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Herpesil (Acyclovir)
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Acyclovir

Herpesil is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein-Barr virus infection. It can be taken by mouth, applied as a cream, or injected.Common side effects include nausea and diarrhea. Potentially serious side effects include kidney problems and low platelets. Greater care is recommended in those with poor liver or kidney function. It is generally considered safe for use in pregnancy with no harm having been observed. It appears to be safe during breastfeeding. Herpesil is a nucleoside analogue that mimics guanosine. It works by decreasing the production of the virus's DNA.Herpesil was patented in 1974, and approved for medical use in 1981. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. It is available as a generic medication and is marketed under many brand names worldwide. The wholesale cost as of 2014 to 2016 was between US$0.03 and US$0.12 for a typical dose by mouth. The cost of a typical course of treatment in the United States is less than US$25. In 2016 it was the 195th most prescribed medication in the United States with more than 3 million prescriptions.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Herpesil is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and first-time or repeat outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and rectum from time to time). Herpesil is also sometimes used to prevent outbreaks of genital herpes in people who are infected with the virus. Herpesil is in a class of antiviral medications called synthetic nucleoside analogues. It works by stopping the spread of the herpes virus in the body. Herpesil will not cure genital herpes and may not stop the spread of genital herpes to other people.

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It contains an aspartame-like site which is formed by Asp21 and Phe80, tips of the two extruding loops KGDAALDAGGR19-29 and CKRFGRPP77-84, which are spatially positioned next to each other. When a hospital is considering whether to expand or transform its approach to outpatient surgery business, its internal financial and operating reports can help clarify trends and provide insight into the performance of the existing business over time. We used a novel paradigm-based on the saccade-countermanding task-as a tool to investigate rhythm saccade pacing and to provide information on the mechanisms of predictive timing. The increasing use of magnetic resonance imaging in the diagnosis of musculoskeletal injuries has alerted clinicians to the phenomenon of bone bruising.

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Cryptic carbapenem antibiotic production genes are widespread in Erwinia carotovora: facile trans activation by the carR transcriptional regulator. Since the introduction of highly active antiretroviral therapy (HAART), the incidence of death in HIV-infected patients has dramatically decreased, and causes of death other than those related to HIV infection have increased, although it is unclear how these parameters compare with those in the age-matched general population living in the same geographical region. Epidemiological and virological investigation of respiratory virus diseases in a county of Romania, 1970--1974. In contrast to earlier results, this study did not reveal occurrence of cyst-like spaces in the white matter of cerebellum using either perfusion or immersion tissue fixation techniques. Marked systemic hypotension depresses coronary thrombolysis induced by intracoronary administration of recombinant tissue-type plasminogen activator.

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Hypoperfusion as demonstrated by SPECT rCBF studies may play an important role in the pathophysiology of mental disorders, i.e., postoperative delirium. The present study was carried out to evaluate whether there is a difference in the binding of bilirubin to the erythrocytes from healthy smokers and non-smokers.

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The study was designed as a double-blind, placebo-controlled, cross-over clinical trial. An initiation zone of chromosomal DNA replication at the chicken lysozyme gene locus. Maximum likelihood estimation is carried out using Gauss-Hermite integration and a standard Newton-Raphson procedure.

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In situ hybridization for mRNA detection in Arabidopsis tissue sections. We previously demonstrated that the human lymphoblastoid B-cell line (LCL) TOFE, derived from normal human bone marrow, is permissive to HCV infection. Excitation of the hydrogen atom by fast-electron impact in the presence of a laser field. Although a live-attenuated vaccine protects against measles virus (MV), a member of the paramyxovirus family, the virus remains a principal cause of worldwide mortality and accounts for approximately 21 million cases and 300,000 to 400,000 deaths annually.

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Department of Ophthalmology at the Tulane University Health Sciences Center, between June 2001 - July 2002. Uptake of gp120 to trophoblast is by a high capacity, CD4-independent mechanism that is probably nonspecific and may be related to the mechanism for binding other circulating glycoproteins in maternal blood. To this aim, we analyzed the influence of TLE and proactive interference (PI) on immediate and 24-h long-term recency effects during face recognition in 16 healthy participants and 18 right and 21 left non-surgical TLE patients. The blood-aqueous barrier in eyes with pseudoexfoliation syndrome. In this paper, we are concerned with cost reduction, operating suite utilization, and capacity planning in surgical services.

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Selection of strains capable of utilizing D-xylose and cellobiose to produce ethanol by electric field-induced protoplast fusion. This is the first case in which the histopathologic findings are described in enough detail to suggest a pathogenic relationship between the two diseases. As single agents, both paclitaxel and epirubicin in combination with cytokines can mobilize peripheral blood progenitor cells (PBPCs).

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H-ICSBP is expressed exclusively in cell lines of hematopoietic origin. These results support a role for rab17 in regulating traffic through the apical recycling endosome, suggesting a function in polarized sorting in epithelial cells.

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Efficient production and secretion of bovine beta-lactoglobulin by Lactobacillus casei. Measurement of thrombomodulin values in the serum and eyes of experimental autoimmune uveoretinitis The delivery of angiogenic factors to the heart by microsphere therapy. Islets harvested from Nile tilapia (Oreochromis niloticus), when transplanted into streptozotocin-diabetic nude mice, produce long-term normoglycemia and achieve mammalian-like glucose tolerance profiles.

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All patients undergoing primary CEA performed by a vascular surgeon (BMB) between 30 May and 11 November 1996. All the benefits provided by an association may not necessarily attract members and the philosophical differences between them are one of the reasons not join an association. The mode of action of 2-(thiazol-2-ylthio)-1beta-methylcarbapenems against Pseudomonas aeruginosa: the impact of outer membrane permeability and the contribution of MexAB-OprM efflux system. Melanosomes in sporadic dysplastic nevi were examined by transmission electron microscope.

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Inhibitory effects of plant tannins on ultraviolet light-induced epidermal DNA synthesis in hairless mice. By monitoring the nucleotide-bound form of RAP1A protein, we established that the various protein localizations were related to the GTP/GDP-bound state. Cardiac manifestations of Anderson-Fabry disease: results from the international Fabry outcome survey. Arterial blood gas analysis during and after surgery demonstrated a large alveolar-arterial gradient for oxygen in the absence of any obvious pulmonary pathology while the patient was receiving positive pressure ventilation (PPV).

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Pyomyositis due to Mycobacterium haemophilum in a patient with polymyositis and long-term steroid use. Diurnal variations of tumor necrosis factor alpha mRNA and alpha-tubulin mRNA in rat brain. SSCP analysis was abnormal only in the case with positive immunostaining and localized the mutation to exons 7 and 8. Remarkably, TRAF2-DN overexpression, which was found to inhibit the TNF-dependent recruitment of endogenous wild-type TRAF2 to the TNF-R75 signaling complex, could neither block TNF-R55- or TNF-R75-induced NF-kappaB activation nor granulocyte/macrophage-CSF secretion. The myofibroblasts have previously been found to be abundant in breast cancer tissue.

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We aimed to develop an approach with which to quantitatively assess prognostically pertinent aspects of metabolic asymmetry in presurgical PET scans for forecasting postsurgical seizure-free clinical outcomes. Together, the two founding members of the FF family execute the majority of cell-cell fusion events in C. Importantly, large quantities of dendritic cells (DCs) of several subtypes are obtained (up to 8 million per overnight collection), as well as many other trafficking leukocytes.

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A consensus has emerged for performing bilateral removal of the ovaries after the age of fifty in the absence of a history of pelvic adhesions and/or endometriosis. Furthermore, these predictive relationships appeared only among individuals not involved in additional treatment.

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Background adaptation reduces the deduced rate of rise of phosphodiesterase activity. To determine the outcome of displaced talar neck fractures at long-term follow-up in terms of functional outcome and secondary reconstructive surgery. A novel mutation of the beta-glucocerebrosidase gene associated with neurologic manifestations in three sibs.

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Autopsy examination showed a poorly demarcated astrocytoma in the sylvian fissure infiltrating the adjacent subarachnoid space. Towards developing HIV-2 lentivirus-based retroviral vectors for gene therapy: dual gene expression in the context of HIV-2 LTR and Tat. Attachment of encephalomyocarditis virus and permissiveness of cultured pancreatic beta cells to infection. The classical pharmacological methodology using phenylephrine and sodium nitroprusside was used to trigger blood pressure changes, and the resulting alterations in heart rate were analysed quantitatively using a logistic function. The cytotoxicity of this procedure was determined with a colorimetric ELISA with Alamar blue.

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In directing the synthesis of RNA through the intervening DNA and the gene by a tracking and transcription mechanism, the HS2 enhancer may (i) open up the chromatin structure of a gene domain and (ii) deliver enhancer binding proteins to the promoter sequence where they may stimulate the transcription of the gene at the cap site. Analysis and computer simulation of aerobic oxidation of reduced nicotinamide adenine dinucleotide catalyzed by horseradish peroxidase. The fever was markedly suppressed when the rats had been pretreated with a cyclooxygenase-2-specific inhibitor. Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro. After surgical drainage and intravenous antibiotic treatment the boy recovered without complications.

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Although most cells accomplish this by activating telomerase, a subset of immortalized tumors and cell lines do so in a telomerase-independent manner, a process called alternative lengthening of telomeres (ALT). An ergosterol auxotroph, erg25, which fails to demethylate and concomitantly accumulates 4,4-dimethylzy-mosterol, was isolated after mutagenesis. Inappropriate models may give totally misleading information which cannot be extrapolated to human cancers. A role of paracoccin on the cell wall organization was reinforced by alterations in the labeling pattern of chitin when yeasts were treated with anti-paracoccin antibodies.

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Whether malignant tumors develop on benign adenomas or are malignant from onset is still not known. In an attempt to select HIV strains that can overcome the inhibition, we now have used T-cell lines that stably express a C-terminal fragment of LEDGF/p75. In addition, some general comments are made about several special injuries for which burn center referral usually is sought.

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We also showed that N protein activated IL-6 expression through NF-kappaB by facilitating the translocation of NF-kappaB from cytosol to nucleus. In contrast, von Willebrand factor (VWF) and vascular cell adhesion molecule-1 (VCAM-1) were expressed equally by the vascular arrays and by stromal fibroblastic cells. The molecular approach which is just emerging in this particular research area will greatly improve our knowledge.

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Modulation of the biosynthetic pathway, still not fully understood, of dolichyl phosphate may also be an important factor. Due to the resurgence of tuberculosis and the emergence of multidrug-resistant strains, fluoroquinolones (FQ) are being used in selected tuberculosis patients, but FQ-resistant strains of Mycobacterium tuberculosis have rapidly begun to appear. Cytogenetic analysis of prostate carcinoma by fluorescence in situ hybridization. The study demonstrates that application of an occlusive dressing or paper patch in 30 per cent of patients can promote the healing of long-standing perforations.

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Two residues, Asp 951 and His 915, were shown to be catalytically crucial by site-directed mutagenesis and subsequent characterization of purified mutant proteins. The removal of serum from the medium of uninfected fibroblasts decreased the rate of uptake of uridine, 2-deoxyglucose, alpha-aminoisobutyrate and thymidine. We also measured stress and determined if higher stress level was associated with disclosure or nondisclosure.

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The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. The simultaneous release by bone explants in culture and the parallel activation of procollagenase and of a latent neutral proteinase that degrades cartilage proteoglycans and denatured collagen. This article reports two new techniques of connecting ascending to descending aorta using an intrathoracic conduit and performed through a median sternotomy.

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Histopathologic findings in women with postmenopausal bleeding: implication for endometrial thickness and circulating levels of sex steroid hormones. An RF excitation technique with which one can improve the effective dynamic range of the receiver and reduce the interference between slices for 3D volume-selective multislice MRI is described.

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We present the results of a national survey carried out in 1997 among French ophthalmologists on prophylactic antibiotic and antiseptic therapy in cataract surgery. Expression of 140-kDa neural cell adhesion molecule in developing testes in vivo and in long-term Sertoli cell-gonocyte cocultures.

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The apparent Michaelis constant was on the average found to be 100 times lower than for some single-stranded DNAs previously studied. Cells preinduced to synthesize collagenase did not produce the enzyme when collagen was removed from the culture medium. At 30 degrees C, organic acids were preferentially utilized during the first growth phase. Under these conditions, HIV-drug resistance development could be prevented, and progression to AIDS, arrested.

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When the autoimmune serum was used in the immuno-gold procedure for electron microscopy, gold particles were found only on the sperm nucleus. Although the p53 steady-state levels are elevated throughout the infection, evidence suggests that the ability of p53 to transactivate some of its downstream targets is compromised.

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Update on the contribution of galactomannan for the diagnosis of invasive aspergillosis. Fenton reagents may not initiate lipid peroxidation in an emulsified linoleic acid model system. Instillation of normal saline before suctioning has an adverse effect on oxygen saturation and should antibiotics chloromycetin sodium not be used routinely in patients receiving mechanical ventilation who have pulmonary infection. Differential activation of the rice sucrose nonfermenting1-related protein kinase2 family by hyperosmotic stress and abscisic acid. Eleven divers completed two series of chamber dives according to the decompression schedule of the Professional Association of Diving Instructors.

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