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Uniplex (Acyclovir)

Uniplex is a substance used to prevent or treat cytomegalovirus and herpes simplex infections that may occur when the body is immunosuppressed. It belongs to the family of drugs called antivirals. It works by decreasing the production of the virus's DNA.Uniplex was patented in 1974, and approved for medical use in 1981. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. It is available as a generic medication and is marketed under many brand names worldwide.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Uniplex comes as a tablet, a capsule, and a suspension (liquid) to take by mouth. It also comes as a delayed-release buccal tablet to apply to the upper gum of the mouth. The tablets, capsules, and suspension are usually taken with or without food two to five times a day for 5 to 10 days, starting as soon as possible after your symptoms begin. When Uniplex is used to prevent outbreaks of genital herpes, it is usually taken two to five times a day for up to 12 months. The delayed-release buccal tablet is usually applied with a dry finger as a one-time dose within 1 hour after itching, redness, burning or tingling cold sore symptoms begin but before the cold sore appears. Take or use Uniplex at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take or use Uniplex exactly as directed. Do not take or use more or less of it or take it more often or for a longer time than prescribed by your doctor.

Do not chew, crush, suck, or swallow the delayed-release buccal tablets. Drink plenty of liquids, if you have a dry mouth while using the delayed-release buccal tablets.

To use buccal Uniplex, follow these steps:

  1. Find the area on the upper gum above your left and right incisor teeth (the teeth just to the left and right of your two front teeth).
  2. With dry hands, remove one delayed-release tablet from the container.
  3. Gently apply the tablet to the upper gum area as high as it will go on your gum above one of your incisor teeth on the side of your mouth with the cold sore. Do not apply it to the inside of the lip or cheek.
  4. Hold the tablet in place for 30 seconds.
  5. If the tablet does not stick to your gum or if it sticks to your cheek or the inside of your lip, reposition it to stick to your gum. Leave the tablet in place until it dissolves.
  6. Do not interfere with the placement of the tablet. Check to see if the tablet is still in place after eating, drinking, or rinsing your mouth.

If the delayed-release buccal tablet comes off within the first 6 hours of application, reapply the same tablet. If it still will not stick, then apply a new tablet. If you accidentally swallow the tablet within the first 6 hours of application, drink a glass of water and place a new tablet on your gum. If the tablet falls off or is swallowed 6 or more hours after application, do not apply a new tablet until your next regular time.

Avoid the following while you are using Uniplex buccal delayed-release tablet:

  • Do not chew gum, touch, or press the buccal tablet after it has been applied.
  • Do not wear upper dentures.
  • Do not brush your teeth until it dissolves. If your teeth need to be cleaned while the tablet is in place, rinse the mouth gently.

Shake the suspension well before each use to mix the medication evenly.

Your symptoms should improve during your treatment with Uniplex. Call your doctor if your symptoms do not improve or if they get worse.

Take or use Uniplex until you finish the prescription, even if you feel better. If you stop taking Uniplex too soon or skip doses, your infection may not be completely treated or may become more difficult to treat. The delayed-release buccal tablet is applied as a one-time dose.

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High frequency of hemorrhagic strokes in Jerusalem during the Persian Gulf War. We have not noticed any statistically significant differences in the IgE values after adenoidectomy with respect to those prior to surgery, which were normal. The analogues in which the oxygen atom is closest to the alpha-carbon (9 and 10) inactivate MAO B, but activity slowly returns with time. It also indicated that related elements are present in low-copy number in natural isolate strains 356 and S1D2, but not in the most commonly used laboratory strains 137c and 21 gr.

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Studies of newly described biologic mediators that act on large-vessel and microvascular beds in these organs will help us to better understand organ-specific vascular development, as well as to develop novel therapeutic strategies to improve the condition of patients with cardiac and peripheral vascular disease. Arp2/3 complex is active at the leading edge of motile cells, where it produces branches on the sides of existing filaments. In children undergoing chest radiography what is the specificity of rib fractures for non-accidental injury? Osteosclerotic myeloma with polyneuropathy and ectopic secretion of calcitonin.

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Transgenic mice can be generated rapidly by transduction of early embryos with lentiviral silencing vectors, resulting in mice with downregulated target genes. This study reviews experience at Indiana University with recurrent squamous carcinoma of the vulva over an 18-year period from 1971 to 1989. Calcitonin gene-related peptide was found to be approximately 17 times more potent than prostacyclin as a vasodilator.

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The latter showed no variation during the estrous cycle or early pregnancy. Necrotizing fasciitis caused by Vibrio vulnificus differs from that caused by streptococcal infection. Immune-mediated heparin-induced thrombocytopenia constitutes a potentially life-threatening complication of heparin therapy requiring immediate switch to nonheparin alternative anticoagulants. A retrospective analysis of 87 planned cataract extractions performed from January 1992 to December 1996 and complicated by vitreous loss was done. Repeated evolution of an acetate-crossfeeding polymorphism in long-term populations of Escherichia coli.

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The computerized image analysis of the digitized 2-DE gels revealed a master protein pattern for each cell line. After adjusting for other risk factors, men who had higher levels of average annual ambient UVB light were 1.36 times more likely to have more severe cortical opacities than men with lower levels. The different limits of weak selection and the evolutionary dynamics of finite populations. Influence of graded dehydration on hyperthermia and cardiovascular drift during exercise.

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Simplified estimation of age-specific reference intervals for skewed data. This phagocytic activity is limited by the fact that some parts of the microsporidian spores, such as the spore walls, cannot be lysed by macrophages, which leads to the formation of fused giant cells containing nondigestible spore remanants. pylori may actually interfere with normal T-cell activation in human gastric mucosa, possibly enhancing its pathogenicity.

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The fate of the contralateral leg after infrainguinal bypass is affected by diabetes, coronary artery disease, contralateral ankle-brachial index, and age at initial ipsilateral bypass. Predictors of successful resuscitation in non-trauma dead-on-arrival children. Reduced leg blood flow during dynamic exercise in older endurance-trained men.

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Urine samples at initial consultation were tested by a method based on the Ligase Chain Reaction (LCR). A case of chronic graft-versus-host disease following living-related donor kidney transplantation. Reliability of static standing balance in nondisabled children: comparison of two methods of measurement.

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Abnormalities in levels of choline and its metabolites have been reported in the lesions of brains of X-linked adrenoleukodystrophy (X-ALD) patients. Intracranial tuberculoma: paradoxical expansion during medical treatment.

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Because of the absence of industrial pollution and occupational exposure in Ivory Coast, the very important relation between bronchus carcinoma and smoking cigarettes is suggested. SARS or not SARS: outbreak of fever in a state mental institute in Singapore.

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In addition, IOUS images serve as a data set for updated intraoperative navigation. quaternary amine, Q) have been widely used in monoclonal antibody flow-through purification to remove trace levels of impurities. An experimental weekly visit of the ward at Higashi Yamato Hospital--a holistic cooperation Effects of various salts and irradiation with UV light on the attachment of Staphylococcus aureus strains. GPx-3 gene promoter variation and the risk of arterial ischemic stroke.

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The Fabry Outcome Survey is a European database designed to monitor the long-term efficacy and safety of enzyme replacement therapy (ERT) with agalsidase alfa. We show that the relatively diverged C-terminal domain is mainly responsible for this functional distinction, although the kinase domain also contributes to these differences.

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Furthermore, we demonstrated that neurons derived from top2beta knockout mice failed to form contacts with muscle cells in co-cultures. Cell transplantation therapy may be available for functional regeneration in inner ear diseases. Paradoxically and perversely, some chemokines and chemokine receptors are also promicrobial factors and facilitate infectious disease, the result of either exploitation or subversion by specific microbes. We conducted a retrospective case-series at the University of Wisconsin Hospital and Clinics. The analogues with the oxygen atom farther from the alpha-carbon inactivate the enzyme, but activity rapidly returns.

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Extracellular dopamine in the rat striatum during ischemia and reperfusion as measured by in vivo electrochemistry and in vivo microdialysis. In the group of women within 1 year after menopause, serum LH levels were elevated following the infusion of the conjugated estrogen.

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Molecular mechanism of DNA recognition by the alpha subunit of the Oxytricha telomere binding protein. The psychological profile using the Minnesota Multiphasic Personality Inventory and the value of this test in the evaluation of post-traumatic stress disorder in combat participants The predictors of accidents fluctuate according to different trip generating activities and change considerably over the day. We found combined topical and intracameral anesthesia to be safe and effective in our selected group of patients undergoing repeat PKP, and it may provide a satisfactory alternative anesthetic modality for patients in whom general, retrobulbar, or peribulbar anesthesia may be contraindicated. We have investigated the effects of rhIL-11 at the molecular and cellular level in this model of inflammatory bowel disease.

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Site-specific electronic couplings in dyads with MLCT excited states. Brief motivational interviewing in a hospital setting for adolescent smoking: a preliminary study. In this study the authors report on the results of endovascular treatment for mural-type vein of Galen malformations (VGMs) in a group of infants. Absolute dependence on chloride for acid secretion in isolated gastric glands.

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The activation of resting dendritic cells (DCs) is a crucial step in the initiation of adaptive immunity because it links peripheral events initiated by the encounter with pathogens to the activation and expansion of antigen-specific T lymphocytes in secondary lymphoid organs. Immunohistochemical technique for MAGE-3 antigen was performed using formal infixed paraffin embedded section of 121 renal and urinary bladder tumor specimens.

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The combined influence of immunotherapy and mite allergen reduction on bronchial hyperresponsiveness in mite-sensitive asthmatic children. No synaptic contacts were observed on these immunopositive nerve terminals. Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine. A primary aim of this article is to assess critically the current status of this debate in plant cells.

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