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Most methods for predicting functional sites in protein 3D structures, rely on information on related proteins and cannot be applied to proteins with no known relatives. If symptoms occur again, histology is recommended to exclude vasculitis. Total global ischemia leads to prolonged attenuated dilator responses of cerebral arterioles to CGRP. Diverse effects of Stat1 on the regulation of hsp90alpha gene under heat shock.

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There has been no systematic study of the immune response of individuals aged over 60 years living in Schistosomiasis mansoni-endemic areas, although senescence is reportedly associated with susceptibility to infection and progressive decline in immune function. Given that pentoxifylline has potential therapeutic value in blocking the effects of Vpr in HIV-infected patients, understanding the molecular mechanisms by which pentoxifylline antagonizes Vpr may have general implications for HIV therapy.

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Recent studies indicate that chronic exercise may directly improve endothelial function, thus providing an additional explanation for the benefits of increased physical activity. We have studied the molecular mechanisms involved in yolk formation in a reptilian species Podarcis sicula, a lizard characterized by a seasonal reproductive cycle. MHC class I tetramers are powerful tools for the detection of T cell receptor-MHC class I interactions, and have recently been used to evaluate KIR-MHC class I binding ex vivo. These results suggest that eNOS expression is up-regulated in the endothelium via PI-3K pathways after transient forebrain ischemia, and that preconditioning-induced eNOS expression plays an important role in neuroprotection in the ischemic tolerance. Anti-apoptotic effects of curcumin on photosensitized human epidermal carcinoma A431 cells.

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To establish structure-activity relationships, derivatives of a recently described sulfur-containing antitumoral platinum complex, bis(O-ethyldithiocarbonato)platinum(II), named thioplatin, were analyzed. The animals were divided into four groups: sham operated, CLP, basic support (saline plus antibiotics), basic support plus N-acetylcysteine, and deferoxamine. The responses of two of the non-responders were similar to those in DOC excess hypertensives who showed reduced responses of aldosterone to some of these stimulations. The point-spread function (PSF) was measured when a target mirror was immersed in either water or lipid.

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The three weeks of terror created by the snipers from October 2 to October 22 affected Maryland psychiatrists as it affected other Maryland citizens. This study was undertaken to compare the efficacy of a novel synthetic material (TMS-1) with polytetrafluoroethylene, polypropylene, and primary closure of experimentally fashioned clean and contaminated abdominal wounds. It is also more economical than a regime of intravenous cefuroxime and does not require nursing staff with training in intravenous techniques.

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The primary endpoint accepted for analysis was the hospital case fatality rate (HCFR). With typical subjects, the long-term coefficients of variation were about twice the short-term. Moreover, in the different stages of diastolic dysfunction, due to the interference of the co-varying relaxation, the increase in E/v(p) is more pronounced.

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In the case of FeP, the relatively large substituents of the phosphorus atom are reorganized during aging, providing a structural support of an aging reaction that proceeds through a nucleophilic attack on the phosphorus atom. Carboxypeptidase E (CPE) deficiency in mice with the fat mutation have reduced stomach function.

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Quantitative analysis of minimal residual disease predicts relapse in children with B-lineage acute lymphoblastic leukemia in DFCI ALL Consortium Protocol 95-01. Momordica charantia, locally known as Ampalaya, is being widely used and advertised for its hypoglycemic effects. Comparison of cyclic nucleotide and energy metabolism of intact mouse retina in situ and in vitro. In vivo, we found a therapeutic window in which autocrine/paracrine HGF made tumors sensitive to low doses of the drugs, which were ineffective on their own. The isoforms have a common C2H2 zinc-finger domain but different N-termini that include potential effector domains.

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The territorial origins and attitudes toward death in the Havana squadron, 1780-83 Hence, the use of specific observational analysis, three-dimensional kinematic recordings, poly-electromyography and electro goniometry for the analysis of gait, the use of force plate for the analysis of postural stability and the use of electromyography and multiaxial accelerometers or gyroscopes for the analysis of movement disorders. Central nervous system malformations and early end-stage renal disease in oro-facio-digital syndrome type I: a review.

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The rapid induction of response, high response rate, unmaintained complete remissions of long duration and relatively low rate of toxicity may justify the use of this combination for the treatment of small skin tumors when other treatment options are of no avail. While studies of trophic hormones are ongoing, the most reliable current method to facilitate adaptation is to provide enteral nutrition. This was demonstrated by double-label immunohistochemistry, using combinations of antisera against S-100, vimentin and beta-endorphin, and in situ hybridization histochemistry for POMC mRNA combined with immunohistochemistry for S-100.

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Against the motion: open partial nephrectomy is the standard of care for small resectable solid renal masses. Northern blot analyses probing for fibronectin, transin, TIMP-1 and TGF-beta 1 were carried out on RNA extracted from mesangial cells exposed to individual and combinations of cytokines. High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans.

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ATP content and biomass activity in sequential anaerobic/aerobic reactors. Lactate measured in diluted and undiluted whole blood and plasma: comparison of methods and effect of hematocrit. Therefore, DNA analysis can be a powerful tool to supplement conventional scene reconstruction in cases of deaths due to electricity.

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To assess silencing efficacy of RNA prepared in vitro, transcription and cis cleavage reactions were carried out to prepare defined single-unit ribozymes. Procaine treatment that blocked the conduction of vagal afferent C wave did not significantly alter the response of brief tachypnea to ammonia. Appearance of defective simian virus 40 following infection of cultured human glioblastoma cells. It is suggested that the depressive effects of immunotherapy in humans likewise reflects the synergistic actions of the cytokine and the ongoing distress experienced by patients.

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Postoperative topical mitomycin C in conjunctival squamous cell neoplasia. Messenger RNA hybridization revealed an individual expression pattern for each analyzed growth factor. Consistent with this, the viral protein inhibited the UV-induced activation of the proapoptotic Bcl-2 family members Bax and Bak.

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Human dendritic cells, pulsed with either melanoma tumor cell lysates or the gp100 peptide(280-288), induce pairs of T-cell cultures with similar phenotype and lytic activity. In acetic acid-induced gastric lesions, repeated oral administration of DA-6034 exhibited a U-shape activity in ulcer healing, with the maximum and minimum inhibition being observed at 30 and 10 mg/kg/day, respectively.

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Critical review of available evidence indicates that inferences have been made about the beneficial effects of risk factor modification without an adequate test of the hypothesis. We found that TNF-alpha, IL-1 beta, and IL-6 were undetectable in CSF of all children with prolonged febrile seizures and control subjects but that the concentrations of TNF-alpha was elevated in 11, of IL-1 alpha in 6, and of IL-6 in 17 of 23 children with acute encephalitis/encephalopathy. Evaluation of the ability of primary selective enrichment to resuscitate heat-injured and freeze-injured Listeria monocytogenes cells. PCBs as environmental estrogens: turtle sex determination as a biomarker of environmental contamination.

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Preliminary experience with phase-contrast magnetic resonance (MR) angiography at 0.5 T applied in 12 cases of vascular malformations of the spinal cord is reported. Levels of hippocampal NGF mRNA expression increased by 1 hr after injury and plateaued until 3 and 5 hr postinjury. A tessellation model is proposed to explain the generation of the precise hexagonal array of ommatidia in the eye. Rhythmic movement disorder, sleep starts, sleep talking, and nocturnal leg cramps--these four disorders belong to sleep-wake transition disorders in the International Classification of Sleep Disorders.

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Seven women were studied during the early follicular phase (day 1-4) of three different menstrual cycles after randomized oral administration of either 6 mg estradiol valerate or 15 mg norethisterone acetate or placebo. The quantum yield of the bovine rhodopsin E113Q mutant at pH 8.2, where the Schiff base is unprotonated, was significantly lower than that of wild-type rhodopsin, whereas the mutant gave a quantum yield almost identical to that of the wild type at pH 5.5, where the Schiff base is protonated. Blood samples were collected just before each dose of cyclosporine and for up to 36 hours afterward for pharmacokinetic analysis. Surgical treatment of meningoencephalitis complicated by septic hemorrhage FGF2 has higher apparent heparin affinity than FGF1 or FGF7, and FGF1 has higher heparin affinity than FGF7.

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The aim of this study was to assess the current influence of educational attainment and occupation on maternal obstetrical risk associated with cesarean section under the conditions of an industrialized country and provision of universal coverage. Activation of endogenous antioxidant defenses in neuronal cells prevents free radical-mediated damage. Congenital rubella in south India: diagnosis using saliva from infants with cataract.

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Micronized AlloDerm (Cymetra) is a presently available injectable substance made from human collagen and elastin particles. The amino acid sequence of the peptide fractions, totaling 205 amino acids, were identical to sequences contained within the extracellular domain of BPAg2. Subcellular fractionation studies indicate that sPLA2 activity and type IB sPLA2 immunoreactive protein are contained in insulin secretory granules. Evidence for protein phosphorylation and dephosphorylation in membrane fragments isolated from the electric organ of Electrophorus electricus.

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Epidemic, invasive, drug-resistant pneumococcal disease has not been seen among adults in the United States. To investigate the in vivo effect of beta-casomorphin-7 on the regulation of gastric somatostatin and gastrin messenger RNA in rat gastric mucosa. We have identified a novel gene, gtcA, involved in the decoration of cell wall teichoic acid of Listeria monocytogenes serotype 4b with galactose and glucose. One patient reverted to overnight mechanical ventilation (six hours) after three years.

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To identify key messages about pre-diabetes and to design, develop and pilot an educational toolkit to address the information needs of patients and health professionals. High-attenuation lymphadenopathy in AIDS patients: significance of findings at CT. Delayed nasal repairs in patients with CLP did not produce satisfactory aesthetic or functional results, probably because growth was retarded and midfacial development was disturbed at the time of delayed rhinoplasty and resulted in asymmetry.

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Two groups of patients with cataracts of different origin (a total of 110) are compared, in whom intraocular pressure was decreased by different methods before surgery: mechanical (convex compression) and combined (convex compression combined with hypotensive drugs). The dissociation of the complex allows for the detection of the components of the enzyme. After perfusion with solutions containing haemoglobin, the absorption values of calcium, copper and zinc were lower than after ferric citrate in both groups (control and iron-deficient rats). Differential photoacoustic cell for electrochemical and dynamic process with temperature control. chaquensis, thus in part explaining the difference in the magnitude of the responses.

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The clinical manifestation of the younger brother of the proband was Langerhans cell histiocytosis. The author describes a method of obtaining biologically-active 125I-labeled luteinzing hormone in iodation with chloramine T. The island of Cyprus was suffering for many years from malaria fever. Properties of a single-chain antibody containing different linker peptides.

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Circular DNA and DNA/RNA hybrid molecules as scaffolds for ricin inhibitor design. A contribution to the innervation of the urinary bladder of the cat. The ENZYMEBA test: detection of intestinal Entamoeba histolytica infection by immuno-enzymatic detection of histolysain. Cure can be achieved by complete surgical resection, but even in the low-aggressive tumours the long-term outcome may be unpredictable.

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Psychological well-being among people with recently diagnosed rheumatoid arthritis. The patients rated swallowing difficulty during the first postoperative 5 days using a 10-point score.

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Further investigation showed that incubation of monocytes in the presence of either BiP or IL-10 down-regulated CD86 and HLA-DR expression. The HopX (AvrPphE) family is a widespread type III effector among phytopathogenic bacteria. The involvement of orthodontics, in the prevention of CMD, has three impacts: functional, aesthetic and psychological, allowing for a better balance of the cranio-mandibular system. The test does not need to specify a parametric distribution for the random errors. Investigation of the frequency of different bacterial species, along with monitoring of the resistance is an essential prerequisite of initial antibiotic therapy of febrile episodes in neutropenic patients.

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Creation of new technology for conduction of controllable autonomous complex medical studies on board the MIR orbital station under the SHIPKA project Dynamical localization of atomic-beam deflection by a modulated standing light wave. Administration of silica sensitizes lipopolysaccharide responsiveness of murine macrophages but inhibits T and B cell priming by inhibition of antigen presenting function. Fulminant thrombotic thrombocytopenic purpura in systemic lupus erythematosus.

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It is postulated that cytotoxin P4 may affect mitochondria either indirectly, by stimulating intracellular processes after binding to the cell membrane, or directly by interaction with the mitochondria after penetrating into the cell. circumcincta, were negatively associated having D2 values much over 1. Impaired word recognition in noise by patients with noise-induced cochlear hearing loss: contribution of temporal resolution defect. Simultaneously concentrations and size distributions of natural radioactive aerosols were determined. Gastroesophageal reflux with combined caudal and halothane anesthesia in children

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Pre and post blood samples were taken, and rectal temperature and heart rate were recorded continuously throughout the test. The presence of infectious virus was demonstrated by its rescue, by virus isolation in cell cultures, from PBMCs during a one year follow-up. The surface phenotype of swine blood and tissue eosinophil granulocytes. In this study, we compared the genital tubercle anatomy of the androgen receptor (AR) deficient, fibroblastic growth factor (FGF)-10 deficient and Sonic HedgeHog (Shh) deficient mutant male mice to that of the wild type male and female mouse. Potential risk factors for cesarean delivery and neonatal intensive care unit (NICU) admission were then selected and subjected to bivariate analysis.

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Its purpose was to serve elders, targeting those in greatest social and economic need. This result has important implications for interpreting some data in the literature and cautions against the use of a toy model.

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In the molluscs of both age groups, the neurons with a high frequency of action potential displayed ultrastructural features of high activity in the organelles involved in protein biosynthesis. All patients were imaged with either cerebral angiography or magnetic resonance angiography. Elucidation of mitochondrial effects by tetrahydroaminoacridine (tacrine) in rat, dog, monkey and human hepatic parenchymal cells.

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Hyperinsulinemia concomitant with normoglycemia reduces plasma concentrations of tumor necrosis factor alpha and the catabolic hormone glucagon in lipopolysaccharide-induced systemic inflammation in pigs. Yet, intense thermal stimulation up to 48 degrees C results in a greater afferent activity.

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An artificial hemoglobin-like domain has been constructed by engineering the gene coding for the multi-domain flavohemoprotein from the bacterium Erwinia chrysanthemi. For the first time there were revealed changes (oscillations) of antigenic activity: formation of 3 peaks of which the middle was the highest.

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Even in the absence of CD28, CTLA4 plays an inhibitory role in the regulation of allograft rejection. In both skilled and spontaneous reaching, PT lesions reduced success more than RN lesions, suggesting a greater role for the PT in guiding limb movements. We conclude that sympathetic denervation results in increased expression of Cx43, which in turn, contributes to increased spontaneous and agonist-induced OA in VSM.

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Lowering administrative costs is a particularly good way to reduce health care expenditures since this decreases the cost without compromising the quality of services. Transforaminal lumbar interbody fusion (TLIF) is a relatively new technique that avoids the morbidity of an anterior approach and the nerve root manipulation of a posterior interbody fusion. Cooperativity and switching within the three-state model of muscle regulation. Analytical investigations on the effects of substrate kinetics on macromolecular transport and hybridization through microfluidic channels.

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A rare case of partial posterior interosseous nerve injury associated with radial head fracture. All these successfully infected rat tumors (EMV-MBDB, EMV-PW41 and EMV-290T) became less transplantable to and more rejectable in otherwise susceptible syngeneic rats. Effect of the A118G polymorphism on binding affinity, potency and agonist-mediated endocytosis, desensitization, and resensitization of the human mu-opioid receptor. A two-year follow-up tympanometric results have been analysed for 40 patients subjected to myringoplasty. Indirect hemagglutination (IHA) serum titers showed that the herd had been naturally infected with Ph biovar A, serovar 2 (PhA2) prior to the study.

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The transfected cells were assayed for their abilities to bind fluid-phase P-selectin and to support rolling adhesion of pre-B cells expressing P-selectin under hydrodynamic flow. Elucidation of the signaling cascade responsible for calnexin phosphorylation at these sites in vivo may define a novel regulatory function for calnexin in cargo folding and transport to the ER exit sites. To noninvasively measure arterial wall thickness in a group of patients with Williams syndrome (WS). The sixth patient revealed compound heterozygosity for Tyr-150-Cys and Tyr-261-Cys.

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Comorbid anxiety is common in depressive disorders in both middle and late life, and it affects response to antidepressant treatment. brucei did not hamper the growth of the other trypanosomatids, when separated by a filter with 0.2 microns pore size. These findings may be taken as evidence in support of the view that cAMP is involved in the positive chronotropic action of adrenaline on cardiac pacemaker cells. Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. The resulting expression of plasmid coding for beta-galactosidase was strongly controlled by buffer osmolarity during as well as after the pulse.

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edulis following controlled pollination experiments in order to evaluate the potential role of reproductive traits with respect to the invasive potential of these taxa. In situ hybridization with MAP2 antitense riboprobe showed increased hybridization signal intensities in the large neurons, which correlated with the pattern of immunoreactivity for MAP2.

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We report here a case of an alpha-fetoprotein (AFP)-producing intrahepatic cholangiocarcinoma (ICC) in an 81-year-old woman with chronic hepatitis C viral infection, suggesting malignant transformation of hepatic stem cells as a mechanism for hepatic neoplasia. We have previously demonstrated that PPAR gamma stimulates the terminal differentiation of adipocyte precursors when activated by synthetic ligands, such as the antidiabetic thiazolidinedione (TZD) drugs. Multiplexing fibre optic near infrared (NIR) spectroscopy as an emerging technology to monitor industrial bioprocesses. However, discrete changes in copy number occur at distinct loci, indicating the aneuploid nature of the lager yeast genomes. Because the antilipolytic and lipogenic effects of fluoroacetate parallel those of insulin, they may share a common mechanism.