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Neutop (Topiramate)
+ BONUS
 
Topiramate

Neutop is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Neutop antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Neutop is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain). Neutop is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Neutop is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur. Neutop is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

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Experimental studies of wall interactions of adsorbed spin-polarized 131Xe nuclei. Management of post-tracheotomy scars and persistent tracheocutaneous fistulas with dermal interpositional fat graft.

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We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Interestingly, the reaction resulted completely unselective for 3-keto-5beta-steroids by using m-chloroperoxybenzoic acid.

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Cancer mortality shows a descending trend among andalusian women, with a similar rate to the Spanish average. All subjects reported minor short-lived adverse effects following intravenous serotonin stimulation, while only half of the subjects reported minor short-lived adverse effects following intraluminal serotonin stimulations.

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The incubated fragments were extracted at increasing ionic strength. Pergolide has proven significantly superior to L-dopa plus peripheral decarboxylase inhibitor in short-term therapy of RLS/NMS.

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Following a process improvement initiative based on failure mode effectiveness analysis, left-side and right-side indicator markers, patient demographics, and date labels were identified as the most common sources of error. Corneal topography, visual acuity, and an environmental risk factor analysis were included in a screening program designed to identify early indications of potential KC in teenagers. In order to realize this goal, we founded the first European based working group on NOS. Laparoscopic splenectomy in a pregnant patient with immune thrombocytopenic purpura. HFCs were assessed using genotypes from 10 allozyme and 6 microsatellite markers in 22-month-old experimental individuals.

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There are no studies about harms of screening and interventions. 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases.

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Percutaneous fluoroscopic removal of a knotted Swan-Ganz catheter in a patient with a persistent left-sided superior vena cava. Definition of the antigenic pattern of Entamoeba histolytica, and immunoelectrophoretic analysis of the variation of patient response to amebic disease. Phase I/II study of combination therapy of oral fluorinated pyrimidine compound S-1 with low-dose cisplatin in patients with unresectable and/or recurrent advanced gastric cancer: a novel study design to evaluate safety and efficacy. It was shown, that amount of cholesterol in rat liver decreased during the first months following irradiation, and after 6 months was normal.

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A series of use errors occurred when switching an ambulatory care clinic patient from an older model to a newer model of an ambulatory continuous subcutaneous insulin infusion pump. The PNH platelet ultrastructure of resting and activated with different agonists (ADP, collagen and thrombin) showed morphological changes which suggested the presence of circulating platelets. Subsequently, germ cells were greatly depleted in the testes of 91- and 128-day-old rats with ligated epididymides. Three-dimensional core-shell superstructures: mechanically strong aerogels.

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Lymphoid cells with defects in SHIP1 and/or ptase and tensin homolog deleted on chromosome 10 (PTEN) (such as Jurkat, CEM, Molt) and, concomitantly, elevated PI-3,4,5-P(3) levels were more sensitive to the toxin than HUT78 cells which contain functional levels of both enzymes and low levels of PI-3,4,5-P(3). If seizures persisted after the loading dose, general anaesthesia (barbiturates/propofol/midazolam) was administered. There was no significant difference between the turbidity values obtained in the presence or absence of titanium suggesting that titanium does not influence the growth of plaque micro-organisms significantly.

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Histologically, the lesions centred on the nerves innervating the labial apparatus, primarily the cerebral and buccal ganglia, cerebral commissure and peripheral nerve branches arising from these. In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation. In this article the authors present relationship between meconium exposure and inflammatory cytokine release in newborn lungs.

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Gas6 is widely expressed in the rat central nervous system (CNS) beginning at late embryonic stages and its levels remain high in the adult. The effects of divided attention on encoding processes in memory: mapping the locus of interference. The sequence of changes at the site of a positive tuberculin test response were studied in 19 healthy young adults who had been immunised with BCG in childhood.

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Similar to the effect of CRF, application of the alpha 2-adrenergic antagonist yohimbine to the LC also dose-dependently enhanced memory, suggesting that CRF improved memory through activation of NE neurons in the LC. This study found no evidence to support the notion that mosaicism for FGFR or TWIST mutations, normally associated with syndromal forms of craniosynostosis, occur in single suture craniosynostosis.

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All GCTs were characterized by their PAS positive cytoplasmic granules in light microscopy, which in electron microscopy appeared as lysosome-like granules. Case reports of this clinical entity have been published, stating that the amyloid deposition leads to the symptoms of vasculitis. Simplifying the extracellular matrix for 3-D cell culture and tissue engineering: a pragmatic approach. Oxygen saturation during SPT was significantly lower during crying and other waking, and non-nutritive sucking during SPT was associated with a significant increase in oxygen saturation. The maximum mutagenic response observed in the soil extracts was 222 revertants at a dose of 10 mg of residue.

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She was referred to our department 13 months later with progressive abdominal pain and vomiting. It is anticipated that through the use of such guidelines as a supplement to the existing hematopoietic progenitor cell (HPC) regulations for tissue banks, practitioners may provide to potential patients the safest and most efficacious cord blood products currently available, and information gained through the use of these products will be of optimal value toward the goal of continuous improvement in the delivery of this new technology. This work describes a divergent strategy for the synthesis of a series of alpha-aryl-substituted fosmidomycin analogues, featuring a palladium-catalyzed Stille coupling as the key step. Sulfhydryl groups in rat brain tissue during paradoxical sleep deprivation

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FRACTURES IN CHRONIC PROGRESSIVE ARTHRITIS TREATED BY GLYCOCORTICOIDS IN CHILDREN The advantages of this method to assess cardiac wall motion in a patient with an arrhythmia were also demonstrated.

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The proposed mechanism does not support the concept of a simple invagination of the bodies into the nucleus or that they are produced in the nucleus itself. It is currently a subject of intense pharmaceutical activity, focused on developing more efficacious therapies.

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Anisotropic conduction in the triangle of Koch of mammalian hearts: electrophysiologic and anatomic correlations. Prognostic value of early response to chemotherapy assessed by the day 15 bone marrow aspiration in adult acute lymphoblastic leukemia: a prospective analysis of 437 cases and its application for designing induction chemotherapy trials.

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Three patients with GHD had fundoscopic examinations suggestive of papilledema and possibly pseudotumor cerebri. Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages. Evolution of the corticosteroid receptor signalling pathway in fish. Some of the immunolabeled cell types described here are proposed as the origins of the similarly labelled puncta and fibres on the basis of known intrinsic connections. Fifty-five coronary artery bypass patients were randomly assigned to four intervention regimens and underwent a two-hour period of 30 degrees lateral position.

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Phase and group velocities of the wave modes are derived in postprocessing steps. Mild cold stimuli favour the accumulation of proteins and of oxidative enzymes, in particular. Chymotrypsin inhibitors showed strong inhibitory effects against the further degradation of activated toxin, indicating that chymotrypsin played a major role in the process. The pulvinar nucleus, the lateral nuclear group and the anterior nuclear group take part in the language, fundamentally. The complexes are formed due to electrostatic interactions between the anionic groups of the polyelectrolyte block of the copolymers and the cationic groups of the surfactant or the homopolyelectrolyte.

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Inhibition of 3-H-noradrenalin uptake in synaptosomes by substance P Studies in vitro and in vivo with picropodophyllin show promising effects, that is apoptosis induction and growth arrest, and have made it possible to evaluate the biological and therapeutic effects of inhibition of the IGF-IR signaling in MM.

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Efficacy and safety of fluvastatin therapy for hypercholesterolemia after heart transplantation: results of a randomised double blind placebo controlled study. High prevalence of lipoatrophy among patients on stavudine-containing first-line antiretroviral therapy regimens in Rwanda. Fibrous forms are noninvasive and cellular forms have a potential for local invasion, whether shortly after birth or later with invasion of muscles, bone and meninges without intracerebral extension. By placing the model ventricle in a realistically shaped (human) volume conductor model, realistic body surface potentials (QRST waveforms) are simulated.

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Students assumed the role of a patient with a possible ankle fracture (experiment 1) or a possible deep vein thrombosis (experiment 2). However, we detected di-2-ethylhexyl phthalate, PCBs, and other impurities as interfering contaminants in several batches of silicic acid. Since in the latter group the plasma viscosity remained on elevated level, we suggest a creation of a specific feedback mechanism leading to a decrease of the blood viscosity and thus better perfusion of brain. Extensive studies reveal that these residues are localized into specific domains of visual pigments, suggesting a highly manipulated molecular architecture in visual pigments.

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At age 23, underweight was more prevalent and overweight and obesity less prevalent in the taller groups due to a linear correlation between BMI and height. We investigated the cooperativity of these two pathways in countering cyclin E-induced genomic instability in primary human cells. Conditional gene targeting using the Cre/loxP technology generally includes integration of a selection marker cassette flanked by loxP recognition sites (floxed) in the target gene locus.

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Urinary incontinence and urinary tract infections in octogenarian women. Other modifications at the 3 position of the central pyrazole ring (17b, 23b, 26b-I) enhanced COX-2 inhibitory potency. To introduce and evaluate the outcome of a structured management and counseling protocol for patients with a complaint of a small-sized penis. These findings suggested that low-dose irradiation induced the synthesis of some proteins which were attributed to the enhancement of CFA.

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Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. They differ in expression of some integrins such as VLA2, VLA3 and VLA6, of neuroendocrine-markers such as CD56 and synaptophysin, in the expression of c-kit and in the secretion of certain cytokines and growth factors such as TNFalpha, SDF-1, VEGF, IL-8, GM-CSF and IP-10.

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This study compared the variability of intraocular pressure (IOP) measurements taken with pulse synchronized pneumotonometry (PNT) and with routine PNT (without pulse synchronization) and evaluated the agreement between PNT and Goldmann applanation tonometry (GAT). The results indicated that target identification only profits more from low-frequency than from high-frequency primes if the high-frequency information has a high level of complexity. Visual acuity and clinical conditions were recorded and interviews with respondents were conducted.

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Eighteen species of insects and three spiders were shown to have AFPs. Molecular genetics and control of iron metabolism in hemochromatosis. These findings favour the notion that fever may play an important role in immune responses, and it is possible that fever may act as a physiological adjuvant, with effects on the immune system both in infection and inflammation of other origins. We show that mRNA for TLR1, 2, 4, 5, and 7 are increased after SCI as are molecules associated with TLR signaling (e.g. CAN is the best-known and most frequent complication of dysautonomia.

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Iron overload in thalassemia: comparative analysis of magnetic resonance imaging, serum ferritin and iron content of the liver. The design included two groups of patients admitted before and after the programme. Extent of shape change (ESC) and hypotonic shock response (HSR) have been widely used to characterize the in vitro function of platelets and have been shown to correlate with in vivo viability. Our results indicate that these regions are critical for motor learning and functional plasticity in man. Latex agglutination test: a simple, rapid and practical method for bovine serum CRP determination.

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utilized non-phenolic beta-o-4-model compounds, 2-methoxy-4-formylphenoxyacetic acid and veratrylglycerol-beta-guaiacyl ether (VGE) as sole carbon source. In addition to standard therapy with aspirin, heparin, and primary angioplasty of the right coronary artery, the patient received additional antiplatelet therapy with ticlopidine, hydroxyurea, and the platelet glycoprotein IIb/IIIa receptor-inhibiting monoclonal antibody drug abciximab (ReoPro). To characterize the expression of hsp60 in murine joints, immunoblots of joint extracts and frozen histological sections prepared from normal or arthritic mice were probed with the hsp60-specific MoAb 4B989. Can variations in how different observers deal with this uncertainty be ascertained?

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To test the hypothesis that chronic subdural hematoma (CSDH) enlarges by the causative factors, this study has performed. In the three-spined stickleback, Gasterosteus aculeatus, the plasma concentrations of 11-KT are related to the breeding status of the fish. The Internet has potential as a medium for health behavior change programs, but no controlled studies have yet evaluated the impact of a fully automated physical activity intervention over several months with real-time objective feedback from a monitor.

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Positive CAGE screen correlates with cirrhosis in veterans with chronic hepatitis C. The results of this study suggest that most individuals believe that they would benefit from the use of genetic testing for bipolar disorder if it were to become available. The availability of a framework for the definition of generic objectives for community-based education (CBE) programmes may assist in the rational design of objectives for specific CBE programmes. The hook nail deformity is caused by loss of fingertip bone and soft tissue.

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Immunolocalization of inhibin and activin subunits in human endometrium across the menstrual cycle. We also analysed whether ethanol induces glycoprotein microheterogeneity by altering the sugar composition of dicloran gel bph glycoproteins. Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase. In this double-blind, placebo-controlled clinical trial, we evaluated the effectiveness of a needle-free injection of lidocaine in achieving satisfactory pain control in patients undergoing FNAB of thyroid nodules.

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