Finlipol is used together with diet, weight loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Finlipol is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol ('bad cholesterol') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol ('good cholesterol') in the blood. Finlipol may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Finlipol is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats with Finlipol has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks.

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Detection of large pathogenic expansions in FRDA1, SCA10, and SCA12 genes using a simple fluorescent repeat-primed PCR assay. Detection of mitogen-activated T and non-T lymphocytes by virus plaque assay. Frequent overexpression of the cyclin D1 oncogene in invasive lobular carcinoma of the breast. Such an assay system proved to be as efficient as the other available rotaviral antibody systems.

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Sleep-wake center consists of two parts, one is sleep center which is present in the anterior parts of hypothalamus, and the other is wake center which is present in the ascending reticular activating system including posterior parts of hypothalamus. We evaluated whether geographic factors are responsible for this observed variation. A direct end-labelling approach was used to measure the excision of damaged oligonucleotides by NER and no inhibition by p21 was found. Members of this gene family are expressed early in embryogenesis, providing molecular markers for meristem initiation. Treatment of chronic hepatitis B with interferon may lead to transient decompensation of liver function, especially in patients with high activity of morphological changes.

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XeCl laser ablation of atherosclerotic aorta: optical properties and energy pathways. These observations may have particular relevance for staphylococcal infections, in which clinically achievable beta-lactam concentrations do not suppress staphylococcal growth yet may alter and possibly enhance virulence. Similarly, 10 patients had peak levels less than 7 ng/ml and one patient had a peak level of 7-10 ng/ml with L-dopa.

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Presynaptic inhibition of spinal alpha motoneurons in humans adapted to different types of motor activity Since there are few precisely known phylogenies, simulations are typically used to test the quality of reconstruction algorithms. Irregular bleeding patterns were common but well-tolerated, and the implant had a high continuation rate.

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Characterization of a fetal calf serum-derived molecule reactive with human natural antibodies: its occurrence in tissue culture-grown type C RNA viruses. Aromatase p450 (p450arom) catalyzes the formation of estrogen in several human tissues under the control of alternatively used promoters. Immunopositivity for parafibromin and intensity-percentage scores were derived by blinded evaluation. The ventricles were developed to fit within the pericardial space based on the results of anatomic fit trials. Most comorbid associations of depressive symptoms with specific chronic illnesses are explained by accompanying poor self-reported health and functional status, but some illnesses probably have a direct psychobiological basis.

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The RT-PCR products obtained using exons 2- and 3-specific oligonucleotides showed a high degree of sequence homology with exons 2 and 3 of the h-mts1 gene. Modified RIFLE criteria in critically ill children with acute kidney injury. Antibiotic resistance genes carried by LAB and bifidobacteria can be transferred to human pathogenic bacteria either during food manufacture or during passage through the GIT. Randomised trials in children and adults comparing Fluticasone to either Beclomethasone or Budesonide in the treatment of chronic asthma. Fractionation of acid phosphatase by gelelectrophoresis in separated lymphocytes demonstrates especially isoenzyme 3, in separated macrophages isoenzyme 4.

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This occurs in part via an effect of CRP to reduce EPC eNOS expression. Confusions on interpreting the physiologic rationale of gas-exchange variations as associated with lung recruitment are still widespread. It has been found that patients with CHF having an accompanying CTPV have relatively large splenomegaly and suffers more frequent episodes of bleeding from esophageal varices. Mutants of SV40 with deletions of various sizes mapping between 0.54 and 0.59 on the genome grow at a rate equal to or slightly slower than that of wild-type virus, in a range of host cells. Secure persons scored lower in anger-proneness, endorsed more constructive anger goals, reported more adaptive responses and more positive affect in anger episodes, attributed less hostile intent to others, and expected more positive outcomes than insecure persons.

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While normal mammary tissue showed an intact epithelial BM, as evidenced by a continuous linear staining for collagen i.v., laminin, heparan sulfate proteoglycan (perlecan) and fibronectin, this staining was widely lost in the invasive carcinomas. The results for haloperidol yielded an increase in surface tension and an decrease in in vitro BUT. Three-dimensional photoelasticity models of the knee joints were made of epoxy to observe the change in the status of stresses according to the size of defect in the meniscus.

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Recrudescence of chronic infection could be elicited by daily intraperitoneal injections of 4.0 mg of dexamethasone. The interview mode effect on the Center for Epidemiological Studies Depression (CES-D) scale: an item response theory analysis. Ulnar nerve dysfunction in inflammatory-degenerative conditions of the elbow joints

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Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an unknown mechanism. Vitamin D metabolism is unchanged as far as the stage of 25-hydroxycholecalciferol. These data suggest that members of the subtilisin-related proprotein convertase family mediate processing of pro-IGF-2 at Arg104. The putative pathophysiologic significance of the reduced expression of paraventricular nitric oxide synthase in depressive patients might be related to the supposed regulatory function of nitric oxide in the release of corticotropin-releasing hormone and arginine-vasopressin and/or oxytocin, which have been reported to be over-expressed in the so-called endogenous psychoses, especially in depression.

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Using four electrophoresis units, one technician can analyze 400 PCR fragment samples in 2 h. The development of chlorophyll (Chl) a fluorescence imaging systems has greatly increased the versatility of Chl a fluorometry as a non-invasive technique for the investigation of photosynthesis in plants and algae. Eigenvectors and eigenvalues for the Keilson-Storer collision kernel.

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Preliminary results are in fairly good agreement with those available in the literature. Enzymatic determination of BPA by means of tyrosinase immobilized on different carbon carriers. Leucocidin, one of the cytotoxic principles of Pseudomonas aeruginosa induces potassium loss and swelling in isolated hepatocytes and in AS-30D ascites hepatoma cells in a dose and time dependent manner. The tmRNA linker helix, as well as the long variable arm of class II tRNA, may occupy the gap between the large and small ribosomal subunits. State-selective velocity and angular distributions of NO molecules scattered from a graphite surface.

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Eighty glial and non-glial brain tumors have been studied to date using an immunologically specific and highly sensitive method of staining GFA protein which is applicable to formalin fixed and paraffin embedded tissue. Immobilized peptides containing phosphorylated Tyr579, Tyr581 or Tyr775 bound Stat5, suggesting direct binding of Stat5 to these tyrosine residues of the PDGF beta-receptor.

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Further investigation with a similar approach is mandatory to obtain a firm conclusion. The effect of saliva on the formation of KOH-soluble fluoride after topical application of amine fluoride solutions of varying fluoride concentration and pH. Participants reported their images to be primarily visual, corresponding to the greater dual-task disruption observed for eye movements. The latencies of waves I and V decreased as a function of age at a rate of 0.01 and 0.05 ms/week during the neonatal period, 0.02 and 0.10 ms/month at 1-3 months and 0.014 and 0.076 ms/month at 3-12 months, respectively.

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Enriching the environment through the use of foraging devices has been one method and a study was designed to evaluate the short-term effect of a new foraging device on singly-housed cynomolgus monkeys. Magnetic resonance imaging revealed a cystic tumour in the right temporal lobe. EFFECT OF A DITHIOBIUREA DERIVATIVE ON SEMEN CHARACTERISTICS AND FERTILITY IN THE FOWL. No differences were found between the two groups in relation to dynamic compliance or resistance. Batch kinetics and isotherm studies were carried out to evaluate the effect of contact time, initial concentration, pH, presence of solvent, and the desorption characteristics of bentonite.

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Newsletters are marketed to physicians to provide a concise, accurate, and timely overview of the medical literature. In this review, hyposensitization or immunotherapy will be discussed.

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Assess capacity of health-care facilities in a low-resource setting to implement the absolute risk approach for assessment of cardiovascular risk in hypertensive patients and effective management of hypertension. In the non-infarcted regions, the mast cell density increased transiently to reach a maximum of 7 cells per mm2 on day 35 in the subepicardial layer.

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The level of expression of MHC class II, CD1, LFA-1 and LFA-3 was substantially increased over resting values 24 h after Fc gamma R occupancy. The rate of the non-directional transfer of cholesteryl ester and triglyceride by human cholesteryl ester transfer protein (CETP) was measured between human plasma lipoproteins by monitoring fluorescence spectrum of pyrene-labeled lipid. This study examined the impact of a research-derived, semistructured, bereavement support group among HIV-1-seropositive and HIV-1-seronegative homosexual men having lost a close friend or intimate partner to the acquired immunodeficiency syndrome within the prior 6 months.

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The study was conducted at an Ear Nose and Throat Department, University of Verona, Verona, Italy. Southern blot analysis of the lymph nodes showed a rearrangement in both patients of the Ig heavy chain gene and germ line configuration of the T cell receptor beta chain gene. Interestingly, the extent and kinetics of the mIg-associated Lyn and Ig-alpha/Ig-beta phosphorylation was correlated, suggesting that Lyn may mediate receptor phosphorylation. Experimental hyperthyroidism and vitamin B12 in the liver of rats Results confirmed that the right hemisphere (and particularly the posterior region) is critical for all of the main aspects of facial processing.

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An evaluation of a short-term chronic effluent toxicity test using sheepshead minnow (Cyprinodon variegatus) larvae. Physician adherence to key recommendations of guidelines for community-acquired pneumonia (CAP) is often not optimal. Specifically, this research aimed to elucidate the methods, processes, and outcomes related to the job performance of department chairs/division heads. The development of evidence based guidelines for clinical practice in oral health care has increased as well.

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Using reversed-phase HPLC combined with two independent anti-CRF radioimmunoassays, we have identified CRF in murine skin. True DPE I/O slopes decreased with level from a mean slope near 1.0 dB/dB at 30 dB SPL and below for all three f2 frequencies. Histologic types of gastric cancer according to the Lauren classification at the Cayetano Heredia National Hospital Excellent multiplexing capability of the DNA-AuP-RTag scheme was demonstrated by simultaneous identification of up to eight probes in a mixture.

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Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way. Semantic tasks, such as lexical decision making and word recognition, have not produced a mood priming effect.

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A similar combination of cytogenetic and molecular defects has been obtained earlier in the Bloom syndrome cells. In this work we present an improved solution for cardiac gating and ventilation timing in in vivo spectroscopic and imaging experiments. A PCR screen with two primer pairs in the rRNA region indicated that seven of the legume species were exclusively associated with strains having markers resembling Bradyrhizobium elkanii, while the remaining six host species harbored strains related to both B. berghei sporozoites, showed significantly higher IL-6 production by macrophages from both sources.

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A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors. The mechanisms leading to diabetic cardiomyopathy remain uncertain. Recognising faces: effects of lighting direction, inversion, and brightness reversal.

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This was supported by the fact that most of the injected MS existed pericellularly around the transgene-expressing cells. Inhibition of osteoblast-mediated mineralization is one of the major catabolic effects of parathyroid hormone (PTH) on bone. The effect of T-cadherin on angiogenesis in vivo was evaluated using Matrigel implant model. The measures described go beyond demonstrating a statistical association between some factor and disease or death, and attempt to assess, in real world terms, just how important a particular factor may be.

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Comparison of Legionella pneumophila isolates by arbitrarily primed PCR and pulsed-field gel electrophoresis: analysis from seven epidemic investigations. To evaluate the specific killing effects of the adenoviral vector in which the CD::UPP genes were directed by the MDR1 promoter on Taxol-resistance ovarian cancer cells in vitro and in vivo. In these model systems, an accelerated rate of de novo purine biosynthesis tended to be associated with an increase in cellular PP-ribose-P cotent, but decreases in this rate results from the reduction in the activity of amidophosphoribosyltransferase. Serum interleukin-6 (IL-6) increased with the increase in circulating ACTH and cortisol. Induction of micronuclei in the domestic cat (Felis domesticus) peripheral blood by colchicine and cytosine-arabinoside.

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Six animals were killed every two weeks up the end of the week 43. These results suggest that the fMRI BOLD response can reflect the processing of relative binocular disparity in extrastriate cortex.

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In fact, most genes have multiple promoters, within which there are multiple start sites, and alternative promoter usage generates diversity and complexity in the mammalian transcriptome and proteome. All extracts, except P122, caused proliferation of the estrogen-sensitive MCF-7-BUS cells. HLE-EPI and HLE-MIT overexpressed transporters MDR1/ABCB1 and BCRP/ABCG2, respectively.

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Prevention of femoral neck fractures in the Stovner district of Oslo Influence of antibiotics on infection in spinal surgery: a prospective study of 110 patients. The differentiation of prostatic fibroblasts into smooth muscle cells is regarded as the key step in the development of periurethral stromal nodules. Epstein-Barr virus (EBV)-determined characteristics in lymphoid cells. Analyzing diverse seismic catalogs, we have determined that the probability densities of the earthquake recurrence times for different spatial areas and magnitude ranges can be described by a unique universal distribution if the time is rescaled with the rate of seismic occurrence, which therefore fully governs seismicity.

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In both instances there were unilateral visual loss and unusual radiographic changes in the optic canal area. Reovirus type 2 (Reo-2) infection in DBA/1 sucking mice causes pancreatic islet-cell destruction, which results in a diabetes-like syndrome. SH3P7 migrates in sodium dodecyl sulfate-polyacrylamide gel electrophoresis as a 55-kDa protein that is preferentially expressed in brain, thymus, and spleen. THE EXPERIMENTAL REPORT OF CAUSE OF THE TOXEMIA IN LATE PREGNANCIES These results suggest that one of the products of PI(3)K, PtdIns(3,4,5)P(3), recruits WAVE2 to the polarized membrane and that this recruitment is essential for lamellipodium formation at the leading edge.

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Wound healing is a complex interchange, orchestrated between cellular components that play their respective parts signaled by and mediated by different cellular instruments of healing. The aim of the present study was to examine the expressions of mucin genes MUC1 and MUC4 and to evaluate the difference of their expressions in normal thyroid tissue, follicular adenoma, and papillary carcinoma. Sixteen patients developed recurrences involving the liver, only five of which were at the resection margin. In this paper, we present the initial results of using an optical CT scanner to evaluate a novel phantom in which radiation-exposed polymer gels are simulated by the addition of colloidal suspensions of varying turbidity.

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ISOLATION AND PREPARATION IN A PURE STATE OF THE ENZYME L-TYROSINE-HYDROXYLASE IMPORTANT IN ESSENTIAL HYPERTENSION Opening the sphere to provide both patient and surgeon access suggests cylindrical or biplanar magnets. This probe was used to clone the cDNA encoding HNG by screening a chronic granulocytic leukemia cDNA library. Experimental and control oligonucleotides were delivered directly into the amygdala just prior to electrical stimulation.

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Comparison of vessel response following sirolimus-eluting stent implantation as assessed by serial 3-D intravascular ultrasound study. In this review, we address the question as to whether endothelial cells in the CNS respond differently to specific cytokines known to induce either a proinflammatory effect or a regulatory effect in systemic vascular beds.

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There was no correlation with sex, education, cigarette smoking or alcohol consumption. Our data further demonstrate the immunomodulationinduced by virus infections and suggest that the detection of CL is an easily quantitated correlate of macrophage activation which may be helpful in defining metabolic alterations induced during activation. For treatment, we used a holmium:yttriumaluminum-garnet laser generator and a 200-microm flexible quartz fiber.

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Contextual modulation involves suppression and facilitation from the center and the surround. There is no consensus on the evaluated efficacy of individual alpha(1)-blockers in the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). From the National Institutes of Health: report of a workshop on respiratory syncytial virus and parainfluenza viruses. The structures of two dimers and one of the two trimers have been solved, while plausible models have been proposed for the structures of a second trimer and two tetrameric conformers. About half of the bovine testicular nerves are neuropeptide Y-immunoreactive.

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Results suggest that both online questionnaires were fairly equivalent to their paper-and-pencil versions, with higher reliability values for the SCL-90-R. Minimal binding proteins, such as Fab, scFv, and single variable domains are the preferred targeting elements for some investigational drugs, whereas non-immunoglobulin scaffold proteins have been explored as binding proteins in other designs.

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The glands of 10-14 weeks old foetuses are already able to react to glucose and respond to all other stimuli, except arginine. IL-1 alpha and granulocyte-macrophage colony-stimulating factor (GM-CSF) block the response of the LHRH terminals to NO. Electrophysiologic characteristics of an Andersen syndrome patient with KCNJ2 mutation. The phenotype is variable, and has been described in association with retinal dysplasia that can be stable or show progressive degeneration, retinal folds, lymphedema, and mental retardation. Once the animals are habituated, each trial should take approximately 1 min.