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Among newborn Hb F-Malta-I heterozygotes, it could be shown that the XmnI sequence alone had little, if any effect on gamma-globin gene expression, but interplay with the (AT)(X)T(Y) sites in cis and in trans may occur. Construction of a recombinant plasmid containing multi-copy CpG motifs and its effects on the innate immune responses of aquatic animals. Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia. Our data show that anti-Myc antibodies and some (but not all) c-Myc peptides from conserved regions of the c-Myc protein enhance the turnover of rRNA synthesized in homogenates of oocyte nuclei. Molecular analysis of Ras activation by tyrosine phosphorylated Vav.

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Direct hepatic vein anastomosis was done in 5 patients, graft replacement of the MHV was done in 1 patient, and graft replacement of the RHV was done in 2 patients. Existing models of the evolution of primate intelligence do not provide an adequate explanation of the apparent restriction of this phenomenon.

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The results account for the large difference between therapeutic levels (approximately 30 microM) in whole tissue and the concentration (approximately 500 microM) required to suppress excitation in isolated cells. Our study aimed at determining the changes in the redox status of adult rats as a function of folate intake.

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Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA. To determine whether leuprolide acetate (LA), given subcutaneously at the time of follicular maturity in stimulated cycles, can result in ovulation and in vivo fertilization.

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In the case of p-ANCA related vasculitis, however, there is the possibility of cerebral infarction seen as in this case. Efforts to understand the molecular basis for development of the postsynaptic specialization have brought new insights into extracellular matrix proteins and their cell-surface receptors. This study looked at the expression of the TJ protein ZO-1 and the corresponding permeability changes in dextran sulfate sodium (DSS) induced colitis in a mouse model.

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This competition may have consequences for the transport of both compounds in soil and hence for the contamination of groundwater. Muscle specimens were taken from the rectus abdominus and homogenized in many levels. Drug-induced modulation of IL-2 production in experimental murine trypanosomiasis. The foal was the 17th in a series of similar deaths that occurred on a farm since 1959. Differences in concentration ability among low- and high-SES Israeli students: a follow-up study.

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Daytime sleepiness is a morbid characteristic of obese patients with a potentially significant impact on their lives and public safety. TGF-beta1-induced nodule formation was inhibited by vacuum ionized gas treatment of the plate surface.

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The gametocytocidal EC90 of chloroquine (1 x 10(-6) M) and that of quinine (9 x 10(-7) M) were equal to the minimum inhibitory concentration of asexual stages of isolates of P. However, there was a marked difference in the features of the melatonin rhythm between the two groups, i.e., a rapid decline of the melatonin level from the nocturnal peak in the elderly group, suggesting that the off-set time of melatonin secretion advances with aging. We postulate that transduction of the light intensity information is mediated by changes in the pattern of melatonin secretion.

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The quandary facing the investigator of brain angiotensin receptors is the need to protect the radioligand from metabolic alteration while maintaining the characteristics of the receptors in situ. The immunofluorescence analysis demonstrated that large amounts of LPS-induced TNF-alpha accumulated primarily within Golgi complex. Randomised controlled trials that compared anti-leukotrienes with inhaled corticosteroids during a minimal 30-day intervention period in asthmatic patients aged 2 years and older.

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We determined the validity of the Spanish version of the Calgary scale (CDSS-S). Information about the required amplitudes was presented at various times before the synchronization signal.

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It had previously been suggested that UBC9 may select for SUMO based on its difference in electrostatic potential as compared to other E2s but the NCUBE exception suggests that this may not be the case. By integrating searches across organisms, the MSGR can identify pathway members whose coregulation is either ancient or newly evolved.

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Significant depressive symptoms at the time of 1996, 1998 and 2000 interviews were assessed using a short form of the Center for Epidemiological Studies Depression Scale (CES-D). In the present study we measured calcium-dependent, vesicular glutamate release, and calcium-independent, transport-mediated glutamate release patterns in the vertebrate retina to better understand the sources of elevated glutamate in neural tissue under ischemic conditions. Anecdotal reports suggested that horses were more tired on completion of the cross-country phase of short format events when compared with horses completing the cross-country phase of long format competitions, despite the absence of Phases A, B and C. Use of essential metalloelement complexes or chelates in biological studies. Aortic valve replacement may be potentially more complicated and require the use of more resources when performed in octogenarians rather than in younger patients.

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Determination of HCV RNA concentration by direct quantitation of the products from a single RT-PCR. Biopsies were taken from the treated areas at the final visit to verify clinical clearance. Data on 18 patients fulfilling DSM-IV diagnostic criteria for bipolar I disorder were analysed. A moderate reduction in beta-NGF levels was seen in the serum of patients with ALS and MS. This study indicates the importance of the microarthropod gut for enhanced conjugative gene transfer in soil microbial communities.

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Recently, we found the presence of stress-sensitive CINC expression in the hypothalamic nuclei such as the paraventricular nucleus. Pseudomembranous bronchitis (non-diphtherial) resulting in sudden death: an autopsy report. Genetic factors influencing endogenous type-C RNA viruses of mouse cells: control of viral polypeptide expression in the C57BL/10 strain.

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In traditional Chinese medicine several Aristolochia species are used. KINETICS OF THE INDUCED BIOSYNTHESIS OF ISO-1-CYTOCHROME C AND ISO-2-CYTOCHROME C DURING ADAPTATION TO OXYGEN

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Extragonadal germ cell tumors are rare and have been described in case reports. Polymorphisms in the CYP19 gene confer increased risk for Alzheimer disease. Identification of Chinese traditional drug baijiangcao by ultraviolet spectrum It was shown that the clinical and bacteriological effects did not significantly differ in the patients under the parenteral regimen with cefuroxime and under the parenteral-to-oral regimen with cefuroxime and cefuroxime axetil: the cure in 75 and 83 per cent of the patients and the bacteriological response in 100 and 86 per cent of the cases respectively. Molecular pathways involving genes associated with inherited cancer syndromes could represent mechanisms of chemoresistance.

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These second-generation instruments are likely to find an increasing number of applications, including the on-line monitoring of fermentation and other bioprocesses. There is little support in the dental literature to justify the use of lasers for periodontal root therapy.

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25 eyes had the manifestation of chronic open angle glaucoma in the clinical course, and 1 eye simulated an acute glaucoma attack. Results indicated a significant interaction effect involving subject group and aided message length. Because the large diversity in the user interfaces (UIs) of different prediction servers for PTMs could possibly hinder experimental biologists in using these servers, we propose to develop a protocol for a unified UI for PTM prediction servers, based on our own work and that of other groups on PTM site prediction. The natural history of major aortopulmonary collateral arteries (MAPCAs) in patients with pulmonary atresia and ventricular septal defect (PA-VSD) is frequently complicated by progressive stenosis, leading to pulmonary hypoperfusion and debilitating hypoxaemia.

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The influence of tonsillitis on oral and throat muscles in adults. The present study was designed to evaluate the role of central corticotropin-releasing hormone (CRH) in the mechanisms mediating these conditioned effects.

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A four-year investigation of the seropositivity of Toxoplasma gondii in our hospital In light of previous findings indicating that inhibition in the lateral amygdaloid nucleus arises mostly from local inhibitory neurons, these results suggest that interneurons are synaptically coupled via GABAA receptors.

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This is the first report that shows that CSNB-associated mutations in three different domains of mGluR6 abolish proper protein trafficking. We hypothesize that the responsible mechanism is cAMP-dependent sensitization of IP(3) receptors for the high basal level of IP(3) caused by GHSR constitutive activity. Complex composite odontoma associated with impacted tooth: A case report. The physiological or pharmacological role of glucagon in the postprandial regulation of gastrointestinal motility has not yet been clarified.

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There is increasing evidence that breath analysis may have an important place in the diagnosis and clinical management of asthma, COPD, primary ciliary dyskinesia (PCD) and other major lung disease. Anticarcinogenic activities of carotenoids in animals and cellular systems.

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Long-term administration of a cholesterol diet produces an increase in the content of palmitic acid and stearic acid and a decrease in the content of oleic acid, linoleic acid and arachidonic acid in the myocardium. To better elucidate the nature of the IKK signalsome, we set out to identify IKK-associated proteins. Quantification of factors contributing to length of stay in an acute psychogeriatric ward. Thus, the differential diagnosis of pulmonary tuberculosis includes very many diseases.

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During the last decade, several investigators have argued that protein restriction instituted at an early phase in renal disease may influence the rate of progression of renal failure favourably. To present a theoretical framework to assess the potential value of identifying cost-effective treatments for individual patients given their preferences and to compare the value of individualized treatment decisions with the value of treatment decisions based on traditional population-level cost-effectiveness analysis.

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A conversion was defined as a (new) latex SPT with wheal diameter at least 4 mm greater than saline control. The level of organochlorine compounds was determined in whole capelin, Mallotus villosus, and compared to concentrations determined in tissues of yellowtail flounder, Pseudopleuronectes ferruginea, that fed on capelin for 2 years while maintained in tanks. Both patients were operated upon after appropriate radiological evaluation. Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. The present study showed that repeated cocaine administration decreased alcohol consumption in C57BL/6J mice without altering the metabolism of ethanol.

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These findings are discussed in relation to the mechanism of transcriptional activation and the evolutionary role played by retrotransposons. The use of the concentration profiles of the metal ions as a means of historical monitoring of trace metal contamination is complex for Pb, Zn, Mn and Ca but may be more straightforward for Cu and Cd. Ring chromosome 18 (46,XX,r(18)) has previously been reported in about 70 patients.

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Further kinetics will be necessary to precisely define sod transcriptional regulation during N. Discrepancies in published reports prompted this study of ATPase in non-neoplastic breast and infiltrating ductal carcinoma.

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It is also related to glial factor-1 (GF1), an incomplete version of HSmuBP2 lacking the first 494 and the last 128 amino acids. Collagenase immunolocalization in cultures of rheumatoid synovial cells.

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The average annual incidence rates of invasive pneumococcal disease were calculated and clinical characteristics were reviewed. Understanding the role of the essential Asp251 in cytochrome p450cam using site-directed mutagenesis, crystallography, and kinetic solvent isotope effect. After 1 year of followup, most of the parameters had returned to baseline values in both groups.

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Intracerebral source localization of mental process-related potentials elicited prior to mental sweating response in humans. At a free surface cluster dissolution may take place instead of domain growth, yielding stationary dynamical correlations that decay in a stretched exponential form. Sprague-Dawley rats, normal and chemically sympathectomized with 6-hydroxy-dopamine, were trained by treadmill running. To study the prevalence of abnormal glucose tolerance among women with a single abnormal glucose tolerance test value in previous pregnancy and identify factors predictive of the later development of abnormal glucose tolerance in this group. In the presence of unexplained leg symptoms, peripheral arterial disease can be diagnosed or ruled out by non-invasive diagnostic methods such as history, clinical examination and the measurement of ankle and brachial artery pressure by Doppler ultrasound, as well as by calculating the ankle brachial index.