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Bicusan (Bicalutamide)

Bicusan is a hormone-based chemotherapy. The NCI Drug Dictionary defines the compound as a “synthetic, nonsteroidal anti-androgen. Bicusan competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors.” Bicusan is used in combination with other agonists like leuprolide or goserelin for the treatment of metastatic prostate cancer. It works by blocking the normal effect of the male hormone androgen. The main type of androgens produced by the body are testosterone and dihydrotestosterone (DHT). These are formed in testes, adrenal glands and tumors themselves, and they stimulate the growth of prostate cancer cells. Bicusan blocks this ability in order to stop the growth and spread of cancer.

Other names for this medication:
Bicalutamide, Casodex, Bicalox, Bicalutamida, Bicusan, Bidrostat, Caluran, Calutide, Calutol, Capro, Cosudex, Imda, Lutamidal, Probic, Zolacos,

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Detrusitol, Clopidogrel, Rofucal, Pumpitor, Ambien, Amoxipenil, Tamsulosine, Amobiotic, Flamydol, Vitaxicam, Abilitat, Nicord, Pexeva, Baycip, Turimycin, Muzoral, Gabapentine, Larona, Bapex, Kalidren, Jufurix, Olina, Lasilix, Cameloc, Esoprazol, Ultraquin, Dasabuvir, Berlocid, Diflazon, Zycel, Liondox, Betamox, Prexanil, Medoclav, Kefentech, Tamosin, Suminat, Diseptyl, Symbal, Tulip, Omezyn, Divido, Gabator, Vidotin, Losacor, Virovir, Zicam,

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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Oligoclonality of Vdelta1 and Vdelta2 cells in human peripheral blood mononuclear cells: TCR selection is not altered by stimulation with gram-negative bacteria. I have also attempted to establish the primacy of this operation for James Daniel Hardy. However, our results also indicate that the activation of Ras is not sufficient to activate the migration machinery in tracheal and mesodermal cells. In consequence of such formation they are protected in the biofilm against the effects of antibacterial drugs and of the immune system. A live varicella vaccine (Oka strain) was given to susceptible household contacts of varicella to test the protective efficacy of the vaccination.

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All the patients underwent OCT of both eyes with the purpose to identify the MH, to define the size of IMH, to determine the stage of MH, to prove the connections between the internal limiting membrane and the posterior hyaloid and to perform differential diagnosis in doubtful cases. Its tip was oriented in the mid-corpus cavernosum by longitudinal and transverse sonography sections, as it drilled into the fibrous tissue. Either hyperhidrosis or anhidrosis may accompany a more serious underlying disorder. Gender differences in PANG appear to be related to differences in muscle size (MTH) and do not appear to contribute independently to the gender difference in FFM. The actin depolymerization promoted by YpkA was only seen in cells with other features of apoptosis, and was blocked by inhibiting apoptosis, indicating that actin filament disruption is likely to be a result, rather than a cause of YpkA-induced apoptosis.

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The effects of economic measures in the hospital on education in the nursing professions The economic well-being of Social Security beneficiaries, with an emphasis on divorced beneficiaries.

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Furthermore, transglutaminases (both TG2 and factor XIIIa), as well as vimentin, regulate structural alterations (inward remodeling) that occur in response to low flow states. This article is meant to introduce the clinician to several such agents, along with the antidotes useful in the management of exposure to these. Spontaneous thrombosis of a basilar artery traumatic aneurysm in a child. The software is primarily written in the Unix C-shell and is designed to integrate with standard statistical and graphics packages and permit analysis either under Unix or MS-DOS. The ins and outs of gene regulation and chromosome territory organisation.

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Quality end of life care: the case for a MediCaring demonstration. The life of Eugene Braunwald: a remarkable journey that began in Vienna.

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Do the combined effects of the asymmetric process of replication and DNA damage from oxygen radicals produce a mutation-rate signature in the mitochondrial genome? In addition, 50 patients with a history of lymphoma and chemotherapy were examined.

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Diarrhea, electrolytic imbalance and renal failure in 94-year-old male Risk factors for primary and subsequent anal sphincter lacerations: a comparison of cohorts by parity and prior mode of delivery.

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After condylar resection a decision on whether to proceed immediately to reconstruction has to be decided. In chloralose- and urethan-anesthetized, beta-adrenergic receptor-blocked rats, the aortic depressor nerves were cut and electrically stimulated to induce BVB. A series of 18 tumors with histological features of oligodendrogliomas, induced in the rat by means of transplacental ethyl-nitrosourea administration were studied for immunohistochemical demonstration of neuronal (synaptophysin and neurofilament protein) and glial (gliofibrillar acidic protein and vimentin) markers.

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The use of fewer previous DMARDs was associated with longer MTX survival. This finding led us to investigate the reactivity of pyrraline with thiol and hydroxy amino acids. These cells were isolated by Ficoll-Hypaque gradient from 10 patients with atopic eczema, and their responses were compared to 10 normal subjects. Immunofluorescent and western blot analysis indicated that nucleolin was translocated most efficiently to the nucleus in the small intestinal rat epithelial cell line (IEC-6) when cultured on laminin-coated plates. Fifteen goats were given two transthoracic injections into the lungs 21 days apart with live Pasteurella haemolytica biovar A, serovar 1 (PhA1) in agar beads.

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The kidney undergoes hypertrophy under conditions that paradoxically cause a loss of lean body mass, such as diabetes, acidosis, and chronic kidney disease. The quantity of innervation of limbs was highest in newly metamorphosed froglets, gradually decreasing with growth. Dephosphorylation with protein phosphotyrosine phosphatase abolished the activation of PtdIns 4-kinase while protein phosphatase 2A had no effect. Anatomical assessment of the bladder outlet and proximal urethra using ultrasound and videocystourethrography. We have also reported that female rats have more cardiac HSP72 than males.

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Reverse electron transfer from cytochrome c is impossible due to energy of NADH and alpha-glycerophosphate oxidation via alternative pathway in the presence of cyanide. Statins exhibit a proven safety profile, and possess a myriad of pleiotropic properties improving vascular endothelial function.

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This pattern of utilization may lead to higher healthcare costs among patients with diabetes who are depressed, regardless of race. Observation of ground-state Zeeman coherences in the selective reflection from cesium vapor. Adventitial changes in pulmonary vasculature in congenital diaphragmatic hernia complicated by pulmonary hypertension. Staff perceptions of the technical difficulty of procedures were complex and potentially helpful in designing intervention protocols.

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The subcutaneous form is the most frequently encountered by radiologists, with the lesion presenting as a superficial mass. Hypophysectomy in male mice resulted in as a high level of the expression as in female mice.

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This was because the duration time of the process of the initial contractile response was as short as 5 to 40 seconds, but that of the secondary contractile response was as long as 8 to 15 minutes. Mean pro-hepcidin level in human serum of healthy volunteers was 106.2 ng/ml.

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The use of desmopressin as a hemostatic agent: a concise review. and that there is continuous generation of extrachromosomal copies of the translocated c-myc sequences in ST486 and CA46 cells.

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The 382 women identified as having urinary incontinence in the main epidemiologic study in Quebec, Canada. Tolerability of piperacillin/tazobactam in children and adolescents after high dose radio-/chemotherapy and autologous stem cell transplantation. To test whether false positive results are the result of the release of endogenous endonucleases by proteinase K and can be abolished by pretreatment with diethyl pyrocarbonate (DEPC). Normal phase high performance liquid chromatography for fractionation of organic acid mixtures extracted from crude oils. Chemotherapeutic drug-induced apoptosis in human leukaemic cells is independent of the Fas (APO-1/CD95) receptor/ligand system.

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X chromosome cDNA microarray screening identifies a functional PLP2 promoter polymorphism enriched in patients with X-linked mental retardation. All seven patients had anesthesia by objective testing preoperatively and had a continuity defect at the time of operation.

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Although there is clear indication for removal of patent grafts in unresolved bacteremia, there are no guidelines for the management of clotted nonfunctioning grafts. Thus, to the best of our knowledge, we are reporting here the first case of bacterial pericarditis caused by nonencapsulated H influenzae in an immunologically competent adult. In this article, we report a study of 20 individuals who suffered from delusional jealousy. Antibodies to GBV-C E2 are captured on a solid phase coated with affinity purified E2 protein.

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Pedigree analysis of some of the affected Charolais bulls indicated there may be a genetic predisposition for this sperm defect. The transforming proteins of acute promyelocytic leukaemias (APL) are fusions of the promyelocytic leukaemia (PML) and the promyelocytic leukaemia zinc-finger (PLZF) proteins with retinoic acid receptor-alpha (RARalpha).

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Immediate allergy to local anesthetics remains extremely rare with less than 10 authentic documented cases being published to date. A modified transseptal approach to the sphenoid sinus and pituitary gland utilizing rigid endoscopy has been developed by the Departments of Otolaryngology, Plastic Surgery, and Neurosurgery at The Cleveland Clinic Foundation.

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Purification of poly(ADP-ribose) polymerase from Ehrlich ascites tumor cells by chromatography on DNA-agarose. During the resurgence of measles in the United States between 1989 and 1992, only viruses of genotype D3 were isolated. This study investigated 1) the relationship between marginal gap sizes and enamel demineralization, and 2) the influence of three cements on this enamel demineralization. It is suggested that the emergence of the second, smaller protein may represent a catalytically less active protein that arises in vivo, since its appearance was not affected by the inclusion of proteolysis inhibitors in the mitochondrial preparation buffers.

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Such receptors can be localized inside the cell, such as the nuclear receptors of thyroid hormones and the nuclear and cytoplasmic receptors of steroid hormones, or on the outer surface of the plasma membrane, such as the membrane-bound receptors of polypeptide hormones and neurotransmitters. GFP biofluorescence: imaging gene expression and protein dynamics in living cells. Together, these results demonstrate that the protection against spontaneous apoptosis associated with BLV is different in cattle and in sheep. We have investigated whether aldosterone, insulin, or activation of protein kinases has an effect on the phosphorylation of the channel.

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Activity-dependent regulation of dendritic BC1 RNA in hippocampal neurons in culture. The lag time is related to the rate of surfactant diffusion to the water-oil interface causing a reduction of the interfacial tension. This case report deals with a 14-year-old female who died from a non-valve-related cause 17 months after a Ross-Konno operation using a cryop-reserved viable pulmonary homograft for the right outflow tract. Assay of acetylsalicylic acid and three of its metabolites in human plasma and urine using non-aqueous capillary electrophoresis with reversed electroosmotic flow. Relationship between the beta-adrenergic receptor and adenylate cyclase.

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To determine the orientation and conformation of retinal within the binding pocket of this membrane bound receptor, an ab initio solid state 2H NMR approach was used. Interestingly, a selective expression of CST mRNA and not SS mRNA was only found in isolated cells of the human immune system, whereas different tissues expressed both SS and CST mRNA. Importance of aortography as a method of examination before surgery Perhydrohistrionicotoxin, at concentrations of 10(-12)-10(-7) M, depressed the current generated by iontophoretic application of acetylcholine to endplate regions of soleus and extensor digitorum longus muscles of rats.

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MRI appearance of lumbar epidural abscesses: report of three cases Relative systolodiastolic variations in diameter of the carotid artery in HIV-infected children were significantly lower than those in controls, but there was no significant difference in intima-media thickness. Standard percutaneous revaccination of children who receive primary subcutaneous vaccination.

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If this is not possible the defect is covered with either a skin graft or a flap and the latter is recommended from both a cosmetic and a functional point of view. This review summarizes the recent findings in neurocardiological PET imaging. The common mechanism underlying these four conditions may well be an immunological disturbance. Since the GnRH test became negative, no increase in hCG has been observed, indicating that the patient achieved complete remission.

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After a 6-week period of familiarization, each subject identified his/her preferred higher rate program (program B), and this was used for the evaluation. Maximum output of the right heart was 6.7 L/min in both experiments. Modeling of self-diffusion and relaxation time NMR in multi-compartment systems. FISH-assay for translocations is performed in accordance with classification of Tucker J.D.

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ICU management of the patient with intra-abdominal hypertension: what to do, when and to whom? A good knowledge of predictive models accuracy seems essential for their efficient and safe use, for example to predict the shelf life of a product. This suggests that XeHAND expression in the embryo is regulated by the ventralising signals of bone morphogenetic proteins. Three to eight different substitutions were made at each position.

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These results indicate that the primary effect of interferon in SV40 infected monkey cells is either to inhibit the transcription of early virus RNA or to enhance its turnover in the nucleus. Indeed, several aspects of cognitive aging seem to deal with modifications of processes directly involved in conscious processing.

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The pH values decreased with increasing depth and the changes in pH were found to be correlated with changes in magnetic susceptibility. The genomic diversity of a bacterial species is elucidated by comparative chromosome mapping. Among the microanalytical techniques, electron probe microanalysis (EPMA) is one of the most powerful.

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The cytotoxicity of dental composites has been attributed to the release of residual monomers from polymerized adhesive systems due to degradation processes or the incomplete polymerization of materials. Dermal fibroblasts from different layers of human skin are heterogeneous in expression of collagenase and types I and III procollagen mRNA.

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PD98059 and curcunmin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 lamotrigine patient information expression, whereas the effect of SB203580 was less noted. beta adrenergic substances increase platelet cyclic AMP in vivo and simultaneously block platelet aggregation. Borderline hypertension: relationship between job and psychophysiological profile. To subclone and express the new gene of Schistosoma japonicum (Sj) CAI and evaluate the immunoprotective effect of the recombinant molecule. Previous work has shown that these preparations are able to exert cytotoxic effects on carcinoma cells, the extent of which might be influenced by the host tree species and by the content of mistletoe lectin.