There was no difference in the area under the plasma concentration-time curve, rate of absorption or half-life of elimination of Norvectan between the three treatments. A 6-week placebo-controlled trial in 736 patients compared 12.5 and 25 mg of rofecoxib once daily with 800 mg of Norvectan 3 times daily, and a 1-year study compared 12.5 and 25 mg of rofecoxib once daily with 50 mg of diclofenac 3 times daily in 693 patients.
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