Ezetimibe and Prevencor combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Prevencor is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Prevencor/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose) polymerase activity modulates Stat6-dependent gene transcription. Cultures grown at 33 degreesC or 37 degreesC in the absence or presence of transforming growth factor alpha (TGFalpha), keratinocyte growth factor (KGF), basic fibroblast growth factor (bFGF), or insulin-like growth factor (IGF) show a similar morphology to that of native epidermis. During catalysis, electrons are delivered one at a time from the Fe protein to the MoFe protein in a process involving component-protein association and dissociation and hydrolysis of at least two MgATP for each electron transfer. CL can also be produced by the addition of NaO2 or H2O2 to zymosan in a noncellular system.

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The extent of these cancers at the time of the first examination is explained by their clinical latency. The mechanisms that cause carotid atherosclerotic plaque to become symptomatic remain unclear. Inhibition of herpes simplex virus strains isolated from herpetic keratitis by polyinosinic acid-polycytidylic acid. When added to cell suspension of transplantable carcinoma of mouse skin which had been anaplized during a long period of transplantation (over 10 years) this extract inhibits its growth by 39,2 per cent only. It can be concluded that - in view of the diagnostic efficiency of fetopathological investigations - the ultrasonographic diagnosis of hydrocephalus should be interpreted independently from other craniospinal malformations on the basis of principles of ultrasonographic methodology and at different times.

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The procedure is performed transperitoneally with carbon dioxide insufflation to enable video-assisted visualization through a 10-mm endoscope. In the adrenal medulla, the immunoreaction was localized in the supporting cells and the Schwann cells but not in the chromaffin cells. In the one patient who underwent angiography, imaging showed no arterial blood flow to the transplant.

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From May 1987 up to May 2005 a total of 150 patients with primary sclerosing cholangitis but without evidence of cholangiocarcinoma at entry were included in the study. Invertebrate swimming: integrating internal and external mechanics.

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This contrasts with the involvement of STAT3 in the induction of differentiation in somatic cell types. The results show that E2 binds glycosides exclusively in its active-site cleft, with high affinity and specificity. The child underwent surgical resection via a Le Fort I osteotomy approach. In addition to maximizing the chances for an optimal esthetic result, this technique also allows precise adjustment and stability of occlusal relationships for provisionals in the perioperative period.

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This paper describes the synthesis, enzyme substrate/inhibitor properties, and neurotoxic/neuroprotective properties of 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine, the corresponding acyclic secondary amine (E)-4-cyclopropyl-2-phenyl-2-butene, and 4-cyclopropyl-1-methyl-1,2,3,6-tetrahydropyridine. An abundance of experimental evidence compiled over the past two decades now solidly supports the HER2 oncogene hypothesis. Obesity is the most common nutritional disorder in the US and is a major cause of human essential hypertension.

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These increases were significantly suppressed by administration of PFD. Gait was considered to be improved in 20 of 24 patients by the patients or their families.

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Web-based method for translating neurodevelopment from laboratory species to humans. These changes were apparent within 30 min of thyrotropin addition and within 60 min of the addition of dibutyryl cyclic AMP. The cases are reported of three patients with rare tumors of the mammary gland: one osteogenic sarcoma, one benign mixed tumor and one reticulum-cell sarcoma of the breast. We show here that in contrast to observations in mice, infection of macrophage cell cultures with either wild-type (WT) or dam(-) mutant Salmonella resulted in surprisingly similar kinetics and amplitudes of induction of IFN-beta, the type I IFN-alpha,beta beacon gene Mx, and the type II IFN-gamma beacon inducible nitric oxide synthase (iNOS).

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Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo. HPV 16 and 18 play an important role in carcinogenesis of the head and neck, especially, in the oropharynx and larynx. Production of lentiviral vectors by large-scale transient transfection of suspension cultures and affinity chromatography purification.

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The potency of SNC80 and five other piperazinyl benzamides in this assay of schedule-controlled responding correlated with their affinity at cloned human delta opioid receptors but not with their affinity for cloned human mu receptors. Issues at stakes and potential consequences following such changes are discussed. Such a novel structural organization might provide a functional advantage for the efficient biosynthesis of polyketides.

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We have studied the resistance of Toxoplasma gondii-infected mice to subsequent infection with Cryptococcus neoformans. The findings are consistent with reports of striatal enlargement in previously medicated patients and size increases after neuroleptic treatment. This paper presents a novel microfluidic capillary electrophoresis (CE) device featuring a double-T-form injection system and an expansion chamber located at the inlet of the separation channel.

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Modification of the number and structure of certain cytoplasmic components of the renal tubules during compensatory hypertrophy The French health insurance has carried out a survey to estimate the medical and social prevalence for the 30 long-lasting affections.

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Incidence of Dystocia and Perinatal Calf Mortality Resulting from Reciprocal Crossing of Double-muscled and Normal Cattle. Effect of Dai-kenchu-to on gastrointestinal motility based on differences in the site and timing of administration. Our data suggest that HPS may exert a favorable effect on peripheral nerve regeneration. Anaphylactic shock associated with cefuroxime axetil: structure-activity relationships. Mitochondria are subcellular organelles with their own genome which codes for 13 essential protein subunits.

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To report a series of 38 patients presenting retroperitoneoscopic inter-body fusion of the lumbar spine from L2 to L5, performed between 1995 and 1998. The effects of monoclonal aPLs on trophoblast function, including the invasion of JAR into matrigel-coated filters and the effects of annexin V expression on BeWo, were investigated using choriocarcinoma models. Potential mechanisms of the observed irradiation-induced changes in AhR-mediated activities are discussed. Effect of pre-existing lipids on calcinosis of swine heart valve bioprostheses.

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Seven strategies for reduction of delay can be applied, not only at all steps in patient flow and for all demand streams but also at all steps (for example, office visit, diagnostic procedure, surgery, follow-up) and within all specialty care types and ranges of practice. Test day records were classified into 11 periods within first and later lactations. To evaluate three-dimensional optical coherence tomography (OCT) for use in the assessment of the microsurgical anastomoses of vessels and nerves. Western blot showed that islet tissue expressed HO-2, and confocal microscopy revealed that HO-2 resided in insulin, glucagon, somatostatin, and pancreatic polypeptide cells.

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Fluoride release process of (resin-modified) glass-ionomer cements versus (polyacid-modified) composite resins. Here, we confirm that Cys310 of motif VI in Trm4p is essential for nucleophilic catalysis, presumably by forming a covalent link with carbon 6 of cytosine. cause a sight-threatening infection, Acanthamoeba keratitis, mostly in contact-lens wearers.

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This protein act as a peroxidase linked to thioredoxin (Trx)/thioredoxin reductase (TR). Two cases of primary biliary cirrhosis complicated by acute leukemia. Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity.

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Pneumocystis carinii pneumonia developed on day 65 after the allo-BMT. Weekly assessment of worry: an adaptation of the Penn State Worry Questionnaire for monitoring changes during treatment. The antibody reacted with the 1200 kDa fragment and its mother molecule alpha-connectin, but not with beta-connectin.

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Two versions of conformation sensitive gel electrophoresis, fluorescent (F-CSGE) and manual (M-CSGE) techniques, were compared for mutation analysis of the von Willebrand factor gene. Social determinants of ever initiating smoking differ from those of quitting: a cross-sectional study in Estonia.

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The effectiveness of a combination treatment and the underlying molecular determinants of cellular response are unknown. Veterinary accreditation and some new imperatives for national preparedness. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation. beta-actin transcripts were detected in all of the uninfected and infected mice.

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The measurement of the mean lifetime of the positron (tau) in a lithium fluoride (LiF) chip which had been irradiated with up to 40 Gy from a 60Co gamma-ray source demonstrates a correlation between the positron mean lifetime and the dose which has been delivered to the crystal. However, these measurements are equivalent in determining the prevalence of non-responsiveness: FA and MA are affected to the same degree in patients with non-responsiveness. The observed patterns of expression suggest that the extensin genes, cyc15 and cyc17, are under two types of regulation: one that depends on the stage of the cell cycle and another that is induced during the growth arrest. Cloning, expression, and characterization of mouse tissue factor pathway inhibitor (TFPI).

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Rapid eye movement sleep, motoneurone inhibition, and apneic spells in preterm infants. The administration of a cathartic alone has no role in the management of the poisoned patient and is not recommended as a method of gut decontamination. In the present study, transplantation of quail somites into chick hosts showed that the cells in the local environment of the sympathetic trunk are derived from the somite.

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Mode-selecting effects and coherence in hot-plasma x-ray lasers. Moreover, under similar exposure conditions, no adjuvancy was noted in the three Host Resistance models (B16F10 Melanoma, Listeria monocytogenes, and Streptococcus pneumoniae) tested. Roles of the calcineurin and CaMK signaling pathways in fast-to-slow fiber type transformation of cultured adult mouse skeletal muscle fibers. Temporal heterogeneity of regional pulmonary perfusion is spatially clustered.

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Of the four pigs with colon J-pouch, three had signs of impaired pouch evacuation and two had reduced stool frequency. An understanding of the properties of these agents is important for the pharmacist to effectively counsel patients about their use and to serve as a valuable source of information for other health professionals regarding these drugs. The author analyzes the difficulties associated with and errors occurring in x-ray examination. It is not clear if various actions of TGF-beta on normal and tumour cells are due to differential gene regulations.

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Early clinical experience with percutaneous cryosurgical ablation of the prostate. Long-term effects on skeletal growth and articular function in 15 cases treated surgically.

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Although previous studies with clinical samples of Southeast Asian refugees have found gender differences in the degree of psychological distress, the few community-based studies have been inconclusive. This knowledge provides the basis for development of a new generation of vaccines. With a few exceptions, the latter have the highest incidence and severity among the patients with decompensated, with mixed type diabetes and with remote vascular degenerative manifestations.

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Because struma ovarii is composed of thyroid tissue, it is conceivable that the pathogenetic events involved in thyroid follicular transformation may take place also in struma ovarii. The authors evaluated signal changes in the human primary visual cortex during visual stimulation using functional magnetic resonance imaging (MRI) scanner at 1.5 Tesla. Tactile thresholds for detecting a 250-Hz signal of variable duration presented at variable times after the termination of a 250-Hz 700-ms masking stimulus were measured. After getting a colony, successive platings were made using larger and larger vessels, up to 60-mm-diameter petri dishes.

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Induction of macrophage inflammatory protein 2 gene expression by interleukin 1 beta in rat lung. The authors have found this method to be reliable and to reduce the frequency of revisions. Regulation of pituitary receptors for thyrotropin-releasing hormone by thyroid hormones. The benefits of statins on cardiovascular disease in patients who are not experiencing acute coronary syndromes generally become apparent only after about 2 years.

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The implantation of an intraocular lens into the capsular bag is a common procedure in modern cataract surgery. Mechanisms of sustained arterial blood hypertension under experimental ES are considered. The objective of this study was to evaluate the effect of nicotine on postlaparotomy abdominal adhesions.

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Improve consumer satisfaction and recall of healthcare information with social learning theory. Saline wash or centrifugation after harvest produced modest but statistically significant improvements in viability and purity. Long-term tolerance induced by multiple doses of morphine (300 mg/kg/day) differed from that induced by a single dose in persistence (3-4 weeks) rather than in quality or magnitude. Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions.

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Developmental changes in the calcium sensitivity of rabbit cranial arteries. Cerebral infarct secondary to traumatic carotid artery dissection. The objective of the study is to examine whether obese and overweight, compared to normal weight persons, have different experiences of preventive care.

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The detection limit obtained was lower than that of traditional methods including microtitration and agar diffusion. To investigate the effects of low (0.05 micromol/mol) and relatively low (0.10 micromol/mol) concentrations of ozone on photoassimilate partitioning, rice plants grown in a water culture were fed with (13)C-labelled carbon dioxide at the reproductive stage in an assimilation chamber with constant concentration of (12)CO(2) and (13)CO(2). No pathologic respiratory tract lesions were observed in mice administered sulfamerazine starting 1 week before the inoculation.

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The refractive error can be enhanced or diminished depending on the relationship of these axes. Anterior tooth trauma in eleven-year-old South African children.