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In addition, the effects of the paraoxonase1 polymorphisms on lipid and paraoxonase1 responses to fenofibrate therapy were examined. The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin.

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The precise role of any of these factors in thrombosis or bleeding remains speculative. The exponentially growing interest in therapeutic strategies targeting hypoxia/HIF will undoubtedly generate more active compounds for preclinical and clinical development. Immunomodulatory effects of macrolide antibiotics in respiratory disease: therapeutic implications for asthma and cystic fibrosis. In the present study, we found that exposure to zinc results in necrosis of prostate carcinoma cells. The scope of the method is illustrated by fitting models to several real data sets and assessing each model using goodness-of-fit techniques.

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The limited disruption of the extensor mechanism improves the rapid restoration of quadriceps muscle control. The keratin K8 and K19 reactivity was retained in those chordomas showing solid sheets of epithelioid, spindle cells, or cartilaginous metaplasia, and in one of two cases showing overtly sarcomatous transformation. Linking primary care with psychiatric care has long been promoted as a way to improve access to rural mental health services.

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The level of sex steroid receptors in the myometrium during cesarean section Fibrillin influence on plastid ultrastructure and pigment content in tomato fruit. We have investigated the receptor-mediated binding and uptake of low-density lipoprotein (LDL) and its insoluble complex with dextran sulfate to determine the contribution of positively charged sites in LDL to receptor-mediated interactions.

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In study II, eight male and eight female smokers received 0, 15, and 30 micrograms/kg nicotine intermittently and were allowed to smoke their preferred brands of cigarettes ad libitum. The hybrid capture human papillomavirus (HPV) DNA assay is offered by the manufacturer to assist clinicians with patients with ASCUS pap smear results to assess the risk factor and to potentially direct follow-up of these patients. Intermediate results of Weber and our own data show promising outlook for a solution to the wear-induced problem in hip replacement. Age-related changes in neuronal nicotinic acetylcholine receptor subunit alpha4 expression are modified by long-term nicotine administration.

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The high incidence of reduced antibiotic susceptibility among gram-negative bacteria in these ICUs suggests that more effective strategies are needed to control the selection and spread of resistant organisms. This is why we used double isotope scintigraphies with 67Ga citrate and 99mTc sulfur colloid, with digital subtraction, after simultaneous recording of 99mTc and 67Ga data on magnetic tape by means of an interface. CFH Y402H was inversely associated with CHD among women, but not men. Immunosuppression, however, continues as a significant clinical problem. Effect of dietary cyclopropene fatty acids on the octadecenoates of individual lipid classes of rat liver and hepatoma.

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However, in the selected studies where sonic brushes were tested in orthodontic and dental implant patients there was a more significant decrease in the indices. The utilization of alanine for glucose synthesis in vitro was similar for both lean and obese rats, but its utilization for fatty acid synthesis was higher in the obese rat. There is debate about the role of crude mortality rates and case-mix adjusted mortality rates in monitoring the outcomes of treatment. Alkaline phosphatase activity presents a twofold increase in the controls and stimulated explants.

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For POPE, three temperature ranges were identified, in which the lower one (270-280 K) was associated with a pre-transition state and the higher (290-300 K) with the post-transition state. Enzymic characteristics and effects of testosterone treatment on nucleolar and chromatin-associated histone phosphokinase activity of rat ventral prostate.

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Four electronic databases were searched for controlled clinical trials of antifungal herbal medicines. Comparison of the binding properties of two 6 beta-amidinopenicillanic acid derivatives that differ in their physiological effects on Escherichia coli. GnRH neurons were immunostained but were very faintly labeled with biocytin injected into the spinal cord. Based on these results it is shown that the obtained surfaces are, in contrast to surfaces prepared under UHV conditions, stabilised by the adsorption of a monolayer of hydroxides.

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Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. Radiographic evaluation led to early diagnosis and treatment of spinal cord compression from metastatic prostate adenocarcinoma. Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Angiogenic activity in BALF from 12 healthy, nonatopic subjects and 10 atopic subjects with mild asthma was evaluated by examining tubule formation at 11 days in cocultures of human endothelial cells with dermal fibroblasts. Robotic technology is preferable to conventional laparoscopic instrumentation for the surgical treatment of gynecologic malignancies and most operations for benign disease of certain complexity such as hysterectomy myomectomy, and invasive pelvic endometriosis.

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In the light of our results, the response mechanism of the electrode is discussed and HMoO(2)(O(2))(2)(-) is suggested as the response ion. Introduction to supplemental issue: research issues in suicide and sexual orientation. The cytokines IFN-gamma and TNF have contributory roles in host defense against P. We cloned the chicken Hoxb-4 gene and performed in situ analysis to investigate conservation in patterns of expression between the chicken and mouse. Intraoperatively the lesions appeared as 0.3 cm red-black nodules and, microscopically, consisted of degenerating chorionic villi associated with implantation changes in the surrounding tissue.

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These oysters were imported after careful examination, and were maintained in laboratory quarantine. To examine survival rates for paediatric trauma patients requiring cardiopulmonary resuscitation (CPR) in the pre-hospital setting, and to identify characteristics that may be associated with survival.

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Electron correlations in the L-shell photoionization of heavy elements. Some of these devices have been demonstrated to reduce anaesthesia drug consumption and hasten recovery in older children. Specifically, dopamine response to an acute amphetamine challenge was assessed in striatal subregions in cocaine-dependent and healthy comparison participants using positron emission tomography (PET).

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Since no medical or technological solution to the problem is near at hand and given the fact that the HIV virus is heavily reliant on human sexual behaviours for transmission, tackling the problem of AIDS rests on addressing change of sexual behaviour. Nitric oxide compartments in the mushroom bodies of the locust brain. Extension of beef cattle genetic evaluation procedures to multibreed data sets is proposed as a way to allow inclusion of crossbred animals into current analyses and to provide comparisons between purebred animals of different breeds.

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5 cases of an association of Klippel-Trenaunay-Weber syndrome and of spinal cord angiomas are reported amongst a series of 150 cases of malformation of the cord. Setting specific goals, making sure the entire staff is committed to achieving them, and understanding that the process is long-term are the first steps in becoming a high-performing hospital. aureus bacteraemia and they have a four times higher mortality from central venous catheter-related S. The case-study illustrates that the different demands and desires which are demanded from prosthesis and aids, are related to the age and developmental level of the child. All isolates induced interferon-gamma and interleukin-10, whereas interleukin-4 and interleukin-2 titers were low to undetectable.

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Corneal thickness changes during herpes simplex virus disciform keratitis. Infective endocarditis complicated with thalamic infarction and mycotic aneurysm rupture: a case report.

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Gestational age in Canada was based on the clinical estimate, whereas in the United States both menstrual-based and clinical estimates were used. In addition, we have developed a fast C3 purification method by engineering a 6XHIS tag into the C3a portion of the molecule, thereby avoiding the need for subsequent separation of the tag from active C3b molecules.

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The aim of this study was to shorten the Health-Related Quality of Life (HRQL) DISABKIDS Chronic Generic Measure (DCGM) for children and adolescents and to test its reliability, construct, and external validity. Interstitial fluid pressure in cervical carcinoma: within tumor heterogeneity, and relation to oxygen tension.

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This study could not rule out a possible association between non-right handedness among boys and ultrasound exposure in early fetal life. Cytokines with their inflammatory as well as their regulatory activities may play a role in the perpetuation and possibly the initiation of inflammation in this disease and its local and/or systemic complications. By CE of neuraminidase-treated rFVIIa a faster-moving double peak is observed. The profile of the enzymatic activity is explained by the uniqueness of the lipid molecules arrangement at the phase transition.

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With the influence of stimulus complexity controlled, pictures of objects were chosen that varied in the number of intensity changes in the high-frequency components, with those of the low-frequency components kept constant. The inhibitory effects by anthracycline compounds appear to be relatively specific for viral polymerases. PTX partially reversed TNF-alpha-but not TPA-mediated inhibition of SP-A and SP-B mRNAs without altering NF-kappa B binding. Obstructive sleep apnoea syndrome (OSAS) is a significant public health problem. Primary torsion of the omentum: preoperative diagnosis with abdominal ultrasonography

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Impaired cough secondary to weakness from neuromuscular disease (NMD) can cause serious respiratory complications, including atelectasis, pneumonia, small airway obstruction, and acidosis. Coumarin-caged glycine that can be photolyzed within 3 microseconds by visible light. Using a population genetics approach and microsatellite markers, we analysed genetic diversity of this fungus at each level of genome organisation. Treatment of Raji-bearing SCID mice with IMMU-106 yielded median survival increases of up to 4.2-fold compared with control mice.

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Acute toxicity tests using Phyllospora comosa (Labillardiere) C. To distinguish between these possibilities we have used a permeabilized cell system supplemented with phospholipid-modifying enzymes that generate either DAG or PA. Sex differences in ACTH pulsatility following metyrapone blockade in patients with major depression. The properties of N,N-dialkyl chitosan monolayers and corresponding vesicles have been studied by LB technique and drug-release experiment. Kinetic analyses of these reactions yielded Km values of 0.2 microM for alpha chain cleavage and 0.26 microM for beta chain cleavage, as well as kcat/KM values of 7 x 10(5) and 4.6 x 10(5) M-1 s-1 for alpha and beta chain reactions, respectively.

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We decided to evaluate published evidence in relation to epidemiology, clinical features and course, laboratory diagnosis, treatment and outcome of human H5N1 influenza, and develop institutional clinical management guidelines. c-Kit proto-oncogene is more likely to lose expression in differentiated thyroid carcinoma than three thyroid-specific genes: thyroid peroxidase, thyroglobulin, and thyroid stimulating hormone receptor. In some cases, however, 67Ga citrate is less concentrated in neoplasic tissue, and it is not possible to detect a tumoral lesion in a cirrhotic liver.

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Branched tubes can use this radial concentration distribution to concentrate dilute suspensions. The Versajet Hydrosurgery System utilizes a reusable power console with foot pedal activation, disposable handpiece and tubing assembly in conjunction with sterile saline and standard waste receptacle.

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Importantly, when corrected for brain size, three of the five callosal regions were still smaller in the alcohol-exposed children, although overall area of the corpus callosum was no longer significantly different. However salicylate had no obvious effect on ROS release in DCFDA assay. In situ staining of beta-galactosidase activity found high expression in metulae, phialides, and conidia during conidiophore development, indicating that the expression of chiA is developmentally regulated. Injury to the skin initiates a complex process of events involving inflammation as well as the formation and remodeling of new tissue. When the 5-HT3 antagonist, ondansetron, was perfused through the microdialysis fiber, not only was the background activity of the cell increased, but also the responses to BRUSH, PRESS and PINCH stimuli.

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Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells. In 1996 and 1997, 153 eyes of 110 patients with various corneal conditions were examined. We conclude that JP do not express p53 gene and aneuploidy but had higher activity of ODC and TyK enzymes, suggesting a higher stage of cell proliferation. All OHCA-calls where the Copenhagen Mobile Emergency Care Unit (MECU) was involved from 1994 to1998 are included in this study.

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36 patients who received a TMF over a 6.5 year period for serial assessment of the oral healing, 24 patients whose scars over the reconstructed area were assessed clinically, and 11 whose repaired mucosa was assessed histologically. Our recent studies demonstrate that thrombin is an important mediator of neutrophil-dependent injury in ischemia-reperfusion injury. This case may contribute to the existing knowledge regarding use of atypical antipsychotics in pregnancy. Inguinal mass due to an external supravesical hernia and acute abdomen due to an internal supravesical hernia: a case report and review of the literature. This protocol is poorly tolerated by elderly patients or those with poor performance status, and 350 mg/m2/day is our recommended dose for 5FU as given in this protocol.

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Extrapolated from the Medical Therapy of Prostatic Symptoms (MTOPS) study, not yet fully published, again raises the question of the effectiveness of such a combination. Exposure to non-inherited maternal antigens (NIMA) has life-long immunological consequences that may result in tolerance or immunity to these antigens. Extrinsic photoconduction and Rydberg states due to a methyl iodide impurity in xenon. The administration of Apranax 550 or Voltaren 50 within the period of 10 days after the operation decreased significantly the incidence of inflammatory reactions.

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The use of trace deposits for establishing the weapon of an injury Although cognitive decline may not be associated with greater frequency of incontinence, women with cognitive decline may have more difficulty coping with incontinence symptoms. Highly ordered nanostructured surfaces obtained with silica-filled diblock-copolymer micelles as templates. Eighty-six patients in whom both HSG and laparoscopy were performed were included in the study.

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The aim of this study was to compare the outcome of consecutive patients with abdominal aortic aneurysm (AAA) treated concurrently by open operation and endoluminal intervention by the same surgeons during a defined interval. Elevated serum beta-HCG (30.3 mIU/mL) and new pulmonary lesions were noted by computed tomography 4 months after completion of EMACO. Guanine nucleotides inhibit NMDA and kainate-induced neurotoxicity in cultured rat hippocampal and neocortical neurons. Latissimus dorsi muscle and its short perforator-based skin compound free flap. Calcium supplementation is associated with endothelium dependent attenuation of vascular smooth muscle reactivity in normotensive pregnant and nonpregnant rats.

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Identification of phosphorylated proteins from thrombin-activated human platelets isolated by two-dimensional gel electrophoresis by electrospray ionization-tandem mass spectrometry (ESI-MS/MS) and liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS). Daily exposure of DEXA at zeitgeber time 0 (lights on) or at zeitgeber time 18 (6 h after lights off) for 6 d caused a phase advance or phase delay of bioluminescence rhythm in the lungs, respectively, similar to light-induced phase shifts in locomotor activity rhythm. Changes of pituitary thyrotropin releasing hormone (TRH) receptor level and prolactin response to TRH during the rat estrous cycle.

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Glucose was found to increase the activity of the guanine nucleotide-exchange factor eIF-2B over a rapid time course (within 15 min) and over the same range of glucose concentrations as those that stimulate insulin synthesis (3-20 mM). Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx.

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It has been recognized that the conventional methodologies are a limitation to further vaccine development. The external validity of the RPA-derived classification system was assessed, and its ability to stage patients and to predict locoregional control of the disease was compared with the TNM system. The results show that neither a direct statement is possible nor can a logical conclusion by indirect analogy be made. The collision energy chosen for the multiple reaction monitoring (MRM) experiment was optimised. Most of the 64 descriptors used for the development were extracted from semiempirical and density functional theory (DFT) founded calculations.

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Only one-third of patients, however, initially respond to trastuzumab monotherapy and the majority of initial responders demonstrate disease progression within 1 year of treatment initiation. The levels of cytokines and tumor markers were higher in patients with a more advanced tumor stage. The apoptosis-inducing abilities of CEP1612 and its analogous compounds match precisely their order for inhibition of the proteasome chymotrypsin-like activity.

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Although pentraxin structures have not been verified, the isolated proteins all appear to be pentraxin-like based on their binding specificity, molecular weight of subunits, cross-reactivity with antibodies to human pentraxins and N-terminal amino acid sequences. Flexible intramedullary nailing for a segmental radial fracture of the neck and shaft in a child. The OAD technique had a high degree of acceptance among the treated patients, however, some details as the interference of the activation rod continue to disturb them.

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Studying the rate of absorption and synthesis has come only recently into the foreground of interest. All three neonates in these cases underwent surgical treatment and ventriculoperitoneal (VP) shunt insertion for associated hydrocephalus. We report here the cloning of the human and murine JAGGED2 (JAG2), a Serrate-like gene, and the analysis of its expression pattern during embryogenesis. Her symptoms were first misdiagnosed as allergic conjunctivitis at a local medical clinic. We have prepared, in a single synthesis, a cocktail of peptides we have designated a hypervariable epitope construct (HEC), which collectively represents much of the in vivo variability seen in an epitope.

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Although physiotherapy (PT) plays an important role in improving activities of daily living (ADL functioning) and discharge rates, it is unclear how many nursing home residents receive treatment. Results of this investigation suggest that SSc patients with ACA positivity, after a primary fibrogenetic noxa, react with a more abundant release of MMP/TIMP, whereas patients with anti-Scl70 antibody show a normal response. The study implies that oxidative stress and apoptosis contribute to PN-associated hepatic dysfunction. The purpose of this investigation was to clarify a possible link between dissociation and kleptomania, a disabling disorder whose phenomenology remains understudied.

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Results showed that across all speakers and listeners, the AV presentation mode resulted in significantly higher intelligibility scores than the AO mode. Targeting of porcine pancreatic phospholipase A2 to human platelets: introduction of an RGD sequence by genetic engineering. The mention of the birth stool is a marginal issue in medical as well as non-medical texts. The number of TRAP-positive osteoclasts was counted, and the relative hyalinized area was measured on the pressure side of periodontal ligament.

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Double-blind, placebo-controlled comparison of the safety and efficacy of orally administered etodolac and nabumetone in patients with active osteoarthritis of the knee. Thermodynamic characterization of the protein-protein interaction in the heteromeric Bacillus subtilis pyridoxalphosphate synthase. It is therefore concluded that mean transit time though it theoretically offers the attractive advantage of being a sensitive indicator of both large and small airways obstruction, is unlikely to play a major part in the routine evaluation of lung function in asthmatic children. A select group of fourth-year medical students provides a successful alternative to faculty in the teaching of the physical examination to first-year students.