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Adiponectin, an adipose tissue-specific plasma protein, has been shown to ameliorate insulin resistance and inhibit the process of atherosclerosis. Concentrations giving half-maximal effects were 5, 5, and 200 microM for cysteine, CysGly, and gammaGluCys, respectively. Topical medications are an alternative approach to deliver high concentrations to the mucosa while limiting systemic side effects.

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Phenobarbitone (12mg/kg, i.p.) and diazepam (0.5mg/kg, i.p.) effectively antagonized only seizures induced by PTZ (95mg/kg, i.p.), bicuculline (40mg/kg, i.p.) and picrotoxin (12mg/kg, i.p.). The findings have implications for understanding the mechanisms involved in the development of schizophrenia and, possibly, for its prevention. Multivessel coronary thrombosis treated with abciximab (ReoPro) in a patient with essential thrombocythemia. All patients were men and the granulomas developed in their trunk.

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They were bounded by a single trilaminar membrane and contained closely packed membranes in concentric, curved or parallel arrays. Ethics of placebo-controlled trials of zidovudine to prevent the perinatal transmission of HIV in the Third World. Morphology and histochemistry of the glandular trichomes of Lippia scaberrima (Verbenaceae). A reduction of the apolipoprotein ratio CII/CIII occurred after the acute phase.

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No amastigotes were seen on immunohistochemical or histopathologic examination. The liposome released atranorin to the aqueous phase by the addition of albumin or albumin-like proteins.

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Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Contrary to the view that caspase-mediated apoptosis represents the standard programmed cell death, recent studies indicate that an apoptotic morphology can be produced independent of caspases, that autophagic execution pathways of cell death may be engaged without either the involvement of caspases or morphological signs of apoptosis, and that even the necrotic morphology of cell death may be consistently produced in some cases, including certain plants. We report the conditions required to generate adult murine dentate gyrus precursor cell cultures and to analyze functional properties of precursor cells and their differentiated granule cell-like progeny in vitro. Some philosophical speculations about the concept of the genital character. The records of all patients seen at the Ataxia-Telangiectasia Clinical Center from July 1, 1995 to April 1, 1997 were reviewed to determine age of onset of gait abnormality, recognition of telangiectasia, and diagnosis.

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difficile strain 1470 serotype F (TcdBF) induced a strong upregulation of RhoB. Effective switch-on fluorescence sensing of zinc(II) ion by 8-aminoquinolino-beta-cyclodextrin/adamantaneacetic acid system in water. Historically, nipple feeding in the NICU has been initiated and advanced by physician order based on nursing observation and suggestions. To study the efficacy, safety, and feasibility of implantation of a bag-in-the-lens intraocular lens (IOL) in children and babies.

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We have used NMR to monitor the effect of this osmolyte on amide hydrogen exchange rates, which allows a probe at discrete points within the protein structure. In the selected cases, use of the subcutaneous island pedicle flap is a viable method to be considered for reconstruction after resection of earlobe keloids. Mesenchymal human fibrosarcoma HT1080 cells, which have naturally high levels of endogenous and exogenous PGI/AMF, were stably transfected with PGI/AMF small interfering RNA (siRNA). Dibutyryl cGMP, like acetylcholine, shortens and reduces repolarization and overshoot of the action potential, slightly hyperpolarizes the cell and decreases the force of the contraction in the atrial working muscle. Therefore, locomotor costs are driven more by ecological relevance than by the need to optimize locomotor economy.

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Several epileptic syndromes are associated with photosensitivity with or without visually-induced seizures. These results suggest an AT1 receptor mediates uptake and transport of angiotensin II at the blood-brain barrier and may contribute to the regulation of cerebrovascular levels of the peptide. Ventilator-related Acinetobacter outbreak in an intensive care unit.

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Transfectants expressing betagal were able to invade host cells and proceed through part of the life-cycle, forming schizonts from which merozoites were released. To investigate the effectiveness of two alternative vein-graft surveillance strategies. Information about firearm-related injuries in Washington state was extracted from computerized death certificate and hospital discharge files for the period 1989 through 1995.

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These results have several implications for prevention, etiology and treatment. It is based on the Model for standard development and was successfully implemented in a nursing service. Structural studies on HLA-G: implications for ligand and receptor binding. These findings have significant implications for the dynamics of adaptation. Plasma free amino acids were determined in the plasma of severely malnourished children under two years of age.

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Five underwent retrograde fixation with two C-shaped nails inserted from medial and lateral entry portals. The spectrum of chronic liver disease in renal transplant recipients.

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LF cell cultures were then exposed to various concentrations of Ad/lacZ (25, 50, 75, 100, 150 multiplicity of infection) and BMP-2 (50, 100, 500, 1,000, and 1,500 ng/mL). The mechanism of this phenomenon includes oxidation of SH groups of the enzyme. However, the high interindividual variability and the temporal variations of the Doppler signal still limit the value of these criteria for prospective diagnosis. Subsequently, MITF and PU.1 recruited coactivators to these target genes, resulting in robust expression of target genes. The results were compared with the clinical development of the disease and localization of vestibular problems.

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To determine the efficacy of inhaled cromones in the management of prolonged non-specific cough in children. The use of this system for stereotactic craniotomy increased the safety of the surgery by affording preoperative simulation and intraoperative localization with the three-dimensional functional images. Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis: evaluation of a 6-week course. Participant criticisms and suggestions that will likely contribute to program enhancement notably included expressed desires for further observation and practice prior to facilitation of a PBL student learning group and availability of ongoing follow-up training and support for fledgling facilitators. Angiotensin II receptor antagonist telmisartan in isolated systolic hypertension (ARAMIS) study: efficacy and safety of telmisartan 20, 40 or 80 mg versus hydrochlorothiazide 12.5 mg or placebo.

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At baseline and followup, men completed questionnaires that elicited urinary symptom severity with questions nearly identical to those of the American Urological Association symptom index: Many factors contribute to inadequate nutrition, including health status, financial capacities, mobility, exercise, and physiologic needs. Preoperative EMG activity from the splenius and longus capitis muscles showed a pattern of alternate activation of the antagonist neck muscles in all the cats.

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Calculating the risks and benefits of agricultural pesticides determines whether a pesticide will be registered for use on commodities. Fibers from receptors in the right atrium and the carotid arteries project to the lateral solitary nucleus and then to the medial and the lateral nucleus intercalatus. We conclude that diffuse enhancement indicates extravasation from broken vessels that continue to bleed and that diffusely enhancing hematomas will be rapidly enlarged. None of the available drugs for chronic obstructive pulmonary disease is able to reduce the progressive decline in lung function which is the hallmark of this disease.

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However, the lack of understanding of the molecular basis of some of the clinical features of glycogen storage diseases makes it difficult logically to devise optimal treatment regimens to prevent some of the long-term complications. Further studies are needed to elucidate completely the details of apoptotic control in normal skin and determine factors resulting in apoptotic disbalance and disease.

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Morphological changes in the kidneys of pigs with an adenovirus infection In the context of the 1997 Report of the Medical Workforce Standing Advisory Committee, it is important that we develop an understanding of the factors influencing medical school retention rates. Rim enhancement with Gadolinium-DTPA was less frequent in vertebral osteomyelitis. Palladium-catalyzed carbocyclization of 1,6-enynes leading to six-membered rings or oxidized five-membered trifluoroacetates.

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Computation of relative risk based on simultaneous surveys: an alternative to cohort and case-control studies. 21 consecutive patients with heart failure and severely impaired left ventricular function were studied. Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia.

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Provider satisfaction increases the likelihood of provider retention in any practice. Use of a coaxial needle sampling technique with immediate microscopic assessment reduces the likelihood of retrieving only blood or necrotic tissue in the electron microscopy specimens. Roundoff-induced periodicity and the correlation dimension of chaotic attractors. Other important outcome criteria are treatment side effects especially the quality of life (QoL). This resulted in a reduction in the number of days patients were on a ventilator and a reduction in the ICU length of stay for patients with acute respiratory failure requiring mechanical ventilation.

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Myocardial perfusion was measured using radiolabeled microspheres at baseline, 30 and 60 min after either MgSO4 (80 mg/kg) or saline infusion. Using reverse-transcription polymerase chain reaction (RT-PCR) and Northern blot analysis we have shown that endoglin mRNA is expressed in both cultured human VSMCs and VSMCs freshly isolated from human aortas. For the single-stranded RNA the high temperature wave occured only at the high ionic strength. A detailed field study of several chert horizons and chert veins that range in age from 3.47 to 3.30 Ga revealed the importance of syndepositional hydrothermal activity for their origin. Six haplotypes were detected by direct sequencing and four by RFLP analysis.

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The ultrastructure of vascular tumors: additional observations and a review of the literature. Conditions for the primary culture of eye imaginal discs from Drosophila melanogaster.

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In this study, graduates of two surgical programs were surveyed to characterize their research experience and to determine the effects on their careers. This warrants further research on the mechanisms of action and potential efficacy of fenretinide and provides the rationale for a Phase III primary prevention trial in young women at high risk for breast cancer. Dysfunctional telomeres induce p53-dependent cellular senescence and apoptosis, but it is not known which function is more important for tumour suppression in vivo. Synergism between Ang-2 and VEGF and its application of anti-angiogenesis in tumor therapy - review Further studies are warranted to determine if this pigmentation disorder represents a spectrum of histopathologic change or, in fact, should be renamed mucocutaneous lentiginosis of Laugier and Hunziker.

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Both patients of group C showed negative immunoscintigraphy, due to the small dimensions of the tumors (less than 2.7 mm). IFR can be eradicated by inspection and culling but latent infections, which may persist undetected for at least 34 weeks, require surveillance inspections to be repeated during the non-transmission phase of the program. Fifteen patients who developed prolonged psychotic reactions following psychotomimetic drug use (probably primarily LSD) were followed up 1.9 to 5.8 years later.

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A review is presented of the various types of cardiotoxicity associated with the clinical use of doxorubicin, a highly effective antineoplastic agent of the anthracycline family. Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Similar results were obtained when the sera were tested by western blotting and dot blotting. The effect of working parameters on root substance removal using a piezoelectric ultrasonic scaler in vitro. In May and June 2002, 1218 London MSM completed a self-administered questionnaire online, accessed through Internet chat rooms and profiles on gaydar and gay.com.

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We classified the signs of AIDS following that of CDC-Atlanta 1994. Catheter-related damage to the intima, chemical damage by irritating medications and reduced host resistance attributable to the underlying illness were thought to be possible causes of the thrombophlebitis. The persistence of respiratory symptoms are nevertheless suggestive, above all in a subject belonging to a group at elevated risk of tuberculosis. Comparison of environmental monitoring protocols for the detection of Salmonella in poultry houses. Although considerable structural characterization of prion protein has been reported, neither the method of conversion of cellular prion protein, PrPC, into the pathogenic isoform nor the post-translational modification processes involved is known.

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The application of Fourier transformation to the well-defined cyclical count rate variations revealed two areas with high amplitude values but with phase opposition. Biochemical and genetic studies have identified several adhesion and signaling molecules that localize to synapses and might participate in organizing synaptic structures. The conformational properties of model BB with and without an intramolecular disulfide bond (BB-O and BB-R, respectively) were characterized by NMR and CD spectroscopy. Variations in fraction hemoglobin A0 reflect differences in in vitro oxidation rates to methemoglobin. Infusion versus bolus injection of Tc-99m tetrofosmin in the identification of viable myocardium.

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Attempted treatment of a voluminous tympano-jugular and retropharyngeal glomus tumor by embolization The histological examination revealed a double component: epithelial, papillomatous and acanthosic on the one hand and vascular and lymphatic on the other, suggesting a lymphangioma with epidermal hyperplasia. Clue word presentation enhanced the reading of beginning-same and end-same target words more than middle-same target words.

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The surgical pearls and pitfalls of anterior cervical arthroplasty are highlighted. In this article, we describe the history of genetic manipulation in Francisella and summarize the current tools and techniques for conducting genetic studies in this organism. Mediterranean spotted fever with acute renal failure stimulating a relapse in C-ANCA vasculitis.

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In this study we examined the mechanism of TNFalpha induced osteoclastogenesis and its downstream signaling. The exposure of one TCR (Valpha2Vbeta5) to antagonist peptides could not inhibit a second independent TCR (Valpha2Vbeta10) from responding to its antigen.

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They found the rehospitalization rate was higher for schizophrenic patients than for patients in other diagnostic groups, and that schizophrenic patients who did not enter aftercare were rehospitalized at a higher rate than those who did. However, subgroup analyses showed that the P1A2 polymorphism of GpIIIa appeared to be associated with stroke risk among white women, particularly those with a clinically identified probable etiology for their stroke. Cortisol is the hormone reacting to endogenous and exogenous stress.

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The second and third treatment of the hydrogenated oil with pectinic acid resulted in a high degree of heavy metal removal. To examine the acute effects of static stretching on peak torque, the joint angle at peak torque, mean power output, and electromyographic and mechanomyographic amplitudes and mean power frequency of the vastus lateralis and rectus femoris muscles during maximal eccentric isokinetic muscle actions.

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The reshaping and functions of the actin cytoskeleton are regulated by signaling pathways. A molecular model defined a hydrophobic region (Phe168) in the putative A(3)AR binding site around the phenyl moiety.

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Sperm-specific histone variants Sp H1 and Sp H2B are maintained as phosphorylated derivatives N and O/P throughout spermatogenesis and early embryogenesis and egg specific histone variants CS H1 and CS H2A are phosphorylated during early embryogenesis. Absolute diagnosis of lumbar zygapophysial joint-mediated pain is based on selective analgesic injections of these joints or their nerve supply. Despite an improvement of articular symptoms, infliximab treatment had no distinct effect on the histopathology of rheumatoid nodules, suggesting that different pathogenetic mechanisms mediate the two disease manifestations in RA. Laboratory surveillance of hepatitis C virus infection in England and Wales: 1992 to 1996.

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Dexamethasone does not impair the antibacterial efficacy of gentamicin for PA and SA. Combined treatment with growth hormone and gonadotropin-releasing hormone analogues in children with isolated growth hormone deficiency. NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy. We intend to describe the modulation of generalized ectromelia virus (EV) infection with exogenous administration of mrIFN-gamma and mrTNF-alpha separately and in combination using susceptible BALB/c mice.

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The relationship between cytochrome c-420 content and photophosphorylation. Modulation of the antibody response to sheep erythrocytes in murine spleen cell cultures by a T cell mitogen extracted from Bordetella pertussis. After further examination, two of the five workers were diagnosed to suffer from occupational liver damage. In this report, we have characterized the distribution, molecular variability, and organization of ORFs 1, 2, and 4 and the IR elements among isolates of the Borrelia burgdorferi sensu lato complex.