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Signature pattern analysis identifies particular sites in amino acid or nucleic acid alignments of variable sequences that are distinctly representative of a query set of sequences relative to a background set. Yet, the relatively low intratumoral hyperplasia, suggests that endothelial cell migration and capillary remodeling play an important role in neovascularization of prostatic carcinoma, especially when compared with granulation tissue, which showed a 43-fold greater endothelial cell proliferation index. This means that high-resistance small-caliber endotracheal tubes have to be replaced by large tubes. Dental status was determined by a so called total dental index (TDI) which reflects primarily caries, periodontitis, periapical lesions, devital and missing teeth as well as by a panoramic index (PI).

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Agouti (A(y)/a) mice did not respond to ADP or leptin, indicating the melanocortin pathway may be a common target. Increased epidural analgesia use did not change the overall dystocia cesarean delivery rate, although dystocia was more common among women who chose an epidural analgesia. Liver biopsy findings in patients with juvenile rheumatoid arthritis receiving long-term, weekly methotrexate therapy. Fusion of ubiquitin in-frame to a receptor that lacks cytoplasmic tail lysines also promotes rapid receptor internalization, indicating that ubiquitin itself and not a specific type of linkage to the receptor acts as an internalization signal.

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The above demonstrates that the peptidergic system has a primary role in the complex pathogenetic mechanism of the allergic asthma. Sharpness of vertices from night-driving was significantly sharper than with day-driving. Comparison of effectiveness of two urinary drainage systems in intensive care unit: a prospective, randomized clinical trial. Surgery was performed and was complicated by severe corneal ulceration. To compare 2 clinical wound scales and to determine a minimal clinically important difference (MCID) on the visual analog cosmesis scale.

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A series of recent investigations have also indicated that the magnitude and possibly the predictability of the expected outcomes are dependent upon a variety of patient, defect, and procedure-associated factors. This study examined the number of days that prisoners spent in a special disciplinary housing unit in New York State prison before a suicide occurred. Outcomes of transconjunctival sutureless 25-gauge vitrectomy with silicone oil infusion.

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The intra-aortically administered ferritin particles appeared in the interstitium of the distal part of the afferent arterioles. Herein we report for the first time the effects of an ER-Golgi transport inhibitor, Brefeldin A (BFA), alone and in combination with a small molecule Bcl-2 inhibitor HA14-1 or agonistic anti-Fas mAb, in the recently established human FL cell lines.

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Increasing syphilis cases among MSM account for most of the recent overall increase in rates and may be a harbinger of increasing rates of HIV infection among MSM. Differential induction of c-fos and c-jun proto-oncogenes and AP-1 activity by tumor promoter 12-O-tetradecanoyl phorbol 13-acetate in cells at different stages of tumor promotion in vitro. Point mutations in the p53 tumor-suppressor gene are the most frequently identified genetic alterations in human malignancies.

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Red cell bound IgM and IgG autoantibodies were predominant in levodopa-injected mice whereas red cell bound IgA autoantibodies were predominant in levodopa-fed mice. pelagius to the rearing water seemed to improve larval survival compared with fish exposed to Aer.

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Our appreciation of their roles in these processes is hampered by a lack of understanding of their soil-borne mycelial systems. Treatment with loxiglumide (Loxi-3 and Loxi-4) or CCK-8 for 6 days (CCK-4) or with a high dose of loxiglumide for the first 3 days (Loxi-2) significantly suppressed the recovery of pancreatic weight and DNA content compared to saline treatment or to the untreated normal control rats. To investigate the signaling mechanism whereby Gbeta gamma regulates the activity of JNK, we transfected kinase-deficient mutants of two JNK kinases, mitogen-activated protein kinase kinase 4 (MKK4) and 7 (MKK7), into human embryonal kidney 293 cells.

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Fetuin expression was present in germinal cell populations, e.g., in the basal layer in the skin, in the germinal cell populations in the brain anlage and the gonads, and it was heavily expressed in the fetal hemopoietic liver. Stejnefibrase-2 degraded preferentially Bbeta-chain while stejnefibrase-1 and -3 cleaved concomitantly Aalpha and Bbeta-chains of fibrinogen. A horizontal optokinetic nystagmus (OKN) was elicited by a vertical rectangular grating presented on a PC-screen and was recorded by an infrared reflection method. Standardization of methodology and establishment of quality control standards in the performance of these tests could facilitate their integration into clinical practice as adjuncts to existing cardiovascular risk stratification algorithms. A new concept is proposed in this paper to ameliorate these problems based on a miniaturized magnetic drive, and a prototype is introduced.

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The TMBA identified in fruiting bodies was an active ingredient whose functions consisted with the reported experiences of this mushroom. pKa calculations of aliphatic amines, diamines, and aminoamides via density functional theory with a Poisson-Boltzmann continuum solvent model.

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Overall fracture risk was increased prior to diagnosis of HPT but not afterward. Compared with men, women were likely to be more aware of the consequences and chronicity of depression.

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At initial examination, these wounds appear similar to atypical gunshot or stab wounds. This article describes the 35S release cytotoxic assay, which measures the ability of NK cells derived from spleen cells taken from polyIC-treated mice to lyse B-cell leukemia (BCL1) cells. These results were seemingly correlated with the effects of the membranes on complement activation. Further investigation of larger and different population samples in order to assess the role of adducin gene polymorphism as a marker of genetic predisposition to the development of hypertension is warranted.

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PKA phosphorylation of KID in the DNA-bound state induces a phosphatase-resistant conformation that may prolong transcriptional activity. Immediate endoscopy may be considered if CT is not available, although it adds significant cost.

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In contrast to the heteronuclear quadruple-quantum coherence (HQQC) approach, the QQF-HSQC allows for long constant-time (CT) evolution, making use of the generally favorable relaxation properties of methyl groups. Tumor oxygenation is dependent on the cellular O2 consumption rate and on the O2 supply to the respiring cells. Accurate knowledge of partial anatomy is essential in hepatic surgery but is difficult to acquire. Apoptosis overview emphasizing the role of oxidative stress, DNA damage and signal-transduction pathways.

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The specificity of mAbs was tested by ELISA and Western blot analysis. Human skeletal muscle in bacterial infection: enzyme activities and their relationship to age. Physical morbidity was associated with patient problem behaviors and cognitive impairment, and with caregiver depression, anxiety, and perceived social support. Several linkage studies have shown significant linkage of schizophrenia to chromosome 6p region, which includes the positional candidate genes, Dystrobrevin-binding protein 1 (DTNBP1).

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Molecular characterization of a pea beta-1,3-glucanase induced by Fusarium solani and chitosan challenge. Vascular endothelial growth factor (VEGF) is secreted by tumor cells and coordinates with Ang to promote angiogenesis. Both smooth muscle (SM) and nonmuscle class II myosin molecules are expressed in SM tissues comprising hollow organ systems.

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An 18-month postacute case management pilot project collected data on a nurse-specific and patient-specific basis. Polycyclic aromatic hydrocarbons in fish from remote and high mountain lakes in Europe and Greenland.

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However, partial loss-of-function mutations in rolled enhance the abnormal spindle (asp) phenotype, whereas gain-of function mutations in rolled or in the gene encoding its activating kinase Dsor1, act as suppressors. Late relapse of myelodysplasia after allogeneic transplantation concomitant with new presentation of invasive liposarcoma as a secondary neoplasm. In the present study, by using a RT-QPCR and QPCR strategies, we show that spliced viral RNAs are present in infectious particles and consequently participate, along with the unspliced genomic RNA, to some of the early steps of infection such as the reverse transcription step. Nd:YAG laser pulses at 10-20 W and 15-60 s produce homogeneous myocardial lesions of coagulation necrosis of reproducible sizes, in a controllable manner, without unwanted effects on the ventricular walls, in normal and through scarred myocardium of dogs. A 47-year-old man with acquired immune deficiency syndrome was found to have disseminated Saccharomyces kluyveri infection.

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Expression also occurred in differentiating placodal tissues and in mesodermal cells. This finding indicated that the decoupling of rotational and translational degrees of freedom in phase transitions in confined systems previously found for benzene is not restricted to molecules with non-specific interactions, but represents a more general phenomenon. Conversion from cyclosporine to tacrolimus in renal allograft recipients with chronic graft nephropathy: preliminary report. This influence is seen in delayed asylum closure, transinstitutionalisation (the shift of some patients from asylums to other institutions), and the institutionalisation of aspects of community care.

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To develop a user-friendly observer-rated dementia screening questionnaire with strong psychometric properties for adults with intellectual disabilities. The NRE, however, appeared to cause constitutive down-regulation of UL94 promoter activity.

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The genus Mycobacterium harbours a number of significant pathogens. The patterns of fragmentation produced by MALDI mass spectrometry, particularly where standards are available to calibrate the spectrum and the energy of the laser is controlled, can be used to predict the type of linkage present. Lung cancers are a heterogeneous group of tumors broadly classified as small cell or non-small cell lung cancers.

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Effects of fibronectin on articular cartilage chondrocyte proteoglycan synthesis and response to insulin-like growth factor-I. Qualitative reverse transcription (RT)-PCR demonstrated that all colorectal cancer cells examined expressed GCC mRNA. Simultaneous visualization using double immunogold labelling after in situ hybridization and immunocytochemistry. Functional analysis of the human TAFII250 N-terminal kinase domain. These results demonstrate that the combination of both liposomal lipids and liposomal protein is required for Golgi-specific targeting of liposomal antigens.

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We recommend that cardiac rhythm be monitored throughout procedures performed under peribulbar anaesthesia, and that a vagolytic agent be available for immediate use. Infants were separated from their mothers at birth, and dosed with the same dose their mothers had received. The study group consisted of 95 out of 128 patients who underwent mitral valve repair for ischemic mitral insufficiency at the Department of Cardiac Surgery of the Heart Center of Kaunas University of Medicine in 1996-2002. In patients with localized renal cell carcinoma and an inferior vena caval tumor thrombus the cephalad extent of inferior vena caval involvement does not appear to be prognostically important. We tested whether low-level cadmium and reduced calcium intake affect tissue cadmium concentrations and behaviour of captive black ducks.

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Here we show that treatment of K562 cells with the phorbol ester TPA induces the down-modulation of various surface antigens. The distribution of the retrogradely-transganglionically transported lectin soybean agglutinin (SBA) and of SBA conjugated to horseradish peroxidase (SBA-HRP) has been examined in the L4-5 dorsal root ganglia, lumbar spinal cord and gracile nucleus at 2, 6 and 14 weeks after sciatic nerve transection and ligation. These factors reflect two broader themes of attitudes toward or assessments of the EBP itself and experiences with learning and delivering the EBP. The resulting lattice is comparable to those seen for complexes of other lectins with branched glycopeptides.

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Offspring were derived from Sprague-Dawley dams that had received subcutaneous injections of 40 mg/kg/3 cc cocaine hydrochloride (C40) daily on Gestational Days 8-20, pair-fed (PF) dams that were injected with saline, nutritional control dams (NC) that had received saline injections, and nontreated control dams (LC). Although robust, its efficiency greatly depends on the choice of preconditioner.

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In vitro contact phase activation with haemodialysis membranes: role of pharmaceutical agents. Stress mediators, CRF-41 and vasopressin known to be synthesized in, and released from the parvocellular neurosecretory neurons of the hypothalamic paraventricular nucleus (PVN) are essential to release adrenocorticotropin (ACTH) in response to stress. The peculiar coordinated regulation of Ex-FABP, CAL beta and CAL gamma, and the apparent divergent role of Ggal-C8GC suggest that these gene duplications may have been maintained during evolution by a sub-functionalization mechanism where some common function(s) are shared by several members of the cluster and some other specialized function(s) are unique to other members.

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The proposed RLSP method clearly outperformed the weighted k-nearest neighbors imputation (kNNimpute) method and LLSimpute method, and showed competitive results with Bayesian principal component analysis (BPCA) method. In a retrospective study the first 50 implantations of the pedestal cup in our hospital for high-grade acetabular defects (Paprosky classification II and III) were examined after a medium period of 26 months. A psychometric evaluation of the Defense Style Questionnaire in methadone patients. The degree of toxicity was estimated from the percentage of damaged cells seen in the dye exclusion test and from the amount of lactate dehydrogenase and lactate released into the medium in the case of macrophages. Histopathological evaluation of disease progression was based on hematoxylin-eosin and oil red O staining and immunocytochemistry for T cells, macrophages/microglia, astrocytes, and oligodendrocytes.

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The present status of the project and its further developments are discussed in the Conclusions. NEW THERAPEUTIC POSSIBILITIES FOR THERMONUCLEAR DAMAGE AND BURNS Important discoveries have been made in pathogenesis and mechanism of disease, with great emphasis on the many pathways leading to oxidative stress, and the novel mechanism of endoplasmic reticulum stress that is proving to be important in the pathogenesis of many liver diseases. Furthermore, we showed that the kinase activity of IRAK4 was not necessary for IL-1-induced IRAK phosphorylation, suggesting that IRAK phosphorylation can probably be achieved either by autophosphorylation or by trans-phosphorylation through IRAK4.

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Comparative neuromuscular effects of lincomycin and clindamycin. Dietary intakes of both calcium and vitamin D and serum 25 OH D levels were found to be comparable in both groups. Users of fentanyl transdermal system and other long-acting opioids experienced essentially identical evolution of health services utilization and costs over a 2-year period.

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Unique dimeric structure of BNip3 transmembrane domain suggests membrane permeabilization as a cell death trigger. Topical tretinoin replenishes CD1a-positive epidermal Langerhans cells in chronically photodamaged human skin. The most sophisticated toxins comprise at least two functional domains or components, one being a binding domain permitting the internalization into the cell of an enzymatic domain which modifies an intracellular target. Analyses of DNA ploidy, proliferative activities, and immunophenotype by flow cytometry (FCM) are useful for diagnosing intermediate- and high-grade NHL.

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The semi-essential amino-acid taurine is involved in glucose homeostasis either in adults or in parental life. The zebrafish Pard3 ortholog is required for separation of the eye fields and retinal lamination.

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We sought to determine whether it is beneficial to routinely include a single reformatted oblique sagittal view as an adjunct to coronal computed tomography (CT) for the evaluation and treatment of orbital floor fractures, when imaging is obtained on patients with orbital trauma. All four proteins were detected specifically in tissues that are known to depend upon vitamin A for normal development including the yolk sac, heart, gut, notochord, somites, sensory placodes and the limb. The battery clearly differentiated the performance of the clinical participants from that of the normal controls. A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.

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Combinations of mecillinam and 6-APA with ampicillin acted synergistically against the gram-negative bacilli. The primary aim of this study was to evaluate if pulmonary rehabilitation in a subtropical climate during winter had better long-term effects on health-related quality of life and symptoms of anxiety and depression than an equivalent pulmonary rehabilitation program in a colder climate. Conceptual and methodological issues in nurse case management research.

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The place of the action of the serotoninergic system in the 2-stage process of the formation of latent inhibition in rats The dielectric relaxation spectrum of polycaprolactone (PCL) networks hydrophilized with different amounts of 2-hydroxyethyl acrylate (HEA) is investigated. A single-dose oral toxicity performed in accordance with the OPPTS 870.1100 and OECD 401guideline showed that DAT was not toxic. Chest X-ray film on admission showed an abnormal mass lesion in the right upper mediastinum.

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VPA entrapped in positively charged liposomes showed a prolonged anticonvulsant effect lasting for 2 days, while the effect evaluated at 1 h was not different from that with free VPA. To this aim, here we present a protocol based on terminal perfusion of mice with a reactive ester derivate of biotin that enables the covalent modification of proteins readily accessible from the bloodstream. However, in the treatment of partial edentulism, clinical reality often predicates the consideration of splinting teeth and implants due to variables of tooth/implant location and available bone support. Most of the assays showed immune reactivity against the DV or LV vaccine demonstrating the cross-reactive potential of such a vaccination approach.

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To study, by literature review, the management of subclavian-axillary vein thrombosis (SAVT) and to make recommendations. Gender differences of enzymatic activity and distribution of 17beta-hydroxysteroid dehydrogenase in human skin in vitro. The nonspecific cytoplasmic staining that occurs in indirect immunofluorescence tests for CMV did not occur in the ACIF system, and sera that were anti-complementary in complement fixation tests could be examined satisfactorily by ACIF. Light and the recovery from heat shock induce the synthesis of 38 kDa mitochondrial proteins in Neurospora crassa. The mental representations of parents were characterized by differences in accessibility and sense of continuity as well as socio-emotional, sexual and activity-related aspects of mental representation.

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The tetA(C) gene was mutagenized with hydroxylamine, and missense mutations causing the loss of tetracycline resistance were identified at 30 distinct codons. Rapid dose initiation of quetiapine for the treatment of acute schizophrenia and schizoaffective disorder: a randomised, multicentre, parallel-group, open study. A rank system for the variability of the chaetoid integument in females The effect of isoflurane or sevoflurane on circulating blood volume--a study under controlled ventilation A review of the significant findings related to the use of the thiazolidinediones (TZDs) in the treatment of patients with type 2 diabetes mellitus and heart failure was conducted.

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An incorrect initial diagnosis led to delay in treatment and subsequent neurologic deterioration in six patients. However, when mice are exposed to a psychosocial stressor (social disruption by transferring mice from isolated to grouped conditions, and to a moderate extent a transfer from grouped housing to isolation), the effects of IFN-alpha on sickness, plasma corticosterone and hippocampal norepinephrine, as well as on the levels of circulating IL-6, TNF-alpha and IL-10 (but not IL-1beta or IFN-gamma) are greatly augmented.

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Microcapsules were formed after solvent evaporation, the solidification of the microcapsule walls was followed by an optical method. Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry. The authors report a very unusual and unique case of pancardiac tuberculosis in a 25-year-old man who presented initially with atrial flutter with 1:1 conduction. Radioimmunoassays of tetrahydrocortisone and tetrahydrocortisol in human urine. The median diameter of lesions was significantly reduced, from 9.9 mm (range, 5.5-25.0 mm) to 5.3 mm (range, 0.0-17.0 mm) by PEIT.

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This drug combination could be of great benefit when administered before temporary artery occlusion in patients undergoing cerebrovascular surgery. Radiation-matter oscillations and spectral line narrowing in field-correlated four-wave mixing. This review discusses the above issues and highlights a variety of biotherapeutics that have been administered as inhalation aerosols. Many practical pattern recognition problems require non-negativity constraints. Inhomogeneous pair distribution functions and wetting transitions for a model Ar-CO2 interface.

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These data suggest that the change in carotid flow produced by vancomycin, is dependent, in part, on either H1 or H2 receptor activation. Overexpression of Rad51, a protein central to DNA strand exchange and recombination, did not further increase the frequency of recovered translocations but did increase the frequency of long-tract gene conversion events associated with loss of heterozygosity and tandem duplications. The symptoms may appear spontaneously or result from a stimulus, usually trauma. Frequency and severity of headache after lumbar myelography using a 25-gauge pencil-point (Whitacre) spinal needle. Addition of bicarbonate (or alkalization of medium) raised steady-state levels of mRNA in respiration-deficient mdh1 mutants and inhibited proliferation of wild-type cells at low density.

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Decompression induced venous gas emboli in sport diving: detection with 2D echocardiography and pulsed Doppler. Mutation of a single surface exposed residue, Lys12 to Met, in the N-terminal domain of the ribosomal protein L9 (NTL9), significantly increased the stability of the protein and led to faster folding.