Neozentius is the S-enantiomer of the racemic compound citalopram, a selective serotonin reuptake inhibitor (SSRI) widely used for the treatment of depression. This review describes the current body of pharmacologic and clinical evidence supporting the use of Neozentius for the treatment of depression and anxiety. Preclinical studies have confirmed that it is primarily this molecule that provides the inhibition of serotonin reuptake responsible for the antidepressant effect of citalopram, with minimal-to-nonexistent affinity for other receptor sites. Clinical trials of Neozentius in depressed patients indicate that Neozentius, 10 mg/day, is as effective as 40 mg/day of its parent compound, citalopram, with an excellent safety and tolerability profile. Because of its increased selectivity, Neozentius represents a refinement in SSRI therapy for symptoms of depression and anxiety. This article also explores the implications of a more selective SSRI on the management of depressed patients in the primary care clinical practice.
Other names for this medication:
Escitalopram,
Lexapro,
Aramix,
Celtium,
Cipralex,
Citoles,
Ectiban,
Entact,
Esertia,
Esipram,
Esita,
Eslorex,
Esram,
Gaudium,
Lexamil,
Lextor,
Losiram,
Losita,
Neozentius,
Nexcital,
Seroplex,
Sipralexa,
Tiopram,
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Omiz,
Klax,
Diseptyl,
Antiox,
Norzen,
Secam,
Supraviran,
Alfusin,
Brevibloc,
Miravirsen,
Ciazil,
Xepar,
Lucen,
Dilox,
Florazole,
Impedil,
Vikrol,
Cardioplus,
Osyrol,
Clindacne,
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