Acarbosa is used (with diet only or diet and other medications) to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Acarbosa works by slowing the action of certain chemicals that break down food to release glucose (sugar) into your blood. Slowing food digestion helps keep blood glucose from rising very high after meals.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

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The sensitivity of adenylate cyclase to its usual effectors in vitro was not impaired. Mixed lymphocyte reactions were performed in naive gld, lpr, and wild-type animals, 6 and 12 weeks of age.

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Relevance of tissue distribution studies and cytopharmacology: utility of radioassay combined with autoradiography. Methods currently employed in common Grid middleware distributions are also reviewed and assessed in relation to the goals of KnowARC. The results emphasized the diagnostic utility of FNA biopsy material for morphologic and molecular analysis without compromising conventional cytologic and immunocytochemical analysis, and that prospective molecular testing of FNA specimens has utility in routine practice although it is subject to many of the same limitations that impact molecular analysis when applied to conventional tissue biopsy specimens. Lysophosphatidylcholine (lyso-PC), a biologically active phospholipid, appears to modulate various endothelial cell functions through tyrosine kinase-dependent signaling pathways. The diagnosis is often missed, and overlooked cuboid fractures can lead to severe alterations in foot mechanics and function.

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Expression of c-Fos was used to assess neuronal activity in the locus ceruleus. Furthermore, isolates capable of attachment but with little or no cytotoxicity toward HeLa cells had no detectable host cell-bound 65-kDa proteinase. Cyclic AMP and cyclic GMP accumulation in vitro in brain regions of young, old and aged rats.

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Light-responsive cells did not show a daily rhythm in baseline firing rates in either species, but rat SCN cells that did not respond to light were more active spontaneously during the subjective day. Furthermore, we compared the coding sequence(s) (CDS) of both splice variants for 12 different breeds, screened them for single nucleotide polymorphisms (SNPs) and characterised a basic expression pattern. The expression of the transgene in adult mice recapitulated the widespread, stable, and high-level expression of the thrombomodulin gene in vascular endothelium. Growth factors and cell kinetics: a mathematical model applied to Il-3 deprivation on leukemic cell lines. Accessory navicular bone: when ankle pain does not originate from the ankle.

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We have investigated the effect of endothelin (ET)-1, ET-3 and ET-(16-21) on isolated and perfused rat kidney (IPK). All the other sibs had the patterns different from each other and from the MZ ones. To investigate the efficiency and tolerance of PDT in refractory verrucae vulgares. Participants also completed mood questionnaires and the Automated Neuropsychological Assessment Matrix (ANAM) throughout the course of the day. Plasposons: modular self-cloning minitransposon derivatives for rapid genetic analysis of gram-negative bacterial genomes.

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Although the importance of natriuretic peptides is still being assessed, data from animal studies strongly support an important role fore these hormones in cardiovascular homeostasis. We demonstrated the generality of semisynthetic epitope construction with 13 diverse kinases: JNK1, p38alpha MAPK, Erk1, Erk2, Akt1, PKCdelta, PKCepsilon, Cdk1/cyclinB, CK1, Cdc5, GSK3beta, Src and Abl. However, the failure to demonstrate the activities of Cp and Wp may have been due to the limited sensitivities of detection approaches used.

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Analysis of rat liver samples showed that ethanol consumption significantly increased IL-6Ralpha messenger RNA and protein expression in females as compared with similarly treated males after 2 and 4 weeks. Intercellular contact, communication, and transmission of contractile forces between myocytes appears to play a primary role in remodeling the 2-dimensional cell layer into a parallel alignment of elongated myocytes with highly developed intercalated disk-like junctions. All the patients showed a reduction of the acromial-humeral distance when the sling was applied with strapping. The relationship between the reaction of the nasal mucosa to body work and temperature is discussed.

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The initial pathological diagnosis was adenocarcinoma of the parotid gland. Ocular oscillations were analyzed in 22 patients with OPT, 20 from focal brainstem lesions, with or without cerebellar lesions, and two from the progressive ataxia and palatal tremor syndrome. Finally, the distribution of nuclei in enzymatically dissociated myocytes was evaluated. Reactivation of chick erythrocyte nuclei after fusion with enucleated cells. Comprehensive gas chromatography GC-MS analysis of hyd1 in comparison to fk reveals an abnormal accumulation of unique sterol intermediates in each case.

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None of the identified proteins has a known acrosomal origin, which further indicated that there was no sample contamination with secondary ZP binding proteins from the acrosomal matrix. Given to mental status examination evaluates the general performances of cerebral cognitive function, it becomes indispensable to a comprehensive neurological examination accordingly. Differentiating cells undergo programmed alterations in their patterns of gene expression, which are often regulated by structural changes in chromatin. Urodynamic studies have proven helpful in determining the type and management of lower urinary tract dysfunction.

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Experiments were performed to indentify the series elastic component (SEC) in intact dog carotid artery held at in situ length. Age-of-dam adjustment factors are used to preadjust birth and weaning weight data for national beef cattle genetic evaluations.

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Florida finds a practical solution for a vexing problem: a new form enables terminally ill patients and/or their legal designates to assure that EMTs respect their right to refuse resuscitation. The purpose of this paper is to provide a description of the pervasive yet often poorly appreciated role of informatics in improving the process of data assembly, a critical task in the delivery of pharmacometric analysis results. The Authors report their surgical experience in patients with uninodular goitre, and stress the trends in management benign and malignant lesions. Prognostic significance of p21WAF1/CIP1, p27Kip1, p53 and E-cadherin expression in gastric cancer. Some novel cyclic operating modes of counter-current chromatography have been suggested.

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Two compounds, theophylline and 8-aza-9-furfuryl-adenine (SQ 4665), were found to maximally stimulate lipolysis in preparations of rat epididymal fat cells in the absence of exogenous hormones. Guided bone regeneration (GBR) has been used extensively since its introduction in the late 1980s. In several experiments the effect of PSK was attenuated to a greater degree when high numbers of cells were injected. In order to study the mechanism by which aldosterone and renin acitvity are suppressed in low-renin hypertension, 25 patients (13 normal-renin hypertensives, 10 low-renin patients including 4 non-responders and two DOC excess hypertensives) were investigated as inpatients. Effect of re-utilization of cuprophan capillary dialysers with different liquids on their biocompatibility and effectiveness of elimination

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Important factor is the effectiveness of dysplasia surveillance as a population based strategy to decrease colorectal cancer mortality in inflammatory bowel disease patients. The emphasis of treatment must be on preventing the problem from developing, which begins within hours of the injury.

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Relationship of renal size, body size, and blood pressure in children. These proteins significantly increase the number of known apoptotic suppressors. nasometry) is recommended, particularly when dealing with children who are more prone to develop symptoms with aging.

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The objective of this paper is to investigate the statistical properties of such a mid-point imputation approach. The conjugate SP-CTA stimulates adenylate cyclase in cultured cells that are transfected with either the NK1 or NK2 receptor, but not the NK3 receptor. Determination of absorption characteristics of AG337, a novel thymidylate synthase inhibitor, using a perfused rat intestinal model. After preoperative chemotherapy and irradiation therapy, the mandible had been resected from the second incisor on the right side to the first molar on the left side, and had been reconstructed with a titanium plate and a vascularized rectus-abdominis compound flap.

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This is the first record of natural human infection with Centrocestus in Thailand. Maximal shear stresses and maximum pressures (for an ostium width of 2 times the radius of the parent artery) were typically found at the downstream site of the ostium, rather than at the dome of the aneurysm.

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Evaluation of lactate measurement in blood and plasma with biosensor technology: a comparison of methods The rate of release of cyclic AMP by sheep ovaries containing a corpus luteum was determined at different stages of the cycle before and up to 60 min after an intra-arterial (ia) injection of 500 IU human chorionic gonadotrophin (hCG). Up-regulation of D cyclins occurs through an increase in the steady-state levels of mRNA, concomitantly with the activation of Brachyury and Goosecoid, two early markers of mesoderm differentiation. This paper is a renewed call for medical schools to address the societal need for more primary care physicians.

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The isolation of Mycobacterium africanum from a mediastinal lymph node with tuberculous alterations of a young bull from a herd of cattle in Northern Bavaria is described for the first time. In agreement with the overrepresentation of amino acid biosynthesis genes in this cluster, Gcn4p, a regulator of amino acid metabolism, was shown to be required for normal biofilm growth.

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The results presented here and those previously reported (de Groot, A., Krijger, J.-J., Filloux, A., Tommassen, J., 1996. High doses of Ag can paradoxically suppress immune responses in vivo. Nevertheless, liver tumors and cultured hepatoma cell lines proliferate in the presence of C/EBPalpha. The purpose of this study was to gain a better understanding of the use of complementary therapies among patients with inflammatory bowel disease. At 30 days after transplantation, distress and neurocognitive functioning were assessed.

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Dislocated fractures of the forearm frequently cause problems because of their poor reduction and retention. Long term metal movement in soils over a covered metalliferous waste heap at Parc lead-zinc mine, North Wales. The objective of this study was to determine fibronectin levels in umbilical cord blood of infants of diabetic mothers (IDM) and evaluate a possible correlation with perinatal pathology.

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Since NPY is the most potent naturally occurring orexigenic signal and the PVN is an important initial site of NPY action in the stimulatory pathway regulating feeding, our findings of augmented PVN NPY release in vivo and in vitro are in accord with the hypothesis that increased NPY secretion in the PVN may be responsible for hyperphagia in diabetic rats. It has been shown that COMT is genetically polymorphic with a wild-type and variant form where a valine has been substituted with a methionine.

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Fetal hydrops in the first trimester associated with maternal parvovirus infection. concentration of plasma proteins, albumin and non-esterified fatty acids, did not account for the low levels of free tryptophan in depressed patients. Tau isoforms generated by splicing differ from one another by having either three or four repeats in their C-terminal half, and a variable number of inserts in their N-terminal moiety.

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In some long-term cultures of gliomas and neurinomas an increasing polymorphism is observed by which these lines gain the morphological appearance of a glioblastoma multiforme. Rap1 small GTP-binding protein has the same amino acid sequence at its effector domain as that of Ras.

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Out of 51 contact lens wearing group, 41 were asymptomatic lens wearer subjects and 10 were symptomatic lens wearer subjects having some complications. Oligoscreening of a cDNA library obtained from 4 beta-phorbol 12-myristate 13-acetate-stimulated human erythroleukemia (HEL) cells resulted in the isolation of a novel clone coding for a protein with a calculated molecular mass of 8110 Da. The influence of dressings and ointments on the qualitative and quantitative evaluation of burn wounds by ICG video-angiography: an experimental setup. Changes in the epidemiological pattern of Mycoplasma pneumoniae pneumonia The roles of cortical F-actin in initiating and regulating polarized cell expansion in the form of hyphal tip morphogenesis were investigated by analyzing long term effects of F-actin disruption by latrunculin B in the oomycete Saprolegnia ferax, and detecting localized changes in the cortical F-actin organization preceding hyphal formation.

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We report the first case of a brainstem hemorrhage due to a hemangioblastoma of the medulla oblongata. Culex quinquefasciatus (Say) and Aedes aegypti (L.) were parenterally infected with dengue viruses and virus replication was monitored at intervals after infection in each species.

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The risk of hepatocellular carcinoma is increased with benign obstruction of the hepatic inferior vena cava (IVC). We have identified neurons in the CC of the cat and quantified their number at different postnatal ages. By using permeabilized cells, we previously described that the control exerted by the granule-bound Go on exocytosis may be related to effects on the cortical actin network through a sequence possibly involving Rho.

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Results indicate significant differences in the prescription of blood glucose monitoring strips, with patients initiated on insulin prescribed almost twice as many test strips compared with patients initiated on orals. The results show an absence of relationship between tumorigenicity and expression of MHC-class-I antigens, cell adhesion to rat fibroblasts or fibroblast extracellular matrix. An array of fiber-optic chemosensors, constructed with response properties similar to those of olfactory sensory neurons, provide time-varying inputs to a computer simulation of the olfactory bulb (OB). Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives. Furthermore, the dynamic replacement process may be driven by a positive equilibrium due to the increased stability of the alpha-internexin network.

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Biological supportive treatment of cancer patients, with special reference to jaw-face carcinoma Infectious diseases showed a considerable change in their epidemiologic significance during this century. Spectral integrity, evaluated by recording UV-absorbance spectra of the extracted filter molecules and molecular integrity, assessed indirectly via quantification of UV-A induced PC peroxidation, revealed that spectral stability of filter molecules alone or in combination (e.g. Oligodendrogliomas can display a spectrum of histologic and ultrastructural features.

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Infection accounts for the majority of pediatric mortality and morbidity in developing countries, but there are limited data on the infectious diseases burden in children from developed countries. Radial electronic density functions for selected low-lying excited 2S states of the Li I isoelectronic series. Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis. Alpha1PI also potentiated IgE and IgG4 production by IL-4-stimulated peripheral blood mononuclear cells but was not a switch factor for IgE and IgG4 as it was unable to replace IL-4 or anti-CD40 mAb in inducing IgE and IgG4 production.

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Here we report, for the first time, the isolation and the purification of an endoPG (PehA) from the supernatant of the plant pathogen Burkholderia cepacia strain ATCC 25416. Innervation zones of the external anal sphincter in healthy male and female subjects. The relaxed estimation procedure is shown to yield useful efficiency gains when moderate or strong disease rate dependencies are present, especially when disease rate variances are large relative to binomial variance. Effect of several antibiotics on bacterial dehydrases and fumarase

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Mass spectrometry, immunoblotting, and immunoprecipitation experiments confirm the stable association of this protein within SAGA. The peptides contain redox-active ferrocene (Fc) and thiol-functionalized cystein (Cys) at the N- and C-terminals, respectively. Expression of the cDNA and purification of P0 ribosomal protein from Lupinus luteus. Clone P1-9 spans approximately 65 kb of the NF1 gene, including exons 2-11, and clone P1-12 carries approximately 55 kb of NF1 intron 27B. They also have the effect that prevalence estimates, the most commonly used measures of infection in communities, can seriously mislead.

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Clinical phenotypes related to lipid and glucose metabolism were evaluated during dietary loading (17 g of fat, 750 Cal) and glucose loading (75 g glucose). These levels increased two- to three-fold in the pathologic conditions studied. Conventional electron microscopy, in various staining conditions, selective cytochemistry for DNA, and freeze fracture for the analysis of chromatin fiber organization and size were performed. A randomised placebo-controlled clinical trial of an acupressure device for weight loss. In contrast, all Bence Jones proteins tested showed detectable amidase activity against carbobenzoxy-L-valyl-glycyl-L-arginine p-nitroanilide.

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Aggregated cells were essentially nonmitotic but dye exclusion indicated high cell viability. Contracting for general practice: another turn of the wheel of history. Shedding of anti-IgM from antibody-coated human lymphoma lines: differences between Epstein-Barr virus-negative lines and their virus-converted sublines. The primary objective of this study was to determine the maximum tolerated dose of UFT/leucovorin and gemcitabine.

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Her major symptoms were mild weakness, pain on passive movement of the shoulder and hip girdles, with mild tenderness but no joint stiffness. Accurate quantitative determinations are often difficult to obtain from fluorescence analysis of complex samples due to sample matrix effects and intermolecular interactions between solutes.