fusobacteria, spirochetes, and black-pigmenting organisms such as Prevotella intermedia are often found in diseased sites.

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Sequential histologic examination of enucleated eyes showed diffuse intraocular inflammation after viral inoculation. Hybrid artificial pancreas: islet transplantation inside membrane bioreactors. Indices of permeability typically obtained are transepithelial resistance or more formalized assays using Ussing chambers modified for cultured monolayers. Lipid islands in human gastric mucosa: morphological and immunohistochemical findings.

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This inevitably leads to adhesion formation and failure of gliding. Patients with MCS have a higher Injury Severity Score, ICP, and fluid requirements, but no increase in mortality. In the second phase, the same radiologists evaluated whether coronal multiplanar reformats could be used for primary interpretation of MDCT of the abdomen and pelvis in a separate but similar cohort of 100 consecutive abdominopelvic MDCT studies. Sixteen patients scheduled for transvenous cardioverter-defibrillator implantation were included in the study. Prognostic factors for survival of patients with bidimensionally measurable metastatic hormone-refractory prostatic cancer treated with single-agent chemotherapy.

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We have developed a protocol to quantitatively assay intracellular steady state levels of Rev Ag (Rev wild type and RevM10 proteins) by flow cytometry. A gastric tumor from a 27-year-old female showed the light microscopic features of glomus tumor. Polyacrylamide gel electrophoresis (PAGE) was used to analyze the denatured PCR products and haplotype linkage analysis was applied according to the relationship between bands and family members to determine the association between the phenotype of aniridia and PAX6 gene. PCNSL usually appeared as one or more well defined focal lesions, iso- or hyperdense to grey matter, with homogeneous enhancement following IV contrast injection. For example, TE1 cells are polarized and possess tight junctions at their borders, similar to those found in trophectoderm of the pre-implantation embryo.

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A 35-year-old woman presented with abdominal distension and a palpable liver mass. Postpartum depression screening improves recognition of the disorder, but improvement in clinical outcomes requires enhanced care that ensures adequate treatment and follow-up.

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Different isoforms of the leptin receptor (leptin-R) exist, including a long isoform (leptin-RL) with signalling capacity and short isoforms (leptin-RS) with unknown function. A central problem in genomic research is the identification of genes and pathways involved in diseases and other biological processes.

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Basal and luteinizing releasing hormone-stimulated gonadotropin secretion were studied in male rats made nephrotic with puromycin, and in pair-fed and normal control animals. Antiadrenergic treatment of antidepressant-induced excessive sweating in 3 patients. Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. In a separate paper, we have shown that Pin1 is a phosphorylation-dependent PPIase that can recognize specifically the phosphorylated Ser/Thr-Pro bonds present in mitotic phosphoproteins.

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To determine the prevalence of undiagnosed hearing impairment in people aged 60 years or over in a general practice setting. Histamine-releasing peptide is formed from albumin by stimulated rat mast cells.

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Using cartilage to repair bone: an alternative approach in tissue engineering. The results showed that both hydrolysis and transglycosylation were enhanced in the microreaction channel compared with the batch reaction. Increasing ozone exposure resulted in reduced shoot dry weight, stimulated (first year) or reduced (second year) height growth, accelerated autumn yellowing of leaves, increased stomatal density, visible symptoms and chloroplast injuries, and increased number and size of plastoglobuli. P300 latency was longer in patients with newly diagnosed epilepsy than in control group.

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The expression of matrix metalloproteinase (MMP) was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) and zymography. The results show that the neurones of the central nucleus of the inferior colliculus do not react differently to self-produced and group mate vocalizations of the same type. Five of the six patients treated had relief within a few days to a week following gamma knife radiosurgery.

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With the exception of the patient with no evidence of rectal polyps, completion proctectomy should be undertaken within 10 years of the initial colectomy. The consistency of back-calculation and cohort data in haemophiliacs supports the use of back-calculation to estimate prevalence in other populations. These results suggest that impairment of neurogenic and NO-mediated relaxation in the aged corpus cavernosum possibly results from the down-regulation of nNOS protein. Black scorpion (Heterometrus longimanus) as a laboratory animal: maintenance of a colony of scorpion for milking of venom for research, using a restraining device.

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In elective cases, reconstruction is suggested, if possible in one step. The role of surface components, including LPS, pili, and capsule, in F. In some patients with SE the treatment with ceftriaxone may be completed under outpatient conditions. Mice were killed and their livers obtained at 2, 4, 6, 9, 10, 15 and 18 months, whereas rats were killed and surgical biopsies were taken at 16, 19, 26, and 36 months. Thus, antibodies with such specificities may be relevant in preventing the establishment of HCMV-associated disease or in modulating its progression.