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Genoxal (Cyclophosphamide)
+ BONUS
 
Cyclophosphamide

Genoxal is a drug used to treat many types of cancer. It is also used to treat a certain type of kidney disease in children. It is also being studied in the treatment of cancer. Genoxal damages the cell’s DNA and may kill cancer cells. It may also lower the body’s immune response. Genoxal is a type of alkylating agent. Also called CTX.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Genoxal is used to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cell growth. Genoxal also works by decreasing your immune system's response to various diseases. It is used to treat a certain type of kidney disease in children after other treatments have not worked. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used for various conditions such as lupus and rheumatoid arthritis, and to prevent organ transplant rejection.

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The molecular mapping of receptors would give us not only a rationale for designing selective drugs, but also new insight about the genotype-phenotype relationships of a certain kinds of hereditary diseases caused by a mutation of receptor genes. Alterations in behavioural patterns which were expected a priori were observed but there appeared to be no changes in behaviour associated with any one selection criterion. In contrast, chemotherapeutic agents inadvertently induce NF-kappaB activity, which may lead to chemoresistance.

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Devices were retrieved after failure and analyzed by light microscopy and environmental scanning electron microscopy. Repair of DSBs by homologous recombination generally occurs by gene conversion resulting from transfer of information from an intact donor duplex to both ends of the break site of the broken chromosome. Many migrating animals employ a celestial compass mechanism for spatial navigation.

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The repA promoter has been located functionally by testing a series of repA:lacZ fusion plasmids. To evaluate composed long-leg images acquired with a large-area, flat-panel x-ray detector with regard to angle and distance measurements. Studies on the relationship between electrogustometry and sour taste perception. The purpose of this study was to assess the knowledge that parents of children with congenital cardiac disease have about bacterial endocarditis (EB) and its prophylaxis (PEB). Corneal angiogenic privilege: angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis).

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Recurrence of amyloidosis secondary to chronic infections in the renal allograft is highly unusual. These experiments indicate that naturally occurring sulfur-oxidising bacteria have the potential to break down Sulphlex paving material, resulting in adverse effects on both the structural integrity of the pavement and the local environment. Preoperatively, he suffered from dyspnea (NYHA class I-II) and angina pectoris (CCS class I-II).

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The use of PCO as a pre-treatment step for the enhancement of the biodegradability of wastewater, containing recalcitrant or inhibitory compounds is an alternative to a long and energy-intensive total pollutant mineralization. The physicochemical properties of propofol could allow diffusion across the alveolocapillary membrane and a measurable degree of pulmonary propofol elimination. Both activated and resting microglial cells release glutamate by the cystine-glutamate antiporter system xc-. In the fourth patient a less intensive, maintenance pulse therapy could not be continued due to unacceptable side effects. Synthesis and antiarrhythmic activity of 2,5-disubstituted 2,3-dihydro-1,2,5-benzothiadiazepin-4(5H)-one 1,1-dioxides.

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Cannabinoids excite hypothalamic melanin-concentrating hormone but inhibit hypocretin/orexin neurons: implications for cannabinoid actions on food intake and cognitive arousal. Estimation of the accident severity is a fundamental requirement in accident reconstruction and analysis. For RF patients, a part of the switch deficit could be accounted for by impaired inhibition of inappropriate responses or task-sets triggered by stimuli, and one measure of the switch cost correlated reliably with damage to the IFG, specifically the pars opercularis (POp).

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There was also indication of caspase-3-like activation, measured by immunoanalysis and biochemically. Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates. At our institution, patients who undergo coronary artery bypass grafting are now at greater preoperative risk at the time of hospital admission. Variant petrotympanic fissure as possible cause of an otologic complication during TMJ arthroscopy.

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They had a history of severe hyperbilirubinemia after birth as a result of Rh isoimmunization. In addition, we show that, despite its difference in receptor specificity, XFGF-3 can induce the formation of mesoderm from animal caps similarly to other FGFs. We have developed a cell culture model to study the possible relationships between purine salvage enzymes and immunologic function using an established T cell lymphosarcoma (S49) and a potent inhibitor of ADA, erythro-9(2-hydroxy-3-nonyl) adenine (EHNA). Comparison of DNA facilitators in the uptake and intracellular fate of infectious herpes simplex virus type 2 DNA.

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The relationship between family violence and teenage aggressiveness To investigate whether nine single-nucleotide polymorphisms (SNP) spanning the CYP19 gene were associated with AD. Intraoperative ultrasound (US) is a device which is a great help to neurosurgeon in intracerebral lesions localization, in the definition of inner tumors structure, in its relation to the surrounding structures, as well as during stereotaxic operations. Exit charge-state dependence of convoy-electron production in heavy-ion-solid collisions.

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To describe the attitudes of neonatologists to trial related perinatal postmortem examinations (PMs), in the light of declining perinatal PM rates and poor levels of participation in pathology studies. A novel uracil analog, 6-chloro-5-(2-propenyl)uracil, preferentially enhances growth inhibition and differentiation of myeloid leukemia cells induced by 1alpha,25-dihydroxyvitamin D3.

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Design and inhibitory properties of synthetic Bowman-Birk loops. Glutaraldehyde is considered a promoter of calcification by the action of toxic aldehyde group residuals from cross-linking. Bronchial obstruction was observed in eight cases, and of these, endobronchial disease was found in six children. Melanocytomalytic glaucoma in eyes with necrotic iris melanocytoma.

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The formation of intraneuronal inclusions is a common feature of neurodegenerative polyglutamine disorders, including Spinocerebellar ataxia type 3. Moving from the intensive therapy unit (ITU) to the ward environment can be a very stressful experience for patients. These findings suggest that eliminating pregnancy alcohol use might substantially reduce the risk of preterm delivery. The neoplasms observed in these mice have several similarities to tumors found in immunodeficient humans, suggesting that these mice may serve as useful animal models of lymphoma.

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To date, six flavin-containing monooxygenase (FMO) genes have been identified in humans, FMOs 1, 2, 3, 4 and 6, which are located within a cluster on chromosome 1, and FMO5, which is located outside the cluster. This defect in food intake regulation is partly based on the action of Takeout on taste neurons, because the sensitivity of to(1) gustatory neurons to sugars does not increase after starvation, as in wild-type neurons. The MVD may be hopefully used as an indicator of tumor malignancy. No catalytic hydrogen peak at -1.7 V appeared in the polarogram of plant and algae metal-binding substance, but did appear in the polarogram of the metal-chelating protein metallothionein. Observation of 174 domestic violence cases in a civil court indicated that the only significant factor related to case outcomes was the judge hearing the case.

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Diltiazem versus intravenous nitroglycerin in the treatment of unstable angina pectoris. These methods are rapid and simple to perform and will be useful for studying the epidemiology of P. CACS is a diagnosis of exclusion, characterized by the clinical triad of postprandial abdominal pain, weight loss, and vomiting. The aim of this study was to elucidate the neural pathway for sound-evoked myogenic potentials (SEMPs) in monkeys with characteristics similar to those of vestibular evoked myogenic potentials in humans. This suggests that differential timing of gene expression is not essential for proper storage of CR1 and that other sorting mechanisms are involved, which can be studied in RBL-transfectants.

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This decline has been accompanied by a commensurate fall in mortality in the same age range. Kynurenine, anthranilic acid, quinaldic acid, xanthurenic acid or 8-hydroxyquinaldic acid showed no effect on ECoG throughout the recording period of 4 hours. The hospital stay was remarkably shorter and less painful for the children operated on laparoscopically. No lymphatic vessels were detected in the zone of carbonization, they were mostly dilated whereas in the zone of edema. The possible pathological mechanism of tge disease and the therapeutic and diagnostic difficulties during this disease superimposed upon chronic glomerulonephritis are discussed.

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The spindle assembly checkpoint detects errors in kinetochore attachment to the spindle including insufficient microtubule occupancy and absence of tension across bi-oriented kinetochore pairs. Twenty volunteers were given single doses of fluoxetine 20 mg or an identical placebo daily for 28 days prior to receiving a single 10 mg oral dose of zolmitriptan. During the initiation phase of adipogenesis (day 4 to day 6), the expression of PPARgamma was induced and LY294002 blocked the increase of expression of PPARgamma mRNA. Clinical data from therapy with couples are presented in support of this premise.

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The literature concerning implicit memory presents conflicting evidence on the importance of meaning in recovering recently studied words. Other proton pump inhibitors have been shown to be effective in healing oesophagitis.

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Ewing sarcoma gene EWS encodes a putative RNA-binding protein with proposed roles in transcription and splicing, but its physiological role in vivo remains undefined. The aim of this study was to compare the effectiveness and safety of microdebrider-assisted inferior turbinoplasty (MAIT) with submucosal resection (SR) for children with hypertrophic inferior turbinates. Ten arthroscopic knee procedures were recorded on digital film with a frame rate of 25 images per second (almost 5 h in total). Vital role of moisture in the catalytic activity of supported gold nanoparticles.

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One novel gene with unknown functions was found and named as PS1TP5TP1 after being electronically spliced, and deposited in GenBank (accession number: DQ487761). Chromosomal localization of three human genes encoding members of the TGF-beta superfamily of type I serine/threonine kinase receptors. The thin filament associated protein h-caldesmon (h-CaD) modulates actin myosin interaction and contraction. This study compared the shear bond strength (SBS) to enamel of rest seats made with a glass-ionomer cement (Fuji IX GP Fast), a resin-modified glass-ionomer cement (Fuji II LC), and a composite resin (Z100 MP) under monotonic and cyclic loading.

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genetic, gonadal and phenotypic alterations, may result in different andrological problems, e.g. Defective and defective interfering RNAs of monopartite plus-strand RNA plant viruses. There is only limited research on the various legal regulations governing assessment, placement and treatment of mentally ill offenders in European Union member states (EU-member states). In this article, use of online information in our medical center is discussed, together with the impact of a locally-developed decision support system.

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A referral center and institutional practice, and outpatient care. The degree of expression of the tumor virus structural proteins in the transformed cells did not determine the cellular phenotype with regard to tumorigenicity in nude mice, nor did it modify the cellular growth properties in vitro. Here, we focus on the signal transduction pathways that are activated as a consequence of angiotensin II binding to the AT1 receptor. Of the 35 children positive at entry to the study 16 remained continuously positive, the others were negative on at least one occasion. In addition it is shown how the two- and three-bond H-D isotope effects upon carbonyl resonances may assist in their assignment.

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To clarify the identification of the type C viruses and their role in the genesis of the insulitis, type C virus specific antigens were identified within islet cells by immune fluorescence at various intervals after streptozotocin administration. Assessing child dental anxiety: the validity of clinical observations. In this population-based cohort, the presence of calcified carotid plaque, as assessed by high-resolution B-mode ultrasound, was an independent predictor of vascular events. It seems possible that down regulation of receptor activity develops independently of kindling but in response to long-lasting corazol application. The relation between summarizing variables of unstimulated serum TSH concentrations (25th, 50th, and 75th percentiles, the percentage of suppressed and unsuppressed TSH values) and risk for recurrence or thyroid carcinoma-related death was analyzed by Cox survival analyses in patients with at least four TSH measurements.

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Interdisciplinary diagnosis and therapy of traumatic optic nerve damage Adding a low-concentration heparin solution creates a suitable system for serial blood collection in the African green monkey for as long as 25 d. During EXT, the reinforcer maintaining problem behavior was withheld.

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The gene for synapsin III and attention-deficit hyperactivity disorder. Females, born LGA, have an increased risk to give birth to LGA infants, compared to mothers born not LGA.

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Plasma stability decreased to 22 h, however, sufficient enough not to play a major role in plasma half life. Effect sizes were consistently large, indicating that the diagnosis of ADHD at 4 to 6 years of age has predictive validity for both sexes. The proposed method can be adapted to other production activities in Mexico and to other countries. Nutritional requirements for infants, children and pregnant or breast-feeding women. The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women.

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Due to the high protein binding of this agent, PD parameters were calculated based on free drug exposures. The objective was to examine the effects of 2 dietary macronutrient patterns with different glycemic loads on adherence to a prescribed regimen of calorie restriction (CR), weight and fat loss, and related variables. We studied the potentiation of doxorubicin (DOX) activity in multidrug-resistant (MDR) cells by buthionine sulfoximine (BSO), a specific inhibitor of gamma-glutamylcysteine synthetase, and by cepharanthine (CE), which interacts with P-glycoprotein. Immunohistochemical distribution of RGS7 protein and cellular selectivity in colocalizing with Galphaq proteins in the adult rat brain. Detection and quantification of modified nucleotides in RNA using thin-layer chromatography.

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Selection of patients according to neuroimaging findings, and/or neurological sequela with documented perinatal antecedent. A review of advertisements for infectious diseases physicians in the 1990, 1993, and 1995 issues of the New England Journal of Medicine revealed a significant decline in the number of openings between 1990 and 1995. Randomised clinical trial of Hydrofiber dressing with silver versus povidone-iodine gauze in the management of open surgical and traumatic wounds. Advancements in ultrasound technology have allowed for delineation of specific ultrasonographic characteristics of breast masses and, as such, placement of these masses into categories based on their relative risk of malignancy. The effect of font size and type on reading performance with Arabic words in normally sighted and simulated cataract subjects.

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Fluidization of the lipid multilayers is believed to result in the loss of barrier properties of the stratum corneum. We characterized human BM ALDH(br) cells to determine whether cell sorting based on ALDH activity isolates potentially useful populations for cell therapy. The lack of circadian timing in two intertidal invertebrates and its significance in the circatidal/circalunidian debate.

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Efforts to identify children at risk for social and academic difficulties at an early age have begun to apply conceptualizations of social competence with peers from childhood to infancy and toddlerhood. This technique was applied to the isolation of three intron-exon junctions. Electrosynthesis of symmetric and highly conjugated benzofuran via a unique ECECCC electrochemical mechanism: evidence for predominance of electrochemical oxidation versus intramolecular cyclization. This study provides evidence for increased lipid peroxidation in serum but not CSF from MS patients, suggesting that either there is no increase in CSF lipid peroxidation in MS patients or that CSF lipid peroxides are rapidly removed, possibly by binding to CSF proteins that can be reabsorbed into the blood.

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Simultaneous determination of lansoprazole enantiomers and their metabolites in plasma by liquid chromatography with solid-phase extraction. Mosquito homolog of the La autoantigen binds to Sindbis virus RNA. Metal reinforced glass-ionomer cements are said to possess superior mechanical properties when compared to non-metal reinforced glass-ionomer cements. Structure and wavelength of the Cu K alpha 2 x-ray emission line. Nitric oxide and the haemodynamic profile of endotoxin shock in the conscious mouse.

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Avicenna system with 3 synthetic peptides as the test objects is characterized by a higher sensitivity and specificity and is recommended for practical use at blood service institutions. Activin receptor-like kinase (ALK)7 is a type I serine/threonine kinase receptor of the transforming growth factor (TGF)-beta family of proteins that has similar properties to other type I receptors when activated.

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These results prompt enquiry into the effect of spatial frequency at the single-cell level and place new constraints on image-processing models of early visual processing. Despite antibiotic therapy this led to an anterior mediastinal staphylococcal abscess, which was drained surgically and the patient recovered. Applicability of Abderhalden reaction in bacteriological technology In case of intolerance or inefficiency of corticosteroid therapy a treatment with synthetic ACTH either in combination with corticosteroids or only ACTH was applied to 23 patients.

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Anticonvulsants as anxiolytics, part 1: tiagabine and other anticonvulsants with actions on GABA. Chondrocytes remained rounded in the HA-MA hydrogels in vitro, and accumulated significant amounts of cartilaginous matrix. Visual and motor abilities were assessed using the Developmental test of motor integration (VMI) and the Movement ABC. It has been shown that it is possible to obtain a certain level of protection giving a good dose-effect relation. The effect was more potent than that of wild-type LPS as assessed by released LPS concentration and LPS induced cytokine syntheses.

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This enhanced agglutinability observed with cells maintained at the nonpermissive temperature for transformation may be related to the new set of low affinity receptors present at 41 degrees C. Pharmacokinetics and bioavailability of pentaerithrityl tetranitrate and two of its metabolites. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling.

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Polyglandular activation of autoimmnunity as a manifestation of subclinical endocrinopathies Hemoglobin-based oxygen carriers have many characteristics that would serve as a useful adjunct to red cells in clinical settings.

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The Washington Department of Health (WDH) monitors DKA-associated hospitalizations to assist its chronic disease programs in preventing DKA-associated hospitalizations and deaths. The peak force recorded was significantly less for laminated EVA samples with a Sorbothane intermediate layer than for controls of comparable thickness. The Magneto Immuno-PCR (M-IPCR) is based on antibody-functionalized biogenic magnetosome nanoparticles revealing major advantages over synthetic magnetic particles. Doctor and practice characteristics associated with differences in patient evaluations of general practice.

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Panel subgroups developed and discussed different sections of the report before discussing them with the entire panel. Setting the pace for VISION 2020 in Ghana: the case of Bawku Eye Care Programme. CK2 inhibitors could promote an increased uptake of chemotherapeutic drugs inside the cells and sensitize them to drug-induced apoptosis in a co-operative manner. Outcome of cardiopulmonary resuscitation norvasc side effects 2.5 mg in the intensive care setting.

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This technique, along with examination of the eyes and optic nerves, will optimally identify the injuries associated with shaking injuries. No point mutation within the alpha PKC gene, previously thought to be associated with invasive pituitary tumors, was found in any of the 20 farmapram alprazolam effects somatotrophinomas. This study investigated the value of oral alendronate for treating OI in Indian children. Absence of lipolytic action of adrenaline on a human subcutaneous adipose tissue. Osteomatous chronic otitis media is an extremely rare clinical entity.

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Collagen synthesis and the activities of prolyl hydroxylase, lysyl hydroxylase, collagen galactosyltransferase and collagen glucosyltransferase were studied in isolated chick-embryo tendon cells after the administration of cortisol acetate to the chick embryos. In addition, lead did not have any buy zanprol 10mg tablets omeprazole toxic effects on plants in sand-perlite mixture at 500 mg l(-1), whereas cadmium showed toxic effect even at such low concentrations as 50 mg l(-1).

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Dependence oxcarbazepine side effects in pregnancy of sympathetic vasomotor tone on bilateral inputs from the rostral ventrolateral medulla in the rabbit: role of baroreceptor reflexes. Furthermore, we observed that inhibition of GSK-3 leads to a decrease in NFkappaB-mediated gene transcription but does not affect the nuclear accumulation of NFkappaB in CLL B cells. Computerized searches were conducted of multiple bibliographic electronic databases from their inception until May 2006. Finally, the usefulness of alternative methods of education such as self-learning packets is examined by cost analysis.

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Rapid response after massive air entry into the left ventricular assist device system, as in our patient, can result in a successful outcome. Plethysmography was used to measure forearm resting vascular resistance (Rrest) and minimum vascular resistance (Rmin) as cleocin generic price a measure of vascular structure.

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Simulations show that the proposed approach can be implemented efficiently and that it outperforms mesyrel trazodone withdrawal previous methods by more than 2 dB. Stark broadening and regularities of prominent spectral lines of multiply ionized chlorine and fluorine. coli isolates from both water and sediment samples supported the hypothesis that cattle and wildlife were dominant sources of fecal contamination, with minor contributions by horses and humans. Specific findings from the surveys indicated the desirability of establishing training sequences consisting of rotating podiatric residencies followed by specialty training programs but identified significant difficulties related to implementation.

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Preparation and evaluation of tobacco seed oil-modified alkyd resins. Alternatively, these five hormones caused increased levels of fibrinolytic proteins (tissue plasminogen activator) and endogenous anticoagulants (protein C antigen and activity). Hereditary pancreatitis (OMIM 167800) is thought to be associated clonac 50 tablets side effects with a mutation of the exon 3 of cationic trypsinogen (Nature Genet (1996): 14:141-145). The efficacy of two methods of Langerhans islets immunoisolation was compared.

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