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Bridging studies are late phase I safety/tolerance studies that determine the maximum tolerated dose (MTD) in patients before phase II efficacy studies are initiated, facilitating the transition from phase I to phase II development. The chronic constriction injury (CCI) model described by Bennett and Xie has been thought to show similar painful conditions to those seen in CRPS patients.
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Co-administered Delta 9-THC and CP 55,940, but not SR 141716, partly prevented the long-term 5-HT and 5-HIAA depletion caused by MDMA in various brain regions. Resistant strains were isolated from both HSV type 1 and HSV type 2. Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells. Cytomegaloviruses are known to encode several gene products that function to subvert MHC-dependent immune recognition. Depot leuprolide is an effective alternative to danazol in decreasing the extent of endometriosis and endometriosis-related pain.
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