Mecox is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Mecox is also used to relieve the pain, tenderness, swelling, and stiffness caused by juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older. Mecox is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

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Mutations of one of the residues in this region, Leu-25 in IL-8, to tyrosine (which is conserved at this position in CC chemokines) enables the mutant IL-8 to bind CC chemokine receptor-1 (CC-CKR-1) and introduces monocyte chemoattractant activity. A 43-year-old man manifested rapidly progressive left-sided ptosis, bilateral abducens palsy, areflexia, and severe ataxia. Genomic organization and expression of the CXCR4 gene in mouse and man: absence of a splice variant corresponding to mouse CXCR4-B in human tissues. Chromosomal aberrations and in vitro radiosensitivity: intra-individual versus inter-individual variability.

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Whereas specimens examined after 2 weeks showed antibody formation in only one animal (500 HESWs), being located in the tubular tissues, all treated kidneys demonstrated various degrees of antibody formation in both tubular and glomerular tissues after 3 months. The study of neurological impacts of toxicants has emphasized neuropsychological tests as important outcome variables. In contrast, FGF-2 was only effective in reducing the deficits in skilled forelimb movements when the FGF was given postnatal (i.e., postsurgery). The thread-forming rod is then removed leaving a threaded channel in the cement.

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These data suggest that the lack of cooperation by some patients affected by Mental Retardation is related to fear, anxiety, and incapacity to communicate rather than to the degree of Mental Retardation. Validity of bioelectrical impedance equations for estimating fat-free weight in lean males.

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The interaction could be due to the influence of the drug on GABA levels at cardiovascular regulatory sites. Heterozygous mutations in the NIPBL gene were found in about half of CdLS cases. Diagnostic laparoscopy and laparoscopic appendectomy in the diagnosis and therapy concept of abdominal pain of unknown origin

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Alterations in acetylcholine synthesis and cyclic nucleotides in mild cerebral hypoxia. Stable transfection experiments, however, showed that neither cAMP or PMA alone nor together affected FN promoter activity. Nitric oxide is critical for inducing phosphatidic acid accumulation in xylanase-elicited tomato cells. With the cloning of ermE and am and their expression in different strains of Amycolatopsis, we have overcome the problem of the choice of suitable selectable markers for A.

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Outcome after radiosurgery for brain arteriovenous malformations Immunohistochemistry revealed a high level of expression of cyclin E in a subset of gynecologic carcinomas, namely clear cell carcinomas, but not in clear cell carcinomas of renal origin. Characterization of the zinc-containing metalloprotease encoded by zpx and development of a species-specific detection method for Enterobacter sakazakii.

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This is the first study to evaluate the effects of a topical antibiotic on Pseudomonas biofilms in an animal model of sinusitis. The structure of a haem-myoglobin adduct has been defined by the use of stable isotope studies.

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Early identification of left ventricular remodelling after myocardial infarction, assessed by transthoracic 3D echocardiography. Two main groups were selected for this study: 133 patients suffering from a myeloproliferative disorder and 382 patients affected by a lymphoproliferative disorder. Interestingly, ursolic acid also reduced the expression of the NADPH oxidase subunit Nox4 and suppressed the production of reactive oxygen species in human endothelial cells.

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Near-threshold photodetachment of H- in parallel and crossed electric and magnetic fields. In lymphocytes from the control group, deoxy-D-glucose uptake increased gradually with the duration of the experiment. Noninvasive procedures for diagnosis of renovascular hypertension in renal transplant recipients--a prospective analysis. However, alphaB-crystallin did not bind MTs reconstituted from purified tubulin. Although meat is a widely consumed protein source, little is known of its digestion rate and how it can be affected by the chewing capacity of elderly subjects.

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Basic fibroblast growth factor (bFGF) delays photoreceptor degeneration when injected intraocularly in Royal College of Surgeons (RCS) rats with inherited retinal dystrophy. Interestingly we have found evidence for only two tandemly linked PGK genes which correspond to the PGK gene B and C homologue in Trypanosoma and Crithidia. The purpose of the study was to evaluate the results of retreatment for low myopia after primary photorefractive keratectomy (PRK). Poorly differentiated synovial sarcoma: an analysis of clinical, pathologic, and molecular genetic features.

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Double-blind trials are necessary for future research into the control of pain and weight loss. Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards. Fourteen children required admission and manipulation under anaesthesia. Here we extend the idea of SOGL to the detection of significant prognostic marker genes from microarrays of multiple data sets. Clinical analysis of choledochoduodenal fistula with cholelithiasis in Taiwan: assessment by endoscopic retrograde cholangiopancreatography.

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Malignancy and vertebral tuberculosis were the major differential diagnoses. An unusual presentation of transitional cell carcinoma of the distal urethra. Assessment of anxiolytics (6)--A novel method in mice using psychological stress Patients infected with a HCV genotype 1 prototype sequence should be counseled before receiving combination IFN-alpha and ribavirin therapy as they have a poor response to treatment. Staining of argyrophilic nucleolar organizer regions (AgNORs) is a histological technique that has been assayed on a vast array of cutaneous tumors in order to help distinguish benign from malignant lesions.

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Cellular metabolic control by chemical modification of cell membrane. The effect of the human trophoblast hormones chorionic gonadotropin (hCG) and placental lactogen (hPL) on the expression of cytokines in peripheral blood mononuclear cell cultures was followed under a variety of culture conditions, (a) phytohemagglutinin stimulated cells (PHA-MSC), (b) allogenic mixed cells (AMC) and (c) spontaneously proliferating cells (SPC).

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Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions. Unlike the rate of change in BP and heart rate, deltaSrvO2 values were significantly different at different rates of blood removal. High affinity binding of beta-adrenergic receptor kinase to microsomal membranes. This beta-glucosidase activity, localized predominantly in the microsomal fraction, was optimally active in the presence of divalent metal ions close to pH 5.0 and was inhibited by EDTA. In animals with chronic persistent infection with high levels of circulating antibody, infectious virus was consistently isolated from the salivary gland and pancreas.

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Transfusion in the patient with sickle cell disease: a critical review of the literature and transfusion guidelines. Fifteen patients, 11 men and 4 women with a mean age of 64.1 years (range, 35.7 to 78.0 years), underwent operation for triple-vessel disease using minimal access techniques.

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A multicentric lesion should always be thought of when the symptoms cannot be related to a single focus and when the special investigations do not confirm a single lesion. Neurological symptoms were described in only one of these families but cerebral imaging was not performed. In genotype 1 infected patients, low pretreatment serum interleukin-8 is associated with virologic response to interferon-alpha-based therapy. We report here additional occurrences of this domain in Ran-binding proteins of the RanBP1 family and various others proteins, or putative proteins of eukaryotic organisms, suggesting that the EVH1/WH1 domain may be more widely used than originally thought.

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Little mental disorder research in general medical journals in low - and middle-income countries. MRCP with FIR was a useful adjunctive tool for non-invasive evaluation of patients with obstructive jaundice. Furthermore, the LPS-activated DC precursors reduced bystander DC maturation and anti-CD3/CD28-triggered T cell activation. Self-reported height and weight were used to calculate body mass index. The specimens were immunostained for COX-2 and DNA-Topo IIalpha as an index of cell proliferative activity.

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These studies suggest that cyclic AMP is the key to regulation of platelet aggregation and that PGE, formed by platelets, through its effects on cyclic AMP may play a role in regulating platelet aggregation. To compare the average and marginal life-time cost-effectiveness of increasing dosages of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, such as lovastatin, for the primary prevention of coronary heart disease (CHD). Minor alterations in the tertiary structure of thermally denatured myoglobin (denaturation temperature ranging between 30-70 degrees C) do not affect its affinity and the modality of binding with the drugs, but alterations in the secondary structure of the protein denatured at temperatures between 70-80 degrees C influence its binding. These findings suggest a pivotal role for P-GAL3 in promoting TRAIL sensitivity through activation of a nonclassic apoptotic pathway and identify P-GAL3 as a novel regulator of PTEN. Effect of carbohydrate source on lipid metabolism in lactating mice and on pup development.

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Multiple tissue Northern blot analysis revealed that the MT1-MMP message was expressed highly in the enamel organ and pulp organ when compared to the expression levels observed in other non-mineralizing tissues. When twin pairs solely were analysed, significantly elevated IgA antibody levels suggestive of persistent infection were found among the currently or formerly smoking men compared to their non-smoking co-twins.

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Establishment and characterization of 2 cell lines of squamous epithelial carcinoma of the mouth floor and tongue Molecular cloning of a cDNA for a pepsin inhibitor in the round worm, Ascaris suum, was achieved.

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The punctum plug as an option for treating retrograde air flow from the lacrimal sac Viral recombination was assessed using a sliding window technique and phylogenetic tree analysis. Fast cognitive decline at the time of dementia diagnosis: a major prognostic factor for survival in the community. The effect of substituting milk for apple juice on urine composition and risk of calcium oxalate precipitability was studied.

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Cat-scratch disease warrants extensive investigation, from an epidemiological, a diagnostic, but especially a therapeutic point of view. The ability to keep this information confidential is questionable, particularly in view of the expansion of electronic medical databases. Skin lesions resolved after 2 to 4 weeks in treated as well as in nontreated children. Reperfusion and postconditioning in acute ST segment elevation myocardial infarction. The 43kD protein treatment in animals either prior or post to fluoride administration normalized the levels of parameters measured and restored the SOD activity in mice erythrocytes.

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Unequal amplitude saccades produced by aniseikonic patterns: effects of viewing distance. A comparison of fetal and infant death rates in the progeny of radiologists and pathologists.

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The number of cells used for immunotherapy of repeated spontaneous abortion influences pregnancy outcome. In future, we need COPD specific anti-inflammatory agents, including histone deacetylase (HDAC) activator.

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These findings suggest a rationale for such an approach in patients with inflammatory carcinoma and may be applicable to patients with stage III breast cancer in whom the primary tumors are locally advanced and technically difficult to resect. An attempt was made to obtain information on amine uptake into cortical cells using the Falck-Hillarp technique to analyse the in-vivo and in-vitro uptake of noradrenaline (NA) into the adrenal cortex in adult rats.

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The administration of antiplatelet drugs and vasodilators that prevent the effects of thromboxane A2 and serotonin may be beneficial for gastroepiploic graft function. violaceum ATCC 12472 is now available, and it has considerable biotechnological potential for various applications, such as environmental detoxification, as well as medical and agricultural use. The Office for Human Research Protections (OHRP) within the US Department of Health and Human Services aims to protect human research subjects without hampering scientific progress. To assess whether the absence of alpha-tocopherol from the diet of young laboratory animals may be considered a reliable model of precocious brain aging, intracellular ionic content of brain cortex pyramidal cells, ultrastructural features of synaptic contact zones, synaptic mitochondria and perykarial mitochondria positive to the succinic dehydrogenase (SDH) histochemical reaction with copper ferrocyanide have been investigated by X-ray microanalysis and computer-assisted morphometry in young, adult, old and 11-month-old vitamin E deficient rats. Although nonspecific DNA synthesis is generated under these conditions, one can develop the confidence of synthesizing DNA inside the nucleus and appreciate the importance of protease digestion time to successful RT in situ PCR.

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This system was used to study the dsRNA binding and dimerization requirements for over-expressed PKR mutants and subdomains to affect DHFR translation. Overweight and obese individuals mentioned more frequently that their general practitioner discussed physical activity or checked their weight, which was not explained by chronic diseases or the number of ambulatory care visits. Salivary ghrelin levels at 02:00 h were markedly elevated in patients with atopic dermatitis compared to those in healthy children. They have an abundance of mitochondria, which is manifested as granular eosinophilic cytoplasm by light microscopy.

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Terahertz time-domain spectroscopy of imidazolium ionic liquids. In situ hybridization histochemistry was used to investigate acute estrogen effects on serotonin 5HT1A receptor mRNA levels in limbic-related brain areas in the female ovariectomized rat. To determine if patient-specific prescriber feedback for general medical practitioners (GPs), supported by educational material mailed to their patients, would increase home medicines review (HMR) rates.

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Beside the documentation it is the object of the graphical presentation of dose distribution in radiotherapy to clarify for better judgement. Each insertion site then can be amplified and sequenced systematically. The cofactor proteins were relatively soluble both at high and at low pH. The core translocon, the SecYEG complex, forms oligomers, but the protein-conducting channel is at the center of the monomer. Biotransformation by plant cells immobilized in cross-linked polyacrylamide-hydrazide.

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Computerized axial-tomography in the preoperative evaluation of an angiofibroma. By reviewing several characteristic examples from Istria and the region of Kvarner, the importance of this veneration is indicated, for general and religious tradition as well as for the history of medicine, especially the history of ethno-ophthalmology. Since DNase II activities in these tissues were closely correlated to each other, systemic regulation of the enzyme was suggested. Percutaneous balloon pericardiotomy can be undertaken as a minimally invasive treatment of symptomatic pericardial effusion.

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We inoculated cell culture-produced genotype 2a (JFH-1) HCV intravenously. Clinicians treating alcoholism and tobacco dependence may need to screen for problem gambling.

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The effect of pH, Mg-ATP, and free calcium on activity of the inner dynein arm was investigated using demembranated human spermatozoa lacking the outer dynein arms (LODA). Phosphorus concentration remained constant at 0.4 g/100 g diet resulting in Ca:P molar ratios of 0.48, 0.96 and 1.92, respectively. The role of nitric oxide in physiologic functions and pathologic conditions

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The antidepressants desipramine and fluoxetine were compared in vivo to the glucocorticoid prednisolone, an anti-inflammatory drug of reference. They had increased intelligibility by adding more word-specific articulations but still had difficulties with novel and complex material. Moreover, overexpression of a dominant negative FGF receptor, which blocks endogenous FGF signaling, leads to decreased p90(rsk) kinase activity.

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An analysis of prognostic factors in response to conservative treatment of postmastectomy lymphedema. These results point to GSH depletion as a mediator of TNF-alpha action in HSC. Luminal cells of fetal canalized glands continue to express CK19, EGFR, and BCL2, without p27 expression. Continuous infusion of high-dose omeprazole is more effective than standard-dose omeprazole in patients with high-risk peptic ulcer bleeding: a retrospective study. The slightness of non-hematological toxicity of STI571 in the treatment of chronic myeloid leukemia suggests this drug is relatively safe.

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S-ethylisothiourea, a nonamino acid inhibitor of nitric oxide synthase, reverses septic vasodilation in sheep. Effects of failed oocyte activation and sperm protamine deficiency on fertilization post-ICSI. In addition, PDLIM2 targeted p65 to discrete intranuclear compartments where polyubiquitinated p65 was degraded by the proteasome. This specific type of anemia has been termed anemia of chronic inflammation.