Seven pigs were treated with daily intramuscular injections of Clonac 3 mg/kg for 7 days. The permeable behaviors of sodium Clonac through SC and intact skin of snake, porcine and human were compared. The analgesic potencies of the combinations of morphine and Clonac (ratios, 1:5.66 and 1:10), morphine and propacetamol (ratio, 1:250), and Clonac and propacetamol (ratio, 1:65.7) were thereafter evaluated and compared with the effects of the drugs alone.
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