Lodales is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins. " It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

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There was one discrepancy between the simulated and in vitro results. In a Phase III breast cancer prevention trial, fenretinide showed a strong trend of reduction of incidence of second breast malignancies in premenopausal women, which was confirmed by 15 years of follow-up. At the 15th month of follow-up there was a change in the pituitary CT scan, presumably due to pituitary revascularization. In these programs home care services deliver complex treatment to patients with acute conditions under the supervision of their physician. Obstetric dimensions of the true pelvis in a medieval population from Sudanese Nubia.

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Diagnosis may be made safely in the presence of a characteristic collateral history. Implications of comorbidity for research on the nature of psychopathology and the ultimate integration of dimensional and categorical features in our nosology are considered. Destabilizing effect of temperature modulation on time-dependent convection in 3He-4He mixtures.

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The crosslinking process of the matrix film was shown to be an interfacial phenomenon and the nature of crosslinking depends on the crosslinker type and concentration. Cyclooxygenase 2 expression in cervical intraepithelial neoplasia and vulvar cancer.

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In neutralization experiments, anti-LFA-3, -CD44v6, -CD15, -VLA -4 and anti-CD13 mAb reduced the lymphocyte adhesion to untreated and docetaxel treated cells at different degrees, while CEA mAb increased the adhesion. The ability to harness GPCRs for BioMEMS applications by using cells that are easy to grow on MEMS devices and to modify genetically opens the way for a new generation of devices based on these naturally selective and highly sensitive chemoreceptors. Nuclear gene-induced variegation mutants provide a powerful system to dissect interactions between the genetic systems of the nucleus-cytoplasm, the chloroplast, and the mitochondrion. Cap analogs m7GMP and m7GDP inhibit binding of eukaryotic initiation factors to reovirus capped mRNA but also inhibit complex formation involving uncapped mRNA or 18 S rRNA.

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Tissue and plasma samples were analyzed for GSH at 2 and 4 hours after drug administration. The results are well maintained at 5 years follow-up with low reoperation rates. The authors undertook this study to assess the impact of this legislation on the frequency of helmet use in children involved in bicycle crashes presenting to the regional pediatric trauma center, and to assess the impact of helmet use on the number and severity of head injuries. Presence of purpura, particularly when generalized, is an important predictor of a poor outcome following meningococcal infection.

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Women at two outpatient clinics in Brazil filled out a questionnaire and were examined for the presence of vulvovaginal candidiasis or bacterial vaginosis. It is not needed, however, for the repression of the same promoter, indicating that different domains of p53 are involved in activation and repression.

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Protein phosphorylation: technologies for the identification of phosphoamino acids. Following tumor reduction by Nd-YAG laser, it was clear that the primary lesion originated from the left upper bronchus.

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Insoluble elastin has been isolated from bovine ligamentum nuchae by treatment with quanidine and dithiothreitol followed by digestion with collagenase, purified by affinity chromatography. Immunostaining showed the distribution of prosomes in the cytoplasm and nuclei of cells from European normal women (EN) and Parsi (P) and non-Parsi (NP) benign (B) and malignant (M) tissues. The correlation of the lipoprotein (a) level of the blood serum with the degree of coronary atherosclerosis

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Case report: Haemangioma of the small intestine complicated by protein-losing gastroenteropathy. Both lines had a normal karyotype but showed deletion of the Ink4a/ARF locus.

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Very little research has been performed to establish the efficacy of spine-board transfer techniques. p53 and the p73 proteins activate transcription from p53-responsive promoters. The changes in lung function were related to younger age at treatment and to more dose-intensive treatment protocols that specified more use of cranial irradiation and higher cumulative doses of anthracyclines, cytosine arabinoside and intravenous cyclophosphamide than previous protocols. The GABAA receptor antagonist bicuculline and 3-amino-1-propanesulfonic acid-induced tachyphylaxis, but not the GABAA-associated chloride channel blocker picrotoxinin, caused a modest reduction in the secretory responses to capsaicin.

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Our results indicate that although both constitutively activated cEpoR and BCR-ABL oncogenes induce growth-factor independence in Ba/F3 cells, only BCR-ABL is able to protect cells from etoposide and serum-deprivation-induced apoptosis and induce a strong constitutive activation of STAT factors, suggesting a role for these molecules in the anti-apoptotic activity of BCR-ABL. These results seem to indicate that there are differences between the isolates obtained from hosts in different geographical regions. Investigators surveyed all of the Massachusetts home ventilator clinics, pediatric pulmonary services, hospital-based pediatric services for special health care needs, insurers, home care vendors, nursing agencies, the Massachusetts Department of Public Health, selected individual providers, and rehabilitation and long-term care facilities providing services to children with chronic respiratory support needs. The affinity enrichment process commonly known as biopanning relies on subjecting a library of peptides on filamentous phage to a selection for binding to the target immobilized on solid support or in solution. Ultraviolet-induced DNA damage stimulates topoisomerase I-DNA complex formation in vivo: possible relationship with DNA repair.

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Universal lingual arch wire: combination appliance for orthopedics and orthodontics. The mouse intensity-response functions to 15-Hz flickering stimuli possessed the same features as that of humans - a local amplitude minimum and a rapid phase change in the intensity region where the primary and secondary pathways are mutually inhibitory. an improvement in leaching out of more deeply entrenched materials.

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We searched for arguments favoring an articular origin which would have an impact on management and risk of recurrence. Chromatographic conditions using a 0.01 M potassium phosphate or 0.1 M NaCl as solvent in the isocratic mode are described for the separation of estrone glucosiduronate, 17beta-estradiol-3-glucosiduronate, 17beta-estradiol-17-glucosiduronate, estriol-3-glucosiduronate, estriol-16alpha-glucosiduronate, estriol-17-glucosiduronate, estrone sulfate and 17beta-estradiol-3-sulfate.

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We have now used these packaging cells to construct a new adenoviral vector (Ad5.betagal.DeltaF) with E1, E3, and L5 (fiber) deleted and analyzed the fiber null phenotype. Pharmacists must position themselves to differentiate among the numerous blood glucose meters available on the market and make appropriate recommendations based on patient-specific needs. Several lines of evidence indicate that these domains are oriented towards the cytosol.

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We present a patient with late-onset progressive polyneuropathy and a Congo-red positive staining of sural nerve biopsy, where routine immunohistochemical analysis failed to determine the type of amyloid deposited. Heterozygosis and genetic recombination in herpes simplex type 1 virus. To determine if scopolamine-induced cognitive impairment in healthy elderly people predicts cognitive decline 6 years later.

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Immunohistochemical demonstration of MET overexpression in human intrahepatic cholangiocarcinoma and in hepatolithiasis. A clinical example is offered to demonstrate the resultant problems. They were compared with 25 instances of conventional open surgery performed between May 1990 and April 1996 at the same institution.

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Herniation of the temporomandibular joint into the external auditory canal: a complication of otologic surgery. We investigated whether inhibition of TGF-beta2, which is overexpressed in LCC2 tamoxifen-resistant human breast cancer cells, could modify antiestrogen resistance. The partial specific volume (V) and adiabatic compressibility (beta) of myoglobin have been shown to be reduced by small cosolvents such as glycerol (A. In this review, we describe the current knowledge of the cell biology of a key prohormone: proThyrotropin Releasing Hormone (proTRH), which is the precursor of the TRH peptide. The investigation was based on mathematical models and experiments necessary to confirm the theoretical prediction.

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Multiple myeloma-associated amyloidosis and giant cell arteritis. Cyclophosphamide at a single dose of 5 mg/l was used as positive control. Feed intake, production, reproduction, tissue residues and viability of offspring were monitored during that time and a subsequent 8 weeks.

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Although in need of further confirmation, consumption of coffee appears to be positively associated with an increased risk of thromboembolic stroke in hypertensive men in older middle-age. Despite numerous sequence analysis reports of CID variants in patients, in the past decade, CID variants have not been characterized functionally, and thus their biological significance to HBV infection remains unclear. Distinct isoforms have been shown to be exclusively activated either by tyrosine kinase-coupled or G protein-coupled receptors.

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The ability of VSMC to produce PGI(2) was downregulated by mPGES-1 expression and was restored when mPGES-1 expression was silenced. Facilitation and depression of synaptic transmission in amphibian sympathetic ganglia. RA treatment also significantly increased UCP1 mRNA levels but to a lesser extent than CGP 12177. They were also impaired, compared to controls, on both tasks with disrupted rehearsal.

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In this study several analytical techniques were applied to obtain information about the stability of expression, the yield, and the integrity of a monoclonal antibody (Mab) produced by hybridoma cell line RIV6 in a homogeneous continuous perfusion culture system. Alternative explanations, ascribing the mechanism of neutralization to steric hindrance of critical sites or to multiple hit of those sites by antibody, were denied by analyses of the present data. The prevalence of GORD in primary care will be lower and this reduces the positive predictive value of symptoms. We found that the phosphocreatine to ATP ratio in brain was reduced, while the inorganic phosphate to phosphocreatine ratio and the calculated ADP concentration were increased. If this is true, free radical quenchers and inhibitors of leukocyte oxidative burst may be useful in the prevention of progression of atherosclerosis and coronary vasospasm.

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Pityriasis rubra pilaris complicating a dermatitis developed on a leg ulcer Acute coronary vascular and myocardial perfusion effects of conjugated equine estrogen in the anesthetized dog. Sinus CT scanning is presently considered the most sensitive and specific diagnostic method, but is expensive.

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Collision-induced coherence transfer studied by tunable energy compensation. Maternal care of rabbits in the lab and on the farm: endocrine regulation of behavior and productivity. This result provides evidence of a change in the postural control of the trunk in people with LBP. One hundred and thirty-eight adults were common to both studies.

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Surgical factors included knee/hip arthroplasty, unilateral/bilateral arthroplasty, and indication for surgery. Primary vaccinations were followed by two booster immunizations at 2 and 6 months. Biological and serological characterization of radiation leukemia virus. The results of subtotal colectomy for slow-transit constipation are unpredictable. Characterization by scanning transmission electron microscopy of silica particles from alveolar macrophages of coal miners.

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Cross-reactive type IV hypersensitivity reactions to benzodiazepines revealed by patch testing. The somatogenic binding sites were present in both males and females, and the number of sites was similar in females and in males and was not affected by hypophysectomy. Characterization of the in vitro antiepileptic activity of new and old anticonvulsant drugs. Encapsulated, type b, or typable H influenzae is the strain implicated in childhood infections.

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Mounting evidence indicates that certain nucleotide sequences impose non-canonical secondary structures on DNA. The pH rose, and alkalinity generation and bacterial growth were observed. The host replication protein A (RP-A) was also colocalized to these foci. Concentrations of cadmium, copper and zinc have been analyzed in muscle, liver and kidney tissues of fin whales (Balaenoptera physalus) from two locations in the North Atlantic, Iceland and Spain. In this study, children with greater caries experience showed more gingival inflammation.

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Xylose was found to be the most abundant noncellulosic neutral sugar associated with fruit walls, and the observed high Xyl/Glc ratio suggested that xylans, which are usually a minor hemicellulosic fruit wall component, are abundant in blueberry. The following regions, which were visualized by using Timm staining, were included in the analysis: 1) outer portions of the dentate gyrus molecular layer (OML) innervated by the lateral entorhinal cortex, 2) middle portions of the molecular layer (MML) that receive input from the medial entorhinal cortex, 3) the commissural/associational zone (IML) immediately adjacent to the granule cell layer, and 4) the hilus and mossy fiber projection to the CA3 pyramidal cell field (MF).

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In rod mass receptor photoresponses recorded across the isolated frog retina, a paradoxical cornea-positive wave may precede the response of normal polarity. There were no significant differences in the rates of ventilator-associated pneumonia, the duration of the stay in the ICU, or mortality.

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The tumors of all rats disappeared within 2 weeks after chemotherapy, but the T/N ratio did not change. The CRDs were determined based on the metabolic flux ratios obtained from (13)C-labeling experiments, and were incorporated into the mass balance equations for the artificial metabolites. Although a low concentration of penicillin in the medium was used, it caused a significant allergic reaction.

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Types of psychosocial job demands and adverse events due to dental mismanagement: a cross sectional study. Such lesions include chondroblastoma, osteoid osteoma, eosinophilic granuloma, and stress fractures. Furthermore, complementation experiments showed that Escherichia coli RecD, helicase domain or N-terminal domain of D. Reaction slug dilution and UV slug detection took place at the outlet. Rather than cutting or burning tissue, plasma allows us to ablate tissue using very low powers and even allows for portable systems.

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However, evidence supporting the efficacy of thrombolysis in reducing mortality after acute myocardial infarction is less clear cut in patients aged 75 years or above than in younger patients. A 14-year-old girl with partial unilateral lentiginosis affecting the left side of the neck, left shoulder and left upper arm is described. Regulation of the GTPase activity of the ras-related rap2 protein. We found that apoptosis of H9C2 cells, induced by serum withdrawal and doxorubicin, was associated with the induction of Bax and the activation of caspase 3.