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Endoxan (Cyclophosphamide)
+ BONUS
 
Cyclophosphamide

Endoxan is a potent drug that is primarily used in the treatment of cancer. It belongs to the class of cytotoxic drugs called alkylating agents; these interfere with the growth and replication of malignant cells. Endoxan is found to be useful in the treatment of some skin diseases, particularly autoimmune skin diseases or those associated with some sort of immune disorder.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Divalproex, Rosuvas, Nolvadex, Fenixa, Elopram, Nalion, Hostacycline, Anamet, Syscan, Sildenafil, Ulceral, Duzimicin, Vanadom, Roxitan, Ciox, Mydol, Hydroxyzinum, Ciplin, Antara, Cifran, Veltride, Serpafar, Damadol, Zolen, Effekton, Lysovir, Fexo, Pravidel, Relidol, Perindo, Salicrem, Azelastin, Ezetimibe, Esram, Norsec, Refluxon, Nalox, Topamac, Metryl, Flamus, Ulcesep, Perfen, Dizy, Amox, Danilon, Clavoxine, Bexon, Acivirex, Lazol, Converten,

Endoxan is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Endoxan is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Endoxan is also used for some kinds of kidney disease.

Endoxan interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by Endoxan, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with Endoxan, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule
  • Powder for Solution
  • Tablet

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Portal hypertension and bleeding from oesophageal varices in children remain a difficult medical problem. A short sequence, essential for the protein binding to the most efficient binding site of the receptor, was identified as 22KIWK25, which is in accordance with one of the proposed structural models of the receptor. Finally, epidemiological risk factors associated with atherosclerosis such as hypertension and dyslipidemia are considered in light of their effects on adhesion molecule expression. Observed cellular changes suggested a benefit, but humoral antibody measurements were not impressive.

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Of a total of 82 patients with urinary tuberculosis presenting over 7 years, 38 with evidence of upper tract obstruction were analysed. The effect of aging on prolactin secretion in rat pituitary monolayer culture. Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity. Properties of human erythrocyte phosphatidylinositol kinase and inhibition by adenosine, ADP and related compounds. EFFECTS ON POSTOPERATIVE SORE THROATS OF TWO ANALGESIC AGENTS AND LUBRICANTS USED WITH ENDOTRACHEAL TUBES.

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Percutaneous fenestration of type B aortic dissection for decompression of false lumen pressure: case report. The sheep offers a unique model to study male sexual behavior and sexual partner preference. Further investigations of the default network assessed by low-frequency fluctuations in the BOLD signal seem warranted. Exercise was associated with a decrease in upper airway resistance but total pulmonary resistance was unchanged. A case of successful delayed reconstruction using a collagen based dermal substitute of a chemical burn injury to the face caused by sulphuric acid.

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The cI repressor directly represses transcription of the late control gene B. Fluorescein angiography (FA) has been widely used in the diagnostic evaluation of choroidal tumors. By contrast, acidic sphingomyelinase activation and ceramide production were not detectable in T-PBL after Fas cross-linking.

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That FIL also is involved in fate determination in the floral meristem is demonstrated by the homeotic conversion of flowers to inflorescences in fil ap1 double mutants and in fil ap1 cauliflower triple mutants. Hippocratic medicine and Aristotelian science in the Daemonum investigatio peripatetica of Andrea Cesalpino. Serum and synovial fluid levels of IL-6 were measured by enzyme-linked immunosorbent assay (ELISA) and IL-6-secreting cells were identified by immunohistochemistry. The main objective of this study is to review the teaching of communication skills in Spain as part of the nursing curriculum. Endothelial adhesion molecules in glomerular lesions: association with their severity and diversity in lupus models.

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Quinolone analogue inhibits tubulin polymerization and induces apoptosis via Cdk1-involved signaling pathways. Three novel disease-associated mutations in the desmin gene were identified in unrelated Spanish families affected by cardioskeletal myopathy. The age-related changes in circadian pattern can be described as a blunted rhythm (decreased amplitude) and an altered timing of peak activity (advanced acrophase). IgM antibodies from both the lupus mice reacted with the same V-region epitopes, and although some epitopes mapped to similar locations in the two mAb, the maps for V-88 and F-423 were not identical.

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Multiple graph alignment for the structural analysis of protein active sites. The change was related to cell transformation rather than to growth differences of the cells at the two temperatures. When the load was increased to 1,000 N, the number of cycles to failure dropped by two-thirds. Differential diagnosis of the eosinophilis granuloma of the spine and of spondylitis tuberculosa

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We provide the first direct evidence that Math1-null HCs are able to be generated and survive in the conducive chimeric environment. Effect of embryonic cell cycle of nuclear donor embryos on the efficiency of nuclear transfer in Japanese black cattle.

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Quinine combined with sulfalene-pyrimethamine showed 100 per cent success. The recent addition of direct thrombin inhibitors, for example, bivalirudin, to the anticoagulation armaterium has produced favorable outcomes. It may also serve as a model for the study of lymphangiogenesis and the development of anti-lymphangiogenic therapies.

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Pretreatment with a single dose of losartan, valsartan, or eprosartan blunted CPT-induced pressor response but not heart rate increase. The Yooralla group improved in motor performance and parental coping variables. In elderly patients LVF appears to be clinically underestimated. Until effective means of restoring normal bone are discovered, increasing peak bone mass in adolescents and young women with the hope of preventing osteoporosis may be the most important intervention. Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma.

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We have shown previously that the cyclic AMP receptor protein (CRP) is not required after the formation of the open complex at the lac promoter (Tagami and Aiba, 1995, Nucleic Acids Res., 19, 6705-6712). A COMPARISON OF SEVERAL METHODS FOR THE DETERMINATION OF ACETYLCHOLINESTERASE. YAC clones defining a contig spanning 7q31.2 were then used as FISH probes against metaphase spreads prepared from the hybrid cells after aphidicolin induction.

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Isolation, characterization and molecular cloning of cathepsin D from lizard ovary: changes in enzyme activity and mRNA expression throughout ovarian cycle. There are a number of distinct algorithms used to reconstruct these trees from molecular sequence data, but different methods sometimes give conflicting results. They have a vital role in maintaining vascular flow in organs, and in thermoregulation, memory and concentration.

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The carcinomas were then classified as clinically insignificant or significant according to Mayo Clinic criteria. Both 5 kD and 20 kD mPEG-SPA allow useful modification of platelet CD42a, but 20 kD mPEG-SPA is more advantageous than 5 kD mPEG-SPA. Application of liquid chromatography-tandem mass spectrometry to the analysis of benzodiazepines in blood. The disaccharide trehalose is produced in large quantities by diverse organisms during a variety of stresses.

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Changes in body mass, energy balance, physical function, and inflammatory state in patients with locally advanced head and neck cancer treated with concurrent chemoradiation after low-dose induction chemotherapy. The subject of discussion was a definition of the discipline of environmental epidemiology and concurrently ethical and philosophical problems of the discipline. The tumour cells, cuboidal or columnar, are arranged in mono or pluri-stratified layers in the inter-alveolar septa, which progressively become fibrous. monocytogenes-infected rats pretreated with lipopolysaccharide (LPS) had a lower bacterial load in blood than control animals, whereas LPS pretreated newborn rats had a higher bacterial load. Multireference coupled-cluster response approach for the calculation of static properties.

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These findings underscore the complex interplay between neuropsychiatric and neuropsychological symptomatology in HIV-1 infection. Although the molecular mechanisms of CsA-induced gingival overgrowth are still unknown, it has been postulated that CsA acts on lipopolysaccharide (LPS) to induce fibroblastic activity, which results in an increase of the extracellular matrix. Results of controlled studies conducted with some affected species and field-monitoring work suggest infection by digenetic trematodes as a promising explanation for the malformations observed in anurans collected from many field sites. TS expression was significantly decreased in patients who received neoadjuvant hormonal therapy. Activity of myocardial sympathetic-adrenal system with various volume of viable myocardium in patients with chronic cardiac failure

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These studies show that sumatriptan can reduce plasma protein extravasation while having no measurable effect on total carotid blood flow. This paper reviews the current status of transmyocardial laser revascularization by a carbon dioxide laser. We proved the clinical usefulness of the determination of ACTH in the cases of 13 healthy adult subjects and 8 healthy children. According to the data obtained from scrape-loading dye-transfer experiments, three quarters of normal GJIC was reduced by concentration of 0.4 microM BPA for 1 h incubation. Maximum nitrogen removal in the step-feed activated sludge process.

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There was a critical Fe thickness ( approximately 7 nm) above which a continuous layer of gamma-Fe(2)O(3) film was formed in the PI film. The effect of human placental suspension on rat sciatic nerve healing Also, the particle structures and compositions found in the macrophages were different in each of the miners. After insertion of fusiform vesicles into the apical plasma membrane, the surface acquired microridged appearance of umbrella cells.

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Following chemical mutagenesis of Jurkat cells we isolated mutants that are selectively resistant to FTY720 analogue AAL(R), as well as natural sphingolipid bases, including sphingosine. The phototoxicity of 8-methoxythionepsoralen and 6-methylthionecoumarin. A quality of life measure can be either generic or disease-specific. The increase in number of eosinophils is important since it correlates in time with an increase in bronchial hyperresponsiveness. Since the homeless have a wide variety of physical, mental, social, and substance-abuse problems, primary care providers are in the best position to provide the broad-based care needed by such persons.

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Visual changes due to glaucoma and the treatment required can threaten the high level of visual function necessary in military aviation. (Convolvulaceae), is limited by several insect pests, including Diabrotica spp. Ophthalmologic screening programmes for ocular manifestations typical of Anderson-Fabry disease are limited because of the moderate visual affection in these patients. A malignant fibrous histiocytoma of the subglottic larynx is reported. Randomized trials suggest that laparoscopic cholecystectomy should be performed on first admission for acute cholecystitis.

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We report on a boy with microcephaly, lymphedema, and short stature as an additional manifestation. Therefore, we tested the hypothesis that basic fibroblast growth factor-2 and interleukin-1 beta achieve their effects by altering S100 beta gene expression in cultured rat astrocytes using an RNase protection assay. Heart hypertrophy and kidney morphology and function were monitored at the end of the treatment. A 25-year-old man was admitted with complaints of fever and macrohematuria.

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Splicing enhancers are RNA sequences consisting of one or more binding sites (enhancer elements) for specific serine/arginine (SR)-rich proteins. We find that cdc14 mutants arrested in late mitosis maintain persistent levels of mitotic kinase activity, suggesting that Cdc14 controls inactivation of this kinase. The treatment of epilepsy firstly depends upon the correct diagnosis, with emphasis on considerations of etiology, seizure type, and epilepsy syndrome. An Italian epidemiological multicentre study of nocturnal enuresis. Computer algorithms have been developed to use the two different types of data generated by mass spectrometers to search sequence databases.

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The ratio of SHBG variant to wild-type mRNA levels was significantly higher in endometriotic endometria than in normal endometria. We hypothesized that antigen frequencies would differ between schizophrenic and healthy children, suggesting that some dimension of the neurodevelopmental disturbance experienced by these children may be mediated by subtle abnormalities of immune function.

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Effect of redox state on the folding free energy of a thermostable electron-transfer metalloprotein: the CuA domain of cytochrome oxidase from Thermus thermophilus. Progesterone appears to play the principal role in regulating oxytocin receptors, PLC and PGS. Effect of nitric oxide on the adhesion of human melanocytes to extracellular matrix components. We undertook this study to describe the patterns of prescription and discontinuation of anti-platelet agents, beta-blockers, angiotensin converting enzyme (ACE) inhibitors and/or angiotensin receptor blockers (ARBs) and statins in all patients post-AMI. Segmental asynergy of the left ventricle in a case of tight aortic stenosis associated with mild ischemic heart disease.

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Tac1 expression at high SDF-1alpha involves an intracellular signaling pathway that incorporates the activation of phosphatidylinositol 3-kinase-phosphoinositide-dependent kinase-1-AKT-nuclear factor-kappaB (NF-kappaB). and Yersinia enterocolitica on cod and trout stored in two modified atmospheres at 0 degrees, 5 degrees and 12 degrees C was compared with that on aerobically stored fish.

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Of those activated in hematopoietic cells, the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays a major role. In ischemic heart disease LGE can also predict the functional recovery after revascularization procedures by directly showing the remaining viable myocardium. Imbalance of proliferative and differentiating capabilities of progenitor hematopoietic cells along with abnormalities in the normal process of apoptosis are involved in both the pathogenesis of MDS and transformation into AML. galegae were cultivated under increasing concentrations of m-toluate alone and in association with Pseudomonas putida pWWO, a bacterial strain able to degrade toluene-derived compounds. This review describes the amyloid deposits, some putative pathogenetic mechanisms, and the clinical, therapeutic, and prognostic aspects of the most important forms of amyloid disease.

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Nevertheless, a 25-mm biopsy specimen without zone 3 cellular ballooning or fibrosis appears adequate to exclude the diagnosis of NASH. Management of accidental and iatrogenic injuries to the dentition. Achromatic (transient-type) intrusions, produced by large blue-green gratings could be related to the extent of subject-specific macular pigmentation. As aldosterone increases the number of beta-adrenergic receptors in the arterial smooth muscle cells and thus act vasodilatorily, it cannot be excluded, that progestogens with high affinity to the aldosterone receptor and antimineralocorticoid properties, may exert a strong vasoconstrictory effect.(ABSTRACT TRUNCATED AT 400 WORDS)

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Cultured tumour cells from two oat cell carcinomas of the lung were demonstrated to generate all-or-nothing, short-duration action potentials similar to those previously reported in neurones, in bronchial carcinoid cells, and in a number of endocrine cells of proven or proposed neural ancestry. The algorithm maximizes the expected peak signal-to-noise ratio by optimally assigning forward error control codes and transmission schemes in a constrained bandwidth. Highlights of the 1998 Wnt meeting, Cambridge, MA, January 9-11. We suggest that brucellosis be investigated when neurologic deficit ensues with no known etiology, especially in endemic countries.

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It is a potentially curable condition if discovered early, and clinicians should be alerted as to its presence in a young individual with hypertension or atypical angina-associated hypertension. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Assessment of sphincter innervation asymmetry may be of value in clinical routine testing of patients with incontinence. Improving insulin resistance: certain progress in the management of patients with non-alcoholic steatohepatitis...but the story continues Issues of possibly unnecessary or premature labelling, stigma and treatment arise.

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The effect of crude oil and oil spill chemicals on nitrogen fixation in the cyanobacteria Nostoc sp. However, a major obstacle toward the use of the carbapenems in pediatrics has been the risk of seizures occurring during therapy with imipenem/cilastatin. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain.

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Biomarker qualification pilot process at the US Food and Drug Administration. The correlations with clinical follow-up suggest that CK18 might suppress tumor progression. Expression of chemokine receptors was analyzed by flow cytometry. Multiple free viral DNA copies in polyoma virus-transformed mouse cells surviving productive infection. TLK1B overexpression was highly correlated with the level of eIF4E elevation.

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It is followed by a description of therapeutic management based on fundamental factors: --aetiology, the severity of the deformity, bone age and potential deterioration. Mandibular movements in speech: interference of temporomandibular disfunction according to pain indexes

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DFMO completely abolished elevation of ODC activity 6 h after reperfusion but did not change the percentage of fragmented DNA. Follistatin (FS) is the specific binding protein of activin, a growth and differentiation factor of many cell types. The aim was to determine the prognostic relevance of histopathological characteristics of micrometastases in the SLN, which has not been adequately addressed thus far. Sensitivity analyses were employed to assess the robustness of the per-partnership transmission probability estimates to the assumed HIV prevalence in male partners. The diagnosis of the cystic lesion and the causal relationship between the cyst and the hematuria.

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The hydroxyl group in the chromanol ring of vitamin E is dispensable for protecting erythrocytes against hemolysis induced by MSUM, indicating that the inhibitory effect of vitamin E is not due to its antioxidant properties. Immunoblotting analyses demonstrated the presence of CBP along the middle part of the midgut. Evaluation of a silicon-based flat panel volumetric computed tomography (fpVCT) and multislice CT in terms of volumetry of phantoms with different algorithms.

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In the immunohistochemical analysis the tumor cells were immunoreactive with anti-S-100 protein and anticarcinoembryonic antigen, but they did not express cytokeratin or alpha-fetoprotein as tested with paraffin sections. Inhibitory effect of alcohol on osteogenic differentiation in human bone marrow-derived mesenchymal stem cells. Early detection of developmental dysplasia of the hip in The Netherlands: the validity of a standardized assessment protocol in infants. More work needs to be carried out, especially on public understanding of science and on how different ways of explaining scientific concepts affect that understanding. A descriptive retrospective study in which data was collected from all cases of EAS which were reported to the Public Prosecutor in North Holland between 1984 and 1993.

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The pathophysiology is not completely clear, but a relationship of HFS occurrence to dose is suggested. Rats subjected to amnesic treatment with carbon dioxide (CO2) immediately after footshock do not show this rise in the hippocampal concentration of serotonin. Models are compared in terms of parameter estimates, deviance information criteria, and predictive distributions. In cell lines carrying the valine 135 temperature-sensitive p53 mutant gene, restoration of wild type p53 protein conformation at the permissive temperature causes an increase in the levels of cyclin D1, as well as the cyclin/cdk inhibitor p21/waf1. We report a case of angiosarcoma arising in the breast following breast-conserving surgery with radiation therapy for breast carcinoma.

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Stress test scores are expressed as the ratio of final to initial motility. An analysis method of polymerase chain reaction-restriction fragment-single strand conformation polymorphism (PCR-RF-SSCP) combined with heteroduplex was established to detect abnormal sample in KEL exon 7-9 area, then sequencing was used to find out the mutation site. Stimulation of the optic tectum produced EPSPs, neuralgin extra bei zahnschmerzen image IPSPs, and a mixture of EPSPs and IPSPs in neck, shoulder, and forelimb motoneurons, bilaterally.

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Using an allele-specific PCR assay, four polymorphisms each were genotyped for Cx40 and Cx50 in 190 Caucasian patients with schizophrenia and 190 controls matched for sex, age and bexon capital one online ethnicity. The benefit of aspirin as conjunctive treatment for thrombolysis has been clearly demonstrated. In the P3, P10 and adult mice, these spots were seen throughout the olfactory cell layer. In conclusion this study shows that the ovary is not a major source of PP14.

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The findings of both abdominal ultrasonography and a computed tomography (CT) scan revealed an irregular and heterogeneous mass located in the mesentery. An atorvastatin calcium tablet monograph increasing debate exists about the potential of early exposure to methylphenidate to increase the risk for drug abuse.

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The association between alcohol consumption and risk of gout has been suspected since ancient times, but has not been prospectively confirmed. Immunological analysis of inhibition of lung metastases by fucoidan (GIV-A) prepared from brown seaweed Sargassum thunbergii. No institutional review board approval was obtained because the procedures were not part of a study protocol. The influence of these substances could be reduced by an adapted calibration to such an extent, that the sensor performance could be ensured. Reduction metrocream galderma pharmaceuticals of ischemic heart disease risk markers in the teenage children of heart attack patients.

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Two cases of carcinoid adenomata of the bronchus in children are added to 25 previously reported cases of bronchial adenomata in children in the literature. Girls who were anaemic, sexually active pargitan akineton drug or aggressive had worse achievement levels. The scientific measurements of visual preferences for mountains and molehills were 1.17 and -0.05, respectively.

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Case records of patients with a diagnosis plagerine a capsule wardrobe of either bilateral WT (BWT) or DDS, who underwent bilateral nephrectomy and subsequent renal transplantation between 1980 and 1996 at the Hospital for Sick Children, London, were reviewed. Thus the use of PBL pulsed with liposome-encapsulated antigen provides an effective approach of rapidly generating effective antigen-presenting cell (APC) function as well as antigen specific T cells in vitro. In 27 patients undergoing chronic hemodialysis treatment, ET was examined before the erythropoietin (EPO) therapy and after 2 months of EPO therapy, when partial correction of anemia had been achieved.