Activir is used to treat infections caused by certain types of viruses. It treats cold sores around the mouth (caused by herpes simplex), shingles (caused by herpes zoster), and chickenpox. This medication is also used to treat outbreaks of genital herpes. In people with frequent outbreaks, Activir is used to help reduce the number of future episodes. Activir is an antiviral drug. However, it is not a cure for these infections. The viruses that cause these infections continue to live in the body even between outbreaks. Activir decreases the severity and length of these outbreaks. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. In addition, in people with a weakened immune system, Activir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

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In blood samples obtained 24 h after the episode, the serum betalipoproteins from male normotensive patients showed a high tendency to precipitate when incubated with the intima-media extracts, nearly twice the value measured in the control group. Metallo-beta-lactamases (MbetaLs) are zinc-dependent enzymes able to hydrolyze and inactivate most beta-lactam antibiotics.

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A complex balance of signaling factors and surface proteins are expressed and regulated in a temporospatial manner that promote keratinocyte motility and survival to activate wound re-epithelialization. We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. Additional questions concern the immune mechanisms involved in protection and the risk of eliciting adverse reactions in the central nervous system of treated patients. The male:female ratio was 48:19, with a mean age of 67 years (range, 42-85 years). Both women were treated with substitution therapy using locally-prepared cryoprecipitate.

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In Experiment 1, increasing the ratio requirement on Button B decreased the number of ratios completed in 4 of 5 subjects. We examined the role of fibronectin (FN) and FN-binding integrins in macrophage differentiation. The molecular mechanisms underlying the apoptogenic effect of p66Shc are unknown.

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As only two-thirds of patients with this rare disease present with elevated hormone levels, new markers deserve further investigation to offer more specific, individualised tumour monitoring. In the adult human, the kidney is the main organ for the production and release of erythropoietin (EPO).

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Some forms of olfactory learning require intact noradrenergic terminals in the olfactory bulb that originate from the locus coeruleus. Polymerase chain reaction (PCR) for detection of BLV provirus-- a practical complement for BLV diagnosis? We report the first prenatal diagnosis with a discordant result in a dizygotic pregnancy. These cases may represent a hereditary brain malformation with a distinct pattern of abnormal cortical gyration.

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Periocular corticosteroids shortened the duration of diabetic papillopathy from a reported median of 5 months to 3 weeks in the present uncontrolled observational study, partly by their angiostatic and antioedema effects at the level of the anterior optic nerve. Because heat-related deaths are preventable, community-wide response to heat emergencies, together with individual and community education programs, could greatly decrease morbidity and mortality. Based on our findings, we suggest that allopregnanolone may mediate the effects of progesterone in promoting cognitive and morphological recovery from TBI through, among others, its direct or indirect effects on GABA-modulated neurons in the MDN and the NBM.

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Furthermore, saratin specifically inhibited the binding of the alpha2 integrin subunit I domain to collagen, and prevented platelet adhesion to collagen under flow to the same extent as observed in the presence of a combination of mAbs to glycoprotein Ib and alpha2beta1. Trypan blue was perfused into the scala tympani of anesthetized mice to stain the basilar membrane. The decision for an abortion should not be influenced by a possible usage of the tissue, as is stated in the guidelines of the german medical council for the use of fetal cells and tissue as well as in the guidelines from NECTAR. Polyarthritis, rash and lymphadenopathy: case reports of two patients with angioimmunoblastic lymphadenopathy presenting to a rheumatology clinic. An anonymous postal questionnaire seeking both quantitative and qualitative data was sent to 138 registrars during June 1993.

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Granule cell development in the cerebellum is punctuated by changes in Sox gene expression. Left ventricular mass in 169 healthy children and young adults assessed by three-dimensional echocardiography. Do not eat the red food!: prohibition of snacks leads to their relatively higher consumption in children. Partial resection of the large colon for the treatment of stenosis associated with verminous colitis in a horse. Therefore ASIC2 and 3 are targets for benzamil to inhibit colonic afferent mechanosensitivity.

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In contrast to its two-dimensional version, for reasonable values of the interaction parameters the resulting phase diagram resembles that observed experimentally for 3He-4He mixtures, for which phase separation occurs as a consequence of the superfluid transition. The rates of decrease in IL-4 and specific IgE at 3 and 6 months were significantly greater in the patients treated with suplatast tosilate and immunotherapy than in those treated with immunotherapy alone. The model must incorporate the laws of fluid dynamics, the nucleation and condensation process, and has to predict the size distribution of the particles created (PSD) at every position along the nozzle axis.

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Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3). For most categories, there was considerable variability in the number of repetitions observed.

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Other effects, mostly observed at 13 weeks, included decreased responsiveness to a visual stimulus and mild tremors. The physiopathological mechanisms implied in the syndrome and currently recognized, are also the object of this 1st part. The Primary Health Care Guide to UK Parasitic Diseases is aimed at health professionals working in primary care and offers an easy reference and practical advice on prevention, recognition and management of parasitic disease. During the second step, the preincubated cells were injected intravenously into P1xP2 F1 irradiated hybrids and the in vivo mixed lymphocyte reaction assessed by 3H-thymidine uptake by the cells harboured in the spleen of the host.

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These differences are expressed more clearly in the presence of 480 muM dThdMP during inactivation. Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes. The antigen binding properties, determined by ELISA and BIAcore measurements, were not affected by removal of the disulfide bonds. The morphological changes of PMNs treated with or without ONO-AE-248 were observed by electron microscope, fluorescence microscope and confocal microscope. Renal functional reserve tests were performed in all patients before the operation, at postoperative day 9, and at 6 months after operation.

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Role of aldose reductase inhibitors in the development of peripheral neuropathy in experimental diabetes The Cdc14 protein encodes a dual-specificity protein phosphatase which functions in late mitosis, and considerable genetic evidence suggests a role in DNA replication.

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A recently adopted classification system for these lesions distinguishes between three grades of pancreatic intraepithelial neoplasia (PanIN). Dwee1 kinase is closely related to human and Xenopus Wee1 homologues, and can inhibit Cdc2 activity by phosphorylating a critical tyrosine residue.

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Hamster lung cancer model of carcinogenesis and chemoprevention. The major organic causes of dyspepsia are chronic peptic ulcer disease, gastro-oesophageal reflux disease and malignancy.

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Tumor cells were necrotic or filled with lipid vacuoles regardless of the distance from nearby vessels. After treatment, skin color and texture were more homogeneous with a decrease in the unwanted melanocytic pigmentation. The axonal signal that initiates myelin breakdown during Wallerian degeneration induces multiple MTOCs and MT bundles in Schwann cell perinuclear cytoplasm and in cytoplasm between degenerating myelin ovoids. Moreover, the localization of these three constituents in the secretory granules also suggests that, in the rat anterior pituitary, they follow the regulated secretory pathway.

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The analysis of ductal type and lobular type microcalcifications is more challenging. In comparison with our previous study, the pathological changes in the brain appeared at the same mercury exposure dose as the glomerulonephritis. Synovial fluid and serum concentrations of aminoterminal propeptide of type III procollagen in healthy volunteers and patients with joint disease.

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The degradation process of mitochondria in rabbit reticulocytes proceeds predominately directly in the cytosol rather than in secondary lysosomes as judged by electronmicroscopy. The three-dimensional positions of these residues match those of corresponding histidines at the active center of human PCD. The average torque values of the concentric phases in the SSC movement were significantly higher than the torque values for pure concentric actions in all four groups and at both velocities. A case of tuberculosis with multiple stenosing lesions of the small intestine Amino acid requirement of growing pigs depending on amino acid efficiency and level of protein deposition 1st communication: lysine.

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Our data suggest that LFS of the cPC may be an effective method of inhibiting kindled seizures by preventing both afterdischarge generation and propagation. A mathematical model that characterizes the response of venous oxygenation to changes in cerebral blood flow (rCBF) and oxygen consumption has been previously presented. Stability of the treatment result was excellent in the 3-year 9-month follow-up at the age of 18. This community based prospective cohort study of 656 families in three adjacent counties in the Piedmont region of North Carolina characterizes the patterns and rates of injuries among children less than 5 years of age in three child care settings, home care (HC), center based care (CBC), and other out-of-home care (OOHC).

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An observational study in which urinary pyridinium crosslinks of collagen were measured in fasting first void urine samples over five consecutive days. Haemodynamics during remifentanil induction by high plasma or effect-site target controlled infusion. Eighteen of 24 sera obtained before vaccination were found to be seronegative by complement fixation and neutralization tests. Paracetamol permeates readily into the cerebrospinal fluid of children. The question was addressed as to whether collagenase may act as an activator or a target in the antiproliferative mechanism of MHP.

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Neither arteriovenous crossing defects nor microaneurysms were seen. Renal transplant recipients without herpes zoster served as controls. Lymphoscintigraphy has been used since the early 1960s to demonstrate lymphatic drainage of head and neck tumors, but did not prove satisfactory. Inhibition of thrombin-catalyzed factor V activation by bothrojaracin. Physical functioning was assessed using the 10-item scale from the Short Form 36 Health Survey, with a score in the lowest quartile indicating poor physical functioning.

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Self-reported HT could screen one-half of the participants for confirmative HT and was significantly associated with CVD mortality. The results showed that DE at all exposure levels suppressed the proliferative response of T cells.

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An interferon-like substance was detected in the blood stream 20-40 hours after the intraperitoneal injection of carbopol. The pharmacological stress test induced changes in ventricular dimensions at heart rates of 80 to 140 beats/min. The deduced amino acid sequences disclosed that at the peptide position 45, Ser is dominant in non-cancerous lesions, and Gly in cancerous lesions, respectively.

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Ruptured pancreaticoduodenal artery pseudoaneurysm with chronic pancreatitis presenting as recurrent upper gastrointestinal bleeding. We found that for a given geometry, the ratio of the alveolar flow (QA) to the ductal flow (QD) played a major role in determining the flow pattern. Because FA proteins function within an extended network of proteins, some of which are still unknown, we recently established cell-free assays in Xenopus laevis egg extracts to deconstruct the FA pathway in a fully replication-competent context. Pulmonary vascular impedance response to hypoxia in dogs and minipigs: effects of inhaled nitric oxide. Charts of eyes with high myopia who had LASIK surgery by the same surgeon between 1994 and 2000 were reviewed in 2003, and patients were given an appointment for follow-up examinations.

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A total of 45 relevant patients were exposed to electromagnetic field of ultrahigh frequency (460 MHz). Occurrence of nutrition-associated complications was documented for 30 d postoperatively.

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Relationship between heavy fuel oil phytotoxicity and polycyclic aromatic hydrocarbon contamination in Salicornia fragilis. Later in life, catch-up growth cannot be induced by nutritional intervention or dialysis and renal transplantation allows catch-up growth in only a small percentage of patients. The authors report 5 cases of pseudotumoral tuberculosis of the liver. The nodules are incubated in medium 199 containing 1-5 mg collagenase and 0.2 mg gentamicin per ml for 6-48 hours in a waterbath at 30-37 degrees C.

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The resulting polytides provide a promising strategy for transforming disulfide-rich peptides into therapeutics. The Ad Hoc Committee on Cardiac Surgery Credentialing of The Society of Thoracic Surgeons. A new, extended-release formulation of alprazolam now allows for once-daily rather than t.i.d. From the overall similarity of the optical properties of apoLDL1 and apoLDL2, we conclude that the secondary structures of apoLDL1 and apoLDL2 are identical.

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The presented data shows that the internationally prevalent medical practice of prescribing anti-psychotics for non-psychotic indications is not only ethical and legal, but also an essential treatment modality in the field of dermatology. This study aimed to assess the association between implementation of the Guidelines and the outcome of TBI patients. In some individuals, recording sensory nerve action potential (SNAP) and as a result NCV is impossible.

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The present study concerns the question: Are retroposons created in meiotic and haploid spermatogenic cells? No breeding site was found in the small tributaries of the Sanaga and Mbam Rivers, and the dispersal of S.

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Asymptomatic patients with moyamoya disease should be carefully followed-up to further clarify their outcome and to establish the management guideline for them. Although these results fail to support prior findings of independent associations of these polymorphisms with smoking status, our exploratory findings suggestive of gene-gene and gene-treatment interactions warrants further investigation.

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Antigen fluctuation and virus activation in EL 4 cells transplanted in hybrid mice or cultured in vitro. The availability and utility of cell lines with limited and continuous doubling potential are summarized and documented. Nonspiking interneurons that contribute to interjoint coordination. Polychlorinated biphenyls (PCBs) are widespread, low-level environmental pollutants associated with adverse health effects such as immune suppression and teratogenicity. International veterinary nurses and technicians association world congress - England 1993.

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Master-equation approach to collisionally induced absorption and emission. Fluorescence from a pH-insensitive conjugate of folic acid, folate Texas red (FTR), was readily observed on the apical surface of the proximal tubules and in multiple cellular compartments, but little binding or uptake could be detected in any other kidney cells. These results are discussed in relation to the hormone changes occurring during normal delivery.

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Non-steroidal anti-inflammatory drugs decrease the quality of pleurodesis after mechanical pleural abrasion. The direct demonstration of structural alteration of this protein provides strong evidence for structural gene mutation in this cultured cell system. Torsion of a cryptorchidid testicle presents a non-specific symptomatology. Genetic testing is necessary for definite diagnosis in some cases especially in the young generation.

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DDE strongly inhibits cell growth and affects cell viability without any differentiating effects. Secondly, the influence of the abduction angle of the cup on measurement accuracy was investigated. Considerable progress has been made during the past decade in the development of mechanistic models that allow complex chemical, physical, and biological processes to be evaluated in the global change context.

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While numerous studies have established the essential nature of p63 in the epidermis, the basis of this requirement, and the unique, as well as, overlapping functions of the individual isoforms, remain controversial. We observed that a mutation affecting a tRNA processing function significantly affected the emergence of such mutants, suggesting that C58 contained a positively acting gene conferring resistance to tetracycline. These results clearly suggest that NK cell activation in vivo by the protein bound polysaccharide PSK abrogates metastasis formation in mice. Western blot analysis showed a reduced amount of beta-glucocerebrosidase-related polypeptides in fibroblasts.

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PBB homologs in sera of Michigan dairy farmers and Michigan chemical workers. ETV6-NTRK expression leads to the constitutive activation of two major effector pathways of wild-type NTRK3, namely, the Ras-mitogen-activated protein kinase (MAPK) mitogenic pathway and the phosphoinositide-3-kinase (PI3K)-Akt pathway mediating cell survival, and both are required for EN transformation.

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Vaso-vagal reactions during femoral arterial sheath removal after percutaneous coronary intervention and impact on cardiac events. To assess tooth whiteness clinically using an image analysis system and a whiteness algorithm to compare with visual shade matching. After failing medical therapy, stenting of an extensive segment of the right coronary artery has been clinically successful after 24-months follow-up.

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Sulfated polysaccharides and a synthetic sulfated polymer are potent inhibitors of Chlamydia trachomatis infectivity in vitro but lack protective efficacy in an in vivo murine model of chlamydial genital tract infection. Significant public health benefits will result from greater use of thrombolytic therapy in acute myocardial infarction. Occupational allergic contact dermatitis from ethyl chloro oximido acetate. Here we describe the effects of cartilage-specific inactivation of the Rac1 gene in mice. Report on a meeting organized by the BIR Nuclear Medicine Committee and the IPEM Radionuclide Special Interest Group, held at the British Institute of Radiology, London, 11 February 1997.

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Mechanism of a plastic phenotypic response: predator-induced shell thickening in the intertidal gastropod Littorina obtusata. Over the next 8 years, both girls and boys who met criteria for ADHD in Year 1 exhibited more ADHD symptoms and impairment than same-sex comparison children. The design of synthetic polymers may affect structural features of inflammatory cells, for example the expression of endogenous sugar receptor molecules like lectins in macrophages and foreign body giant multinucleate cells. AK inhibitors have been shown to provide effective antinociceptive, antiinflammatory and anticonvulsant activity in animal models, thus suggesting their potential therapeutic utility for pain, inflammation, epilepsy and possibly other central and peripheral nervous system diseases associated with cellular trauma and inflammation.