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A number of studies have shown that a high proportion of aerosolized medications delivered by metered dose inhalers (MDIs) and aqueous spray devices deposits in the anterior one-third of the nasal cavity. (d) Strains with double mutations at positions 264 and 255 display a downshift of the B-band peak temperature. There were small lesions of viable metastatic cells in the tumor histologically.

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The relationship between structure (crystallin distribution) and function (refractive index) in the lens is not understood and can be studied by comparing biochemical and optical properties. Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan. The results indicate high levels of price variability, widespread disregard for average cost pricing rules and some indication that competition had some effect on prices. Voided urine samples were obtained from each patient for immunocytology and cytopathology. This conditional evaluation is based on the well-known Mantel-Haenszel statistic.

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Five of 13 clonal cell lines containing mixtures of wild-type and mutant mtDNAs were found to undergo a rapid shift of their genotype toward the pure mutant type. Neurite branching pattern formation: modeling and computer simulation. Oxytocin-stimulated release of prostaglandin F2alpha from ovine endometrium in vitro: correlation with estrous cycle and oxytocin-receptor binding.

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A case of fracture of the os humeri, in which the broken ends of the bone not uniting in the usual manner, a cure was effected by means of a seton. Investigation of hospital-acquired infections due to Alcaligenes denitrificans subsp. Examination of the ornithine decarboxylase (ODC) activity of recombinant human IL-1 alpha treated cells showed that all the sensitive but none of the resistant cell lines could down-regulate their ODC activity.

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The results are considered to give some support to the hypothesis that adaptive changes in the mitochondrial calcium transport cycle in skeletal muscle occur during acclimation to cold. 70 women without a specific autoimmune disease, using criteria of the American College of Rheumatology, but who had silicone breast implants were studied for the presence of serum antibodies to native and denatured human types I and II collagen by ELISA. This paper presents a review of five paradigm presentations at the first International Conference on Improving Use of Medicines (ICIUM) in Chiang Mai, Thailand, April 1-4, 1997. The combined infusion of glucagon (0.5 microgram/kg/min) with theophylline (0.1 mg/kg/min) increased renin secretion markedly, although it produced renal hemodynamic changes similar to those induced by glucagon alone.

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While myopathy has generated considerable interest, mild musculo-skeletal symptoms are poorly assessed. Primary bone lymphoma: a new and detailed characterization of 28 patients in a single-institution study. Acquired ataxias, due to congenital cytomegalovirus infection or perinatal problems, form a small third group. Proliferating corneal endothelial cells covered the wound area up to the uveal part of the trabecular region.

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To identify proteins that interact with ERK7, we utilized a yeast two-hybrid screen with the COOH-terminal tail of ERK7 as bait and isolated the cDNA for a novel protein termed CLIC3. The analysis of culture filtrate concentrates by means of SDS-polyacrylamide gel electrophoresis and fluorography revealed a similar and complex electrophoretic pattern, though some qualitative and quantitative differences between samples obtained from yeast and mycelial cells were observed. Inflammatory cytokines and cytokine antagonists in whole blood cultures of patients with systemic juvenile chronic arthritis.

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The injection of adrenocorticotropic hormone (ACTH) of prolonged effect at the doses of 4 and 10 M. Twenty years of recombinant human growth hormone in children: relevance to pediatric care providers. Upward trend in tobacco use, particularly in women, is a reason for concern. From NMR studies and molecular modelling, we present structures for the two conformers and conclude that they have different binding affinities for cell wall analogues. We conclude that because of the unique geometry of alveolated duct and its time-dependent motion associated with tidal breathing, chaotic flow and chaotic mixing can occur in the lung periphery.

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Staff opinions regarding the Newborn Individualized Developmental Care and Assessment Program (NIDCAP). Clearance of minimal residual disease after allogeneic stem cell transplantation and the prediction of the clinical outcome of adult patients with high-risk acute lymphoblastic leukemia.

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Temporal hypoactivity was seen 1 min after administration in the 50 mg/kg group. The results showed that bovine lens extracts contain protease activity that can cleave. Antioxidants modulate the IL-6 induced inhibition of negative acute-phase protein secretion in HepG2 cells. These results suggested that peritoneal cells are required in the induction of antibody-dependent cytolysis in vivo.

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The adsorption process is primarily based on electrostatic interactions, which could be demonstrated by a significantly higher adsorption rate and binding capacity for lipid A-diphosphoryl, compared with lipid A-monophosphoryl. The phases of the circadian rhythm exhibit 1-year period variations, while those of the circannual rhythm exhibit 1-day period variations. The quantity of GA3ox1 transcripts increased during dormancy relief in all conditions, in particular when dormancy relief was completed by exposure to light. Human EC were exposed to human whole blood thrombus for 2, 6, 12, and 24 h. Previous results utilizing the Morris water maze task have shown that prenatal, or early postnatal, exposure to ethanol produces deficits in the use of spatial memory, a type of memory that is dependent on an intact hippocampus.

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There were no abnormal blood chemical or hormone data except at end stage. The primary cells in culture are multiangular or irregular, and the confluent trabecular cells grow as a single cell layer. The expression of VEGF could be down-regulated by silencing the iNOS gene in Tca8113 cells. A comprehensive drug screening was carried out in plasma or urine, or both, of 310 patients combining an HPLC multidrug profiling system and a fluorescence polarisation immunoassay. Mineral water cures for the wounded and social security organization

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The DEAE-cellulose chromatography of the last tumor showed a loss of isoenzyme II. Covariates of prognostic significance were treatment, initial performance status and sex. Hydraulic conductance (L(0)) increased in ryegrass with increasing ammonium doses but no change due to the nitrogen source was observed in water potential (Psi(w)) values. To review methodological issues and available data regarding the prevalence of psychiatric disorders in HIV-positive people over the age of 50 years.

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Thus, Gly15 in the HTH motif of BstHU has an important role in the thermostability of BstHU. To audit non-attendance rates at ENT out-patient clinics following the introduction of a text reminder system. Therefore, multiple mechanisms are involved in the proper targeting of Akt during the early events of T cell activation.

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Expression of MR mRNA was significantly decreased in all subregions of the hippocampus except CA2, but 6-OHDA lesions had no effect on GR mRNA expression. In contrast, Glis3 expression inhibits adipocyte differentiation. In order to determine the precise composition of the Mediator complex and to explore the specific role of each Mediator protein, our goal was to identify all of the Mediator components. These data demonstrate that the reversible P2Y(12) receptor antagonist, BX 667, has a wider therapeutic index than clopidogrel in experimental models of thrombosis. Age-adjusted mortality rates for asthma and chronic bronchitis were calculated from 1980 through 1989 for all age groups.

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Thrombosis of the internal jugular vein is now rare but was well-known in the pre-antibiotic era, when it was associated with fulminant infections of the head and neck. Radiographic findings were correlated with the pathologic specimens from suction rectal biopsy. Aesthetic management of the breast following explantation: evaluation and mastopexy options. At all vaccine dosages, there was a significant antibody-response difference between the genetic lines at 6 and 10 d postvaccination.

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Patients who have more severe forms of rheumatic disease, take higher doses of NSAIDs with steroids and suffer concomitant medical illness are at higher risk for these toxicities. In the case of triples and partition indices, these subsets correspond to binary partitions containing some clusters, while in the cluster index, a novel dissimilarity method introduced in this paper, the subsets are exclusively clusters. Small for gestational age (SGA) infants who were treated with fewer days of antibiotics characterized the fulminant sepsis group.

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Analysis of some of these genes has yielded important information on processes such as patterned secondary cell wall deposition. In-silico analysis and high-throughput cloning and expression have had major impacts on efforts to develop vaccine candidates and diagnostic reagents.

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Reduction in the level of sICAM-1 after the treatment may be related to the decreased inflammation in response to therapy. Industrial emissions cause extreme urban ozone diurnal variability. A transesophageal echocardiography probe causes airway obstruction in an older child.

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Investigation of associations of reactive arthritis (ReA) with histocompatibility antigens class I and II and determination of new approaches to assessment of association ReA with antigen HLA B27. Thus, this complex has the potential to help translate the potent effects of siRNA into a clinically viable anticancer therapeutic. CLINICAL AND HISTOPATHOLOGIC CONTRIBUTION TO THE KNOWLEDGE OF BENIGN RETICULOENDOTHELIOSIS

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The new national smokefree law resulted in increased quitting-related behaviour. Development of medical genetics in the Czech Republic from 1986 to 1990. This is the first report on the application of real-time RT-PCR for detection as well as quantitation of JEV from patient CSF samples.

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Doppler sonographic monitoring control of perfusion of hepatocellular carcinoma after arterial chemoembolization The relationship between illness severity and neuroanatomical abnormalities in schizophrenia remains unclear. Ethics of placebo-controlled trials of zidovudine to prevent the perinatal transmission of HIV in the Third World.

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peptides composed of the same amino acids as MAP but in a scrambled sequence) failed to increase incorporation. Lymphocyte ultrastructure in two cases of neuronal ceroid-lipofuscinosis. Overexpression of hMTH1 mRNA: a molecular marker of oxidative stress in lung cancer cells. We measured levels of S100 beta nuclear primary transcript to assess whether alterations in transcriptional rate explain the changes in messenger RNA. These data may have implications for the design of new-generation AAV vectors.

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Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice. We have fabricated gold microelectrode arrays on a silicon dioxide substrate that supports long term, robust growth of the cells at room temperature and under ambient atmospheric conditions. Estimated and predicted changes in the cat population of Australian households from 1979 to 2005. Hence, the standard learning tools of DBNs can be applied in the context of PBNs, and the inference methods give a natural way of handling the missing values in PBNs which are often present in gene expression measurements. The compounds are structurally closely related to jaspamide/jasplakinolide from marine sponges of the genus Jaspis.

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By identifying and counseling substance abusers within their own practices, primary care physicians can play a major role in reducing levels of substance abuse. Other diseases showing airway hyperresponsiveness, such as allergic bronchopulmonary aspergillosis, Churg-Strauss syndrome, and left heart failure presenting cardiac asthma, may sometimes show similar clinical pictures to COPD.

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Finite-basis-set approach to the Dirac equation for atoms in a Dirac-Fock-Slater potential. A case of poisoning with ethyl fluoroacetate is presented in detail. A layer-peeling inverse-scattering algorithm is used to produce an initial solution, which is optimized numerically with an iterative optimization method.

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Fifty-seven eyes were randomized to receive standard PRP (19 eyes), selective PRP (20 eyes), or PDT (17 eyes). We investigated the expression of UP genes in the tissues and peripheral blood of patients with TCCs. 9-Hydroxyellipticine inhibits telomerase activity in human pancreatic cancer cells. They contrast strikingly with the profound deficits in hippocampus-dependent, short-term, flexible spatial working memory observed in these knockout mice. We use a novel approach to determine the temporal development of cyclin B1-Cdk1 activity in single cells.

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The most remarkable feature of these results is that they were obtained using a purely feed-forward neural network in which none of the neurones fired more than one spike (thus ruling out conventional rate coding mechanisms). Recently, the protein kinase PKB/akt (referred to here as PKB) has been identified as a downstream target of PI3K necessary for survival. Effect of osteoarticular tuberculosis on diseases of the urinary tract (diagnostic and therapeutic difficulties)

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The first part of the paper addresses some features of process manufacturing and their influence on production scheduling. However, this procedure raises questions concerning the effects of mother-infant separation itself on neurotoxicity endpoints. Surface-enhanced laser desorption/ionization-time of flight revealed that many peaks were induced or repressed following stimulation with R1881 or estradiol. Thus, compounds that modulate the metabolic activation of NNK can be potent inhibitors of NNK tumorigenesis. A1 adenosine receptor antagonism improves glucose tolerance in Zucker rats.

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PRESENCE OF GLUCOSAMINIDASE ACTIVITY IN HUMAN SYNOVIAL FLUID AND ITS INHIBITION BY GOLD COMPOUNDS. Mutation analysis by a non-radioactive single-strand conformation polymorphism assay in nine families with X-linked severe combined immunodeficiency (SCIDX1). In addition, to clarify the mechanisms responsible for the activation, we examined the biochemical changes in dying vascular smooth muscle cell (VSMC) and the effects of various molecules to the receptor-mediated VSMC death.

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These models were each examined for mammary-tumor expression of AR and CR-1 by reverse transcription-polymerase chain reaction, western blot, and immunocytochemical analyses. In the present work, multicellular spheroids from 4 human glioma cell lines (U-373Mg, A-172Mg, U-251Mg and HF-66) were confronted with normal rat brain cell aggregates in vitro, which resulted in a progressive invasion of tumor cells into the brain aggregates. Cyproheptadine blocked the potentiating effect of benzodiazepines on the head twitches induced by both 5-HT (i.c.) and mescaline. Retrospective data suggest that it might improve survival in cancer patients. Vectorcardiographic parameters were more influenced by the anthropometric parameters then by age.

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The secretion of the gp43 as a function of the growth curve, its partial aggregation with a proteolytic enzyme, ability to bind laminin, as well as to form circulating immunocomplexes in vivo could play a role in pathogenesis. Some are produced in endocrine glands and circulate as hormones, while others are contained in cardiac myocytes, neurons, or endothelial cells in proximity to the sinoatrial node and can therefore act in a paracrine or autocrine way on the pacemaker cells to modulate heart frequency. This makes niacin ideal for treating a wide variety of lipid disorders, including the metabolic syndrome, diabetes mellitus, isolated low high-density lipoprotein cholesterol, and hypertriglyceridemia. Using an enzyme-linked immunosorbent assay we demonstrate that the monomeric domain binds to specific phosphotyrosine peptides.

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The effects of tripeptide corticoliberin fragment CRF4-6 (Pro-Pro-Ile) on blood glucose level and the rat body temperatire were investigated. As an expression of the dynamic balance between fibrinogenesis and fibrinolysis plasminogen is activated either by proteases deriving from the blood clotting cascade or by its linkage to the kallikrein kinin system. The characteristics of the forward hot electrons produced by subpicosecond laser-plasma interactions are studied for different laser polarizations at laser intensities from subrelativistic to relativistic.

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Mechanisms of glucagon-induced renal vasodilation: role of prostaglandins and endothelium-derived relaxing factor. In the absence of treatment of pulmonary lesions fistulae can develop. Potentials and limitations of color M-Mode and tissue Doppler indexes in identifying pseudonormal mitral filling pattern in patients with acute symptoms of heart failure and preserved left ventricular systolic function. ovis DnaK protein could behave as a functional heat shock protein in E. We included studies that compared elective caesarean section to vaginal or intended vaginal delivery, with clear definition of outcome measures and information about gestational age.

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