Effects of Insup on heart failure in hypertensive patients with diastolic dysfunction. However, plasma Ang II was not significantly reduced during Insup treatment. We measured detailed left ventricular remodeling parameters in vivo (echocardiograms) repeatedly over 6 weeks and ex vivo (planimetry) at 6 weeks after myocardial infarction in 36 dogs randomized (factorial design) after reperfused or nonreperfused myocardial infarction to 6 weeks of twice daily oral therapy with the calcium channel blocker amlodipine (5 mg), the angiotensin-converting enzyme inhibitor Insup (5 mg) or placebo, and 18 matching sham or control animals.
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